Results 281 to 290 of about 131,691 (303)

Islet‐cell‐to‐cell communication as basis for normal insulin secretion

Diabetes, Obesity and Metabolism, 2007
The emergence of pancreatic islets has necessitated the development of a signalling system for the intra‐ and inter‐islet coordination of β cells. With evolution, this system has evolved into a complex regulatory network of partially cross‐talking pathways, whereby individual cells sense the state of activity of their neighbours and, accordingly ...
Bavamian S, Klee P, Britan A, Populaire C, Caille D, Cancela J, Charollais A, Meda P   +7 more
openaire   +3 more sources

Regulation of secretory granule pH in insulin-secreting cells

American Journal of Physiology-Cell Physiology, 2002
Luminal acidification is important for the maturation of secretory granules, yet little is known regarding the regulation of pH within them. A pH-sensitive green fluorescent protein (EGFP) was targeted to secretory granules in RIN1046-38 insulinoma cells by using a construct in which the EGFP gene was preceded by the nucleotide sequence for human ...
Linda S, Tompkins, Kevin D, Nullmeyer, Sean M, Murphy, Craig S, Weber, Ronald M, Lynch   +4 more
openaire   +2 more sources

Elusive proximal signals of beta-cells for insulin secretion

Diabetes, 1990
The β-cell is unique because its major agonists, i.e., insulin secretagogues, undergo metabolism instead of interacting with a receptor. This perspectives presents the hypothesis that the first part of a metabolic signal of a secretagogue is specific to the secretagogue and the β-cell and can be envisioned as proximal.
openaire   +2 more sources

Hexose Recognition by Insulin-Secreting BRIN-BD11 Cells

Biochemical and Biophysical Research Communications, 1996
Clonal BRIN-BD11 cells were produced by electrofusion of NEDH rat islet B-cells with immortal RINm5F cells. Western blotting analysis revealed that unlike RINm5F, novel BRIN-BD11 cells expressed high levels of the glucose transport protein GLUT-2, coupled with a rapid and sustained uptake of D-glucose, significantly greater than RINm5F after only 5 min
N H, McClenaghan, A M, Gray, C R, Barnett, P R, Flatt   +3 more
openaire   +2 more sources

Bioartificial Pancreas: Alternative Supply of Insulin‐secreting Cells

Annals of the New York Academy of Sciences, 1999
ABSTRACT: In this study, insulin secretion function of INS‐1 cells immunoisolated in microcapsules was evaluated. Following encapsulation, the immunoisolated INS‐1 cells continued to propagate and flourish within the microcapsules during the entire two‐month in vitro incubation period.
D, Zhou, E, Kintsourashvili, S, Mamujee, I, Vacek, A M, Sun   +4 more
openaire   +2 more sources

Diabetes, Insulin Secretion, and the Pancreatic Beta-Cell Mitochondrion

New England Journal of Medicine, 2001
The mitochondrion of the insulin-secreting pancreatic islet cell is a biochemical beehive in which the products of glucose oxidation influence the secretion of insulin. Work with cultured islets has shown that a mitochondrial ion carrier termed uncoupling protein 2 (UCP2 ) affects glucose-stimulated insulin levels.
openaire   +2 more sources

Insulin-Secreting Cells for Diabetes

Human Gene Therapy, 1999
openaire   +2 more sources

PDX1−/NKX6.1+ progenitors derived from human pluripotent stem cells as a novel source of insulin‐secreting cells

Diabetes/Metabolism Research and Reviews, 2021
Bushra Memon, Ihab Younis, Essam M Abdelalim   +2 more
exaly  

Effect of substrate rigidity in tissue culture on the function of insulin-secreting INS-1E cells

Journal of Tissue Engineering and Regenerative Medicine, 2017
S Lenzen
exaly  

Generation of insulin-secreting cells from human embryonic stem cells

Development Growth and Differentiation, 2006
Hossein Baharvand, Mohammad Massumi
exaly