Bioactivity of Flavonoids on Insulin‐Secreting Cells [PDF]
Comprehensive Reviews in Food Science and Food Safety, 2008 ABSTRACT: Flavonoids are usually found in fruits and other plant organs and therefore widely consumed. They are antioxidants, anti‐inflammatory, anticarcinogenic, and protective against coronary disease and metabolic disorders.
Pinent, Montserrat +5 more
openaire +3 more sources
Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1. [PDF]
PLoS ONE, 2011 BACKGROUND:High fat diet-induced hyperglycemia and palmitate-stimulated apoptosis was prevented by specific inhibition of protein kinase C delta (PKCδ) in β-cells.
Felicia Ranta +11 more
doaj +1 more source
PAX4 promotes PDX1-induced differentiation of mesenchymal stem cells into insulin-secreting cells. [PDF]
Am J Transl Res, 2017 Xu L +10 more
europepmc +2 more sources
Rediscovering Primary Cilia in Pancreatic Islets [PDF]
Diabetes & Metabolism Journal, 2023 Primary cilia are microtubule-based sensory and signaling organelles on the surfaces of most eukaryotic cells. Despite their early description by microscopy studies, islet cilia had not been examined in the functional context until recent decades.
Eun Young Lee, Jing W. Hughes
doaj +1 more source
Overcoming the Limitations of Stem Cell-Derived Beta Cells
Biomolecules, 2022 Great advances in type 1 diabetes (T1D) and type 2 diabetes (T2D) treatment have been made to this day. However, modern diabetes therapy based on insulin injections and cadaveric islets transplantation has many disadvantages.
Mariana V. Karimova +2 more
doaj +1 more source
Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells [PDF]
, 2019 Pancreatic β-cells are sensitive to fluctuations in cholesterol content, which can damage the insulin secretion pathway, contributing to the aetiology of type 2 diabetes mellitus.
Caridis, Anna Maria +4 more
core +1 more source
Design Principles of Pancreatic Islets: Glucose-dependent Coordination of Hormone Pulses [PDF]
, 2015 Pancreatic islets are functional units involved in glucose homeostasis. The multicellular system comprises three main cell types; $\beta$ and $\alpha$ cells reciprocally decrease and increase blood glucose by producing insulin and glucagon pulses, while ...
Hara, Manami +2 more
core +8 more sources
Substantially increased sensitivity of the spot-ELISA for the detection of anti-insulin antibody-secreting cells using a capture antibody and enzyme-conjugated insulin [PDF]
, 1990 This paper describes an antibody capture spot-ELISA for the detection of anti-insulin antibody-secreting cells. The assay is based on the binding of secreted antibodies by immobilised isotype-specific capture antibodies and subsequent detection of ...
Benner, R. (Robbert) +2 more
core +1 more source
Calbindin-D9k Ablation Disrupt Glucose/Pancreatic Insulin Homeostasis. [PDF]
PLoS ONE, 2016 It has been proposed that cellular Ca2+ signals activate hormone secretion. In pancreatic β cells, which produce insulin, Ca2+ signals have been known to contribute to insulin secretion.
Changhwan Ahn +5 more
doaj +1 more source
In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. [PDF]
, 2006 International audienceInsulin-secreting pancreatic beta cells are exceptionally rich in zinc. In these cells, zinc is required for zinc-insulin crystallization within secretory vesicles.
Chimienti, Fabrice +10 more
core +3 more sources