Results 11 to 20 of about 815 (149)

IRAP Drives Ribosomal Degradation to Refuel Energy for Platelet Activation during Septic Thrombosis [PDF]

Advanced Science
Platelets play crucial roles in multiple pathophysiological processes after energy‐dependent activation. It is puzzling how such a small cellular debris has abundant energy supply.
Baichuan Xu, Xianpeng Ye, Kangfu Sun, Liang Chen, Zhaoyang Wen, Qigang Lan, Jun Chen, Mo Chen, Mingqiang Shen, Song Wang, Yang Xu, Xi Zhang, Jinghong Zhao, Junping Wang, Shilei Chen   +14 more
doaj   +3 more sources

Decreased Levels of Insulin-Regulated Aminopeptidase (IRAP) in Gestational Diabetes Mellitus: A Prospective Cohort Study

Clinical and Experimental Obstetrics & Gynecology
Background: Insulin-regulated aminopeptidase (IRAP) is involved in insulin sensitivity and glucose metabolism and is important in the pathophysiology of type 2 diabetes.
Osman Köse, Koray Gök, Elif Köse, Sezen Irmak Gözükara, Abdullah Tüten, Mehmet Sühha Bostancı   +5 more
doaj   +3 more sources

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro‐Oxindole Dihydroquinazolinones as IRAP Inhibitors

ChemistryOpen, 2020
Insulin‐regulated aminopeptidase (IRAP) is a new potential macromolecular target for drugs aimed for treatment of cognitive disorders. Inhibition of IRAP by angiotensin IV (Ang IV) improves the memory and learning in rats.
Karin Engen, Dr. Sudarsana Reddy Vanga, Dr. Thomas Lundbäck, Dr. Faith Agalo, Vivek Konda, Dr. Annika Jenmalm Jensen, Prof. Johan Åqvist, Dr. Hugo Gutiérrez‐de‐Terán, Prof. Dr. Mathias Hallberg, Prof. Dr. Mats Larhed, Dr. Ulrika Rosenström   +10 more
doaj   +3 more sources

Binding of “AT4 receptor” ligands to insulin regulated aminopeptidase (IRAP) in intact Chinese hamster ovary cells [PDF]

Molecular and Cellular Endocrinology, 2011
Insulin regulated aminopeptidase (IRAP) recognises "AT(4)-receptor" ligands like angiotensin IV (Ang IV) and peptidomimetics like AL-11. The metabolic stability and high affinity of [(3)H]AL-11 for catalytically active IRAP allowed its detection in Chinese hamster ovary (CHO-K1) cell membranes in the absence of chelators (Demaegdt et al., 2009).
Heidi Demaegdt, Paul Gard, Aneta Lukaszuk   +2 more
exaly   +6 more sources

Enhanced recombinant expression and purification of human IRAP for biochemical and crystallography studies

Biochemistry and Biophysics Reports, 2021
Insulin-regulated aminopeptidase (IRAP) in humans is a membrane bound enzyme that has multiple functions. It was first described as a companion protein of the insulin-responsive glucose transporter, Glut4, in specialized vesicles.
Lufei Sui, Hwai-Chen Guo
doaj   +2 more sources

Novel macrocyclic peptidomimetics targeting the insulin-regulated aminopeptidase (IRAP): design, synthesis and evaluation. [PDF]

RSC Med Chem
A new synthetic platform enables late-stage macrocycle diversification, revealing how subtle C-terminal changes affect potency and guide IRAP inhibitor design.
Olaniran Håkansson E, Balestri LJI, Puthiyaparambath S, Moes S, Henschel H, Sköld C, Hallberg M, Larhed M, Skillinghaug B, Odell LR.   +9 more
europepmc   +4 more sources

A PCR-RFLP method for detection of the LNPEP encoding human insulin-regulated aminopeptidase (IRAP) rs4869317 polymorphism. [PDF]

Indian J Med Res, 2016
Background & objectives: Insulin regulated aminopeptidase (IRAP) has been related to certain pathologies such as breast cancer, Alzheimer's disease and septic shock. IRAP is encoded by the leucyl/cystinyl aminopeptidase (LNPEP) gene.
RamIrez-Expósito MJ, MartInez-Martos JM, Palomeque T, Lorite P.   +3 more
europepmc   +3 more sources

IRAP Inhibitors: M1-Aminopeptidase Family Inspiration

Frontiers in Pharmacology, 2020
The insulin regulated aminopeptidase (IRAP) has been proposed as an important therapeutic target for indications including Alzheimer’s disease and immune disorders.
Nicholas Barlow, Philip E. Thompson
doaj   +3 more sources

Lipid-induced S-palmitoylation of Insulin-Responsive Aminopeptidase (IRAP) drives the onset of insulin resistance in the heart [PDF]

Cellular and Molecular Life Sciences
Excessive accumulation of long-chain fatty acids (LCFAs) in cardiomyocytes leads to cardiac lipid-induced insulin resistance (CLIR), impairing insulin signaling and glucose uptake.
Francesco Schianchi, Jeroen Guns, Freek G. Bouwman, Jeroen F.J. Bogie, Miranda Nabben, Agnieszka Strzelecka, Rick van Leeuwen, Dimitris Kapsokalyvas, Kaitlyn M.J.H. Dennis, Lisa C. Heather, Shujin Wang, Jan F.C. Glatz, Dietbert Neumann, Joost J.F.P. Luiken   +13 more
doaj   +2 more sources

The effects of insulin-regulated aminopeptidase inhibition with HA08 on recognition memory acquisition and spatial working memory under reversed circadian conditions in male rats [PDF]

IBRO Neuroscience Reports
In 1995, a new M1 aminopeptidase member was discovered in fat and muscle cells, the insulin regulated aminopeptidase (IRAP; oxytocinase; placental leucine aminopeptidase).
Frida Stam, Sara Bjurling, Sofia Zelleroth, Sally Badrd'din, Johan Gising, Mats Larhed, Mathias Hallberg, Alfhild Grönbladh   +7 more
doaj   +2 more sources