Results 41 to 50 of about 815 (149)

Broad‐range metalloprotease profiling in plants uncovers immunity provided by defence‐related metalloenzyme

New Phytologist, Volume 235, Issue 3, Page 1287-1301, August 2022., 2022
Summary Plants encode > 100 metalloproteases representing > 19 different protein families. Tools to study this large and diverse class of proteases have not yet been introduced into plant research. We describe the use of hydroxamate‐based photoaffinity probes to explore plant proteomes for metalloproteases.
Kyoko Morimoto, Daniel Krahn, Farnusch Kaschani, Digby Hopkinson‐Woolley, Anna Gee, Pierre Buscaill, Shabaz Mohammed, Stephan A. Sieber, Benjamin F. Cravatt, Christopher J. Schofield, Renier A. L. van der Hoorn   +10 more
wiley   +1 more source

Lysosomes and lysosome‐related organelles in immune responses

FEBS Open Bio, Volume 12, Issue 4, Page 678-693, April 2022., 2022
Lysosomes provide an environment that supports key events in the immune response including the processing of antigens for presentation on MHC molecules and the activation of some toll‐like receptors. Some leukocytes develop lysosome‐related organelles (LROs) to achieve their mostly cytotoxic effector functions.
Colin Watts
wiley   +1 more source

Sub‐cellular localization of insulin‐regulated membrane aminopeptidase, IRAP to vesicles in neurons [PDF]

Journal of Neurochemistry, 2007
AbstractAngiotensin IV and LVV‐hemorphin 7 promote robust enhancing effects on learning and memory. These peptides are also competitive inhibitors of the insulin‐regulated membrane aminopeptidase, suggesting that the biological actions of these peptides may result from inhibition of IRAP activity.
Fernando, Ruani N, Luff, Susan E, Albiston, Anthony L, Chai, Siew Yeen   +3 more
openaire   +3 more sources

The interacting physiology of COVID‐19 and the renin‐angiotensin‐aldosterone system: Key agents for treatment

Pharmacology Research &Perspectives, Volume 10, Issue 1, February 2022., 2022
When SARS‐CoV‐2 enters cells by binding to ACE2; it stimulates local Ang II production. This recruits innate defence mechanisms. It also destroys ACE2 and so leaves Ang II‐AT1R induced inflammation unchecked. Abstract SARS‐CoV‐2 interacting with its receptor, angiotensin‐converting enzyme 2 (ACE2), turns the host response to viral infection into a ...
Eugenie R. Lumbers, Richard Head, Gary R. Smith, Sarah J. Delforce, Bevyn Jarrott, Jennifer H. Martin, Kirsty G. Pringle   +6 more
wiley   +1 more source

[Retracted] Beta‐Sitosterol Facilitates GLUT4 Vesicle Fusion on the Plasma Membrane via the Activation of Rab/IRAP/Munc 18 Signaling Pathways in Diabetic Gastrocnemius Muscle of Adult Male Rats

Bioinorganic Chemistry and Applications, Volume 2022, Issue 1, 2022., 2022
Nutritional overload in the form of high‐fat and nonglycolysis sugar intake contributes towards the accelerated creation of reactive oxygen species (ROS), hyperglycemia, and dyslipidemia. Glucose absorption and its subsequent oxidation processes in fat and muscle tissues alter as a consequence of these modifications.
JinJin Pei, Monisha Prasad, Ghada Mohamed Helal, Mohamed El-Sherbiny, Dalia Mahmoud Abdelmonem Elsherbini, Ponnulakshmi Rajagopal, Chella Perumal Palanisamy, Vishnu Priya Veeraraghavan, Selvaraj Jayaraman, Krishna Mohan Surapaneni, Senthil Rethinam   +10 more
wiley   +1 more source

Distinct antigen uptake receptors route to the same storage compartments for cross‐presentation in dendritic cells

Immunology, Volume 164, Issue 3, Page 494-506, November 2021., 2021
Antigens taken up by dendritic cells via Fcγ receptors or C‐type lectin receptor MGL1 are routed towards the same endolysosomal compartments, which express LAMP1 and active cathepsin X. These compartments can conserve antigen for several days and serve as an antigen depot for prolonged antigen cross‐presentation to CD8+ T cells.
Nataschja I. Ho, Marcel G. Camps, Juan J. Garcia‐Vallejo, Erik Bos, Abraham J. Koster, Martijn Verdoes, Yvette van Kooyk, Ferry Ossendorp   +7 more
wiley   +1 more source

The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation

Frontiers in Immunology, 2022
The Endoplasmic Reticulum Aminopeptidase 1 and 2 (ERAP1 and ERAP2) and Insulin Regulated Aminopeptidase (IRAP) are three M1 zinc metalloproteases whose role in antigen processing is the refining of peptidome either in the Endoplasmic reticulum (ERAP1 and
Benedetta Mattorre, Valentina Tedeschi, Giorgia Paldino, Maria Teresa Fiorillo, Fabiana Paladini, Rosa Sorrentino   +5 more
doaj   +1 more source

Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures

Current Issues in Molecular Biology, 2022
Angiotensin IV (Ang IV), a metabolite of Angiotensin II, is a bioactive hexapeptide that inhibits the insulin-regulated aminopeptidase (IRAP). This transmembrane zinc metallopeptidase with many biological functions has in recent years emerged as a new ...
Frida Stam, Sara Florén Lind, Anja Schroff, Sofia Zelleroth, Erik Nylander, Johan Gising, Alfhild Grönbladh, Mats Larhed, Mathias Hallberg   +8 more
doaj   +1 more source

Angiotensin AT₄ ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP) [PDF]

Journal of Neurochemistry, 2003
AbstractAngiotensin IV (Ang IV) exerts profound effects on memory and learning, a phenomenon ascribed to its binding to a specific AT4 receptor. However the AT4 receptor has recently been identified as the insulin‐regulated aminopeptidase (IRAP). In this study, we demonstrate that AT4 receptor ligands, including Ang IV, Nle1‐Ang IV, divalinal‐Ang IV ...
Rebecca A, Lew, Tomris, Mustafa, Siying, Ye, Sharon G, McDowall, Siew Yeen, Chai, Anthony L, Albiston   +5 more
openaire   +2 more sources

IRAP Endosomes Control Phagosomal Maturation in Dendritic Cells

Frontiers in Cell and Developmental Biology, 2020
Dendritic cells (DCs) contribute to the immune surveillance by sampling their environment through phagocytosis and endocytosis. We have previously reported that, rapidly following uptake of extracellular antigen into phagosomes or endosomes in DCs, a ...
Mirjana Weimershaus, François-Xavier Mauvais, Irini Evnouchidou, Irini Evnouchidou, Myriam Lawand, Loredana Saveanu, Peter van Endert   +6 more
doaj   +1 more source