Results 271 to 280 of about 131,691 (303)

Purinergic receptors on insulin‐secreting cells

Fundamental & Clinical Pharmacology, 1994
Summary—The insulin secreting B cell is fitted with the two types of purinergic receptors: P2(for ATP and/or ADP) and P1(for adenosine). The activation of P2purinoceptors by ATP or ADP evokes a biphasic stimulation of insulin secretion from isolated perfused rat pancreas; this stimulation is dose‐dependent between 10−6and 10−4M.
D, Hillaire-Buys, J, Chapal, G, Bertrand, P, Petit, M M, Loubatières-Mariani   +4 more
openaire   +2 more sources

Increased Insulin Secretion from Insulin-Secreting Cells by Construction of Mixed Multicellular Spheroids

Pharmaceutical Research, 2015
We previously have shown that multicellular spheroids containing insulin-secreting cells are an effective therapy for diabetic mice. Here we attempted to increase insulin secretion by incorporating other cell types into spheroids.Multicellular spheroids of mouse MIN6 pancreatic β cells were formed in microwells alone and with aortic vascular ...
Kosuke, Kusamori, Makiya, Nishikawa, Narumi, Mizuno, Tomoko, Nishikawa, Akira, Masuzawa, Yutaro, Tanaka, Yuya, Mizukami, Kazunori, Shimizu, Satoshi, Konishi, Yuki, Takahashi, Yoshinobu, Takakura   +10 more
openaire   +2 more sources

Insulin Secreting Islet Cell Tumors of the Pancreas

Archives of Surgery, 1966
FUNCTIONING islet tumors of the pancreas producing spontaneous hypoglycemia have been studied with interest at McGill University since the original report from the Pathological Institute by Nicholls 1 in 1902. In 1927, Wilder et al 2 demonstrated the relationship between hyperinsulinism and a malignant islet cell tumor by means of bioassay of the ...
J J, White, V A, Piccone, D R, Webster, J R, McCorriston   +3 more
openaire   +2 more sources

Potassium channels of the insulin‐secreting B cell

Fundamental & Clinical Pharmacology, 1992
Summary—Ionic and electrical events play a central role in the stimulus‐secretion coupling of the pancreatic B cell. Potassium permeability is critically involved in the regulation of B cell membrane potential and insulin secretion. In the absence of glucose, membrane potential remains stable, around − 65 mV. This resting potential is mainly determined
P, Petit, M M, Loubatières-Mariani
openaire   +2 more sources

Calmodulin in various insulin secreting cell types

Journal of Endocrinological Investigation, 1985
The involvement of the Ca2+ binding protein, calmodulin, in the regulation of insulin release was studied. Calmodulin was measured in isolated rat islets, rat insulinoma cells, the insulin secreting cell line (RINm5F) and in islets isolated from normal and diabetic Chinese hamsters. Total content of calmodulin was determined by a radioimmunoassay using
D, Janjic, C B, Wollheim, A E, Renold
openaire   +2 more sources

On-Line Monitoring of Apoptosis in Insulin-Secreting Cells

Diabetes, 2003
Apoptosis was monitored in intact insulin-producing cells both with microfluorometry and with two-photon laser scanning microscopy (TPLSM), using a fluorescent protein based on fluorescence resonance energy transfer (FRET). TPLSM offers three-dimensional spatial information that can be obtained relatively deep in tissues.
Martin, Köhler, Sergei V, Zaitsev, Irina I, Zaitseva, Barbara, Leibiger, Ingo B, Leibiger, Mikael, Turunen, Iouri L, Kapelioukh, Linda, Bakkman, Ioulia B, Appelskog, Jacques Boutet, de Monvel, Gabriela, Imreh, Per-Olof, Berggren   +11 more
openaire   +2 more sources

Insulin‐Secreting Islet‐Cell Tumours of the Pancreas

Australian and New Zealand Journal of Surgery, 1967
Some current thoughts on the subject of insulin‐secreting islet‐cell tumours of the pancreas are presented, and a typical case is reported. On the diagnostic side, mention is made of newer aids to diagnosis in the form of tolbutamide and leucine tests and possibly insulin assays.
openaire   +2 more sources

Some aspects of the morphology of insulin-secreting cells

Acta Histochemica, 1976
By using a spectrum of microscopical techniques such as thin sectioning, autoradiography, cytochemistry and freeze-etching, it is possible to unravel the main cytological events associated with synthesis, intracellular transport, storage and discharge of the hormone insulin by B-cell of the islet of Langerhans.
openaire   +2 more sources

Inhibition of K-Channels in Insulin Secreting Cells

1986
The major physiological stimulus for insulin secretion from pancreatic β-cells is an elevation of the plasma glucose concentration. The initial effect is to evoke membrane depolarization4 followed by a cyclical pattern of electrical activity consisting of slow waves of depolarization with action potential-like spikes.9,12 Tracer flux studies have ...
O H, Petersen, I, Findlay, M J, Dunne
openaire   +2 more sources

β-Cell Lipases and Insulin Secretion

Diabetes, 2006
Lipids have been implicated in β-cell stimulus-secretion coupling. Thus, lipases in β-cells would be required to generate coupling factors from intracellular lipids. Indeed, we found that glucose stimulates lipolysis in rodent islets and clonal β-cells.
Malin Fex, Stephanie Lucas, Maria Sörhede Winzell, Bo Ahrén, Cecilia Holm, Hindrik Mulder   +5 more
openaire   +1 more source