Results 51 to 60 of about 815 (149)

Is There an Interplay Between the Functional Domains of IRAP?

Frontiers in Cell and Developmental Biology, 2020
As a member of the M1 family of aminopeptidases, insulin regulated aminopeptidase (IRAP) is characterized by distinct binding motifs at the active site in the C-terminal domain that mediate the catalysis of peptide substrates.
Anika Vear, Tracey Gaspari, Philip Thompson, Siew Yeen Chai   +3 more
doaj   +1 more source

Serum IRAP, a Novel Direct Biomarker of Prediabetes and Type 2 Diabetes?

Frontiers in Molecular Biosciences, 2021
Insulin resistance (IR), currently called prediabetes (PD), affects more than half of the adult population worldwide. Type 2 diabetes (T2D), which often follows in the absence of treatment, affects more than 475 million people and represents 10–20% of ...
Candice Trocmé, Nicolas Gonnet, Margaux Di Tommaso, Hanen Samouda, Jean-Luc Cracowski, Jean-Luc Cracowski, Jean-Luc Cracowski, Claire Cracowski, Stéphanie Lambert-Porcheron, Stéphanie Lambert-Porcheron, Martine Laville, Martine Laville, Martine Laville, Estelle Nobécourt, Chiraz Gaddhab, Allan Le Lay, Torsten Bohn, Christine Poitou, Christine Poitou, Karine Clément, Karine Clément, Fahd Al-Mulla, Milad S. Bitar, Milad S. Bitar, Serge P. Bottari, Serge P. Bottari, Serge P. Bottari, Serge P. Bottari   +27 more
doaj   +1 more source

Nonclassical Axis of the Renin‐Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR‐Alpha Activation during Myocardial Ischemia in a Metabolic Syndrome Model

PPAR Research, Volume 2020, Issue 1, 2020., 2020
The activation of the renin‐angiotensin system (RAS) participates in the development of metabolic syndrome (MetS) and in heart failure. PPAR‐alpha activation by fenofibrate reverts some of the effects caused by these pathologies. Recently, nonclassical RAS components have been implicated in the pathogenesis of hypertension and myocardial dysfunction ...
María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo del Valle-Mondragón, Elizabeth Soria-Castro, Juan Carlos Torres-Narváez, Elizabeth Carreón-Torres, Alicia Sánchez-Mendoza, María Esther Rubio-Ruíz, Sainan Li   +8 more
wiley   +1 more source

Sex Difference in Oxytocin-Induced Anti-Hyperalgesia at the Spinal Level in Rats with Intraplantar Carrageenan-Induced Inflammation. [PDF]

PLoS ONE, 2016
Previously, we demonstrated intrathecal administration of oxytocin strongly induced anti-hyperalgesia in male rats. By using an oxytocin-receptor antagonist (atosiban), the descending oxytocinergic pathway was found to regulate inflammatory hyperalgesia ...
Lok-Hi Chow, Yuan-Hao Chen, Wan-Chuan Wu, En-Pei Chang, Eagle Yi-Kung Huang   +4 more
doaj   +1 more source

Local renin angiotensin system and sperm DNA fragmentation

Asian Journal of Andrology, 2022
The renin angiotensin system (RAS) appears to influence male fertility at multiple levels. In this work, we analyzed the relationship between the RAS and DNA integrity.
María Victoria Aparicio Prieto, María Victoria Rodríguez Gallego, Asier Valdivia Palacín, Yosu Franco Iriarte, Gotzone Hervás Barbara, Enrique Echevarría Orella, Luis Casis Saenz   +6 more
doaj   +1 more source

Anti-Inflammatory and Antitumor Effects of Hydroxytyrosol but Not Oleuropein on Experimental Glioma In Vivo. A Putative Role for the Renin-Angiotensin System

Biomedicines, 2018
Functional roles of the angiotensin peptides of the renin-angiotensin system (RAS) cascade can be analyzed through their corresponding proteolytic regulatory enzymes aspartyl aminopeptidase (ASAP), aminopeptidase A (APA), aminopeptidase B (APB ...
María Jesús Ramírez-Expósito, José Manuel Martínez-Martos   +1 more
doaj   +1 more source

Inhibition of Insulin-Regulated Aminopeptidase: A Novel Therapeutic Strategy for Stroke

, 2022
This thesis characterises and validates a preclinical model of stroke that closely mimics human stroke. In this preclinical model, novel drug therapies that target the insulin-regulated aminopeptidase (IRAP), an enzyme found in the brain, were tested ...
JONATHON TELIANIDIS (14071242)
core   +1 more source

Affinity between TBC1D4 (AS160) phosphotyrosine-binding domain and insulin-regulated aminopeptidase cytoplasmic domain measured by isothermal titration calorimetry [PDF]

BMB Reports, 2012
Uptake of circulating glucose into the cells happens via the insulin-mediated signalling pathway, which translocates the glucosetransporter 4 (GLUT4) vesicles from the intracellular compartmentto the plasma membrane.
SangYoun Park*, Keon Young Kim, Sunmin Kim & Young Seok Yu
doaj  

The effect of insulin resistance on amygdale glucose metabolism alterations in experimental Alzheimer’s disease

Бюллетень сибирской медицины, 2018
Purpose. Glucose metabolism is tightly regulated in the brain. Aberrant glucose metabolism is an important feature of neurodegenerative diseases, as inAlzheimer’s disease.
Ya. V. Gorina, Yu. K. Komleva, O. L. Lopatina, A. I. Chernykh, A. B. Salmina   +4 more
doaj   +1 more source

Mechanisms underlying the physiological and pathological roles of IRAP

, 2023
Insulin regulated aminopeptidase (IRAP) is a multifunctional enzyme which has many different roles in maintaining normal physiology and in disease states. For example, our laboratory has identified IRAP as a new target for the treatment of organ fibrosis.
ANIKA ELSE VEAR (14711626)
core   +1 more source