AKT and AMP-activated protein kinase regulate TBC1D1 through phosphorylation and its interaction with the cytosolic tail of insulin-regulated aminopeptidase IRAP. [PDF]
J Biol Chem, 2018 In skeletal muscle, the Rab GTPase-activating (GAP) protein TBC1D1 is phosphorylated by AKT and AMP-activated protein kinase (AMPK) in response to insulin and muscle contraction. Genetic ablation of Tbc1d1 or mutation of distinct phosphorylation sites impairs intracellular GLUT4 retention and GLUT4 traffic, presumably through alterations of the ...
Mafakheri S +10 more
europepmc +4 more sources
Frontiers in Molecular Biosciences, 2020 Placental leucine aminopeptidase/insulin-regulated aminopeptidase (P-LAP/IRAP) regulates vasopressin and oxytocin levels in the brain and peripheral tissues by controlled degradation of these peptides.
Yoshikuni Goto +4 more
doaj +3 more sources
Development of a sandwich ELISA to detect circulating, soluble IRAP as a potential disease biomarker [PDF]
Scientific Reports, 2023 There is growing interest in the use of the enzyme, insulin regulated aminopeptidase (IRAP), as a biomarker for conditions such as cardio-metabolic diseases and ischemic stroke, with upregulation in its tissue expression in these conditions.
Anika Vear +5 more
doaj +2 more sources
Inhibition of insulin-regulated aminopeptidase confers neuroprotection in a conscious model of ischemic stroke [PDF]
Scientific Reports, 2023 Stroke is a leading cause of mortality and morbidity with a paucity of effective pharmacological treatments. We have previously identified insulin-regulated aminopeptidase (IRAP) as a potential target for the development of a new class of drugs for the ...
Jonathon Telianidis +6 more
doaj +2 more sources
From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase
Frontiers in Pharmacology, 2020 It was reported three decades ago that intracerebroventricular injection of angiotensin IV (Ang IV, Val-Tyr-Ile-His-Pro-Phe) improved memory and learning in the rat. There are several explanations for these positive effects of the hexapeptide and related
Mathias Hallberg, Mats Larhed
doaj +2 more sources
Role of the Insulin-Regulated Aminopeptidase IRAP in Insulin Action and Diabetes
Biological and Pharmaceutical Bulletin, 2004 The insulin-regulated aminopeptidase (IRAP) is a member of the family of zinc-dependent membrane aminopeptidases. It is the homolog of the human placental leucine aminopeptidase (P-LAP). IRAP is expressed in different cell types but has been best characterized in two major insulin target cells, muscle and fat.
exaly +4 more sources
Angiotensin IV Receptors in the Rat Prefrontal Cortex: Neuronal Expression and NMDA Inhibition [PDF]
BiomedicinesBackground: N-methyl-D-aspartate type glutamate receptors (NMDARs) are fundamental to neuronal physiology and pathophysiology. The prefrontal cortex (PFC), a key region for cognitive function, is heavily implicated in neuropsychiatric disorders ...
Zsolt Tamás Papp +11 more
doaj +2 more sources
Sexual and Metabolic Differences in Hippocampal Evolution: Alzheimer’s Disease Implications [PDF]
LifeSex differences in brain metabolism and their relationship to neurodegenerative diseases like Alzheimer’s are an important emerging topic in neuroscience.
José Manuel Martínez-Martos +5 more
doaj +2 more sources
Intrathecal injections of non-peptide oxytocin receptor agonists, WAY 267,464 and TC OT 39, induce significant anti-hyperalgesia in both male and female rats with inflammatory pain [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Hyperalgesia is a clinical condition related to chronic pain in which patients experience increased nociceptive sensitivity. Intrathecal oxytocin has been shown to induce significant anti-hyperalgesia in both rodents and humans. However, in
Lok-Hi Chow +4 more
doaj +2 more sources
, 2020 Insulin-regulated aminopeptidase (IRAP) has emerged as a potential new therapeutic target for treatment of cognitive disorders. Inhibition of the enzymatic activity facilitates cognition in rodents. Potent and selective peptide and pseudopeptide based inhibitors have been developed, but most of them suffer from poor pharmacokinetics and blood-brain ...
Engen, Karin
openaire +2 more sources