Results 161 to 170 of about 94,888 (208)

Rare Conditions of Hyperandrogenism Through Lifespan: A Case Series. [PDF]

Case Rep Endocrinol
Apostolopoulou M, Taayedi R, Sărac CP, Demtröder F.   +3 more
europepmc   +1 more source

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Magnetically labeled insulin-secreting cells

Biochemical and Biophysical Research Communications, 2004
Iron oxide nanoparticles have been shown to magnetically label cells in order to visualize them in vivo via MR imaging. This technology has yet to be implemented in insulin secreting cells, thus it is not known whether the presence of these nanoparticles in the cytoplasm of the cells affects insulin secretion.
Jose, Oca-Cossio, Hui, Mao, Nata, Khokhlova, Christopher McE, Kennedy, Jonathan W, Kennedy, Cheryl L, Stabler, Encai, Hao, Athanassios, Sambanis, Nicholas E, Simpson, Ioannis, Constantinidis   +9 more
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Congenital absence of insulin‐secreting cells

Histopathology, 1988
A male infant was diagnosed as having diabetes mellitus 1d after birth and died on the third day. Histological examination of the pancreas showed small and inconspicuous islets of Langerhans that were completely devoid of insulin‐secreting cells. There was no evidence of insulitis.
K C, Wong, K, Tse, J K, Chan
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Purinergic receptors on insulin‐secreting cells

Fundamental & Clinical Pharmacology, 1994
Summary—The insulin secreting B cell is fitted with the two types of purinergic receptors: P2(for ATP and/or ADP) and P1(for adenosine). The activation of P2purinoceptors by ATP or ADP evokes a biphasic stimulation of insulin secretion from isolated perfused rat pancreas; this stimulation is dose‐dependent between 10−6and 10−4M.
D, Hillaire-Buys, J, Chapal, G, Bertrand, P, Petit, M M, Loubatières-Mariani   +4 more
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Increased Insulin Secretion from Insulin-Secreting Cells by Construction of Mixed Multicellular Spheroids

Pharmaceutical Research, 2015
We previously have shown that multicellular spheroids containing insulin-secreting cells are an effective therapy for diabetic mice. Here we attempted to increase insulin secretion by incorporating other cell types into spheroids.Multicellular spheroids of mouse MIN6 pancreatic β cells were formed in microwells alone and with aortic vascular ...
Kosuke, Kusamori, Makiya, Nishikawa, Narumi, Mizuno, Tomoko, Nishikawa, Akira, Masuzawa, Yutaro, Tanaka, Yuya, Mizukami, Kazunori, Shimizu, Satoshi, Konishi, Yuki, Takahashi, Yoshinobu, Takakura   +10 more
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Desensitization of the insulin‐secreting beta cell

Journal of Cellular Biochemistry, 1992
AbstractIn human diabetes, inherent impaired insulin secretion can be exacerbated by desensitization of the β cell by chronic hyperglycemia. Interest in this phenomenon has generated extensive studies in genetic or experimentally induced diabetes in animals and in fully in vitro systems, with often conflicting results.
G M, Grodsky, J L, Bolaffi
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Calmodulin in various insulin secreting cell types

Journal of Endocrinological Investigation, 1985
The involvement of the Ca2+ binding protein, calmodulin, in the regulation of insulin release was studied. Calmodulin was measured in isolated rat islets, rat insulinoma cells, the insulin secreting cell line (RINm5F) and in islets isolated from normal and diabetic Chinese hamsters. Total content of calmodulin was determined by a radioimmunoassay using
D, Janjic, C B, Wollheim, A E, Renold
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Insulin secretion from isolated pure beta cells

Biochemical and Biophysical Research Communications, 1985
Isolation of pure beta cells of the rat pancreas was achieved employing counterflow sedimentation technique (CST) followed by density gradient centrifugation technique (DGCT). The proportion of non-endocrine cells to beta cells was minimal (1 acinar cell in 296 beta cells, and 1 duct cell in 300 beta cells) with total absence of alpha and delta cells ...
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β-Cell Lipases and Insulin Secretion

Diabetes, 2006
Lipids have been implicated in β-cell stimulus-secretion coupling. Thus, lipases in β-cells would be required to generate coupling factors from intracellular lipids. Indeed, we found that glucose stimulates lipolysis in rodent islets and clonal β-cells.
Malin Fex, Stephanie Lucas, Maria Sörhede Winzell, Bo Ahrén, Cecilia Holm, Hindrik Mulder   +5 more
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Hexose Recognition by Insulin-Secreting BRIN-BD11 Cells

Biochemical and Biophysical Research Communications, 1996
Clonal BRIN-BD11 cells were produced by electrofusion of NEDH rat islet B-cells with immortal RINm5F cells. Western blotting analysis revealed that unlike RINm5F, novel BRIN-BD11 cells expressed high levels of the glucose transport protein GLUT-2, coupled with a rapid and sustained uptake of D-glucose, significantly greater than RINm5F after only 5 min
N H, McClenaghan, A M, Gray, C R, Barnett, P R, Flatt   +3 more
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