Results 41 to 50 of about 94,888 (208)
A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes
Frontiers in Immunology, 2021 To circumvent the limitations of available preclinical models for the study of type 1 diabetes (T1D), we developed a new humanized model, the YES-RIP-hB7.1 mouse.
Sandrine Luce +20 more
doaj +1 more source
The Cell Physiology of Biphasic Insulin Secretion
Physiology, 2000 Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.
Rorsman, P +5 more
openaire +3 more sources
Mitochondrial Complexes I and II Are More Susceptible to Autophagy Deficiency in Mouse β-Cells [PDF]
Endocrinology and Metabolism, 2015 BackgroundDamaged mitochondria are removed by autophagy. Therefore, impairment of autophagy induces the accumulation of damaged mitochondria and mitochondrial dysfunction in most mammalian cells.
Min Joo Kim +12 more
doaj +1 more source
A role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of langerhans [PDF]
, 2008 Background: The extracellular calcium-sensing receptor (CaR) is expressed in many tissues that are not associated with Ca2+ homeostasis, including the endocrine cells in pancreatic islets of Langerhans.
Burns, Christopher +4 more
core +1 more source
2-Ketoisocaproate transport in insulin-secreting cells
Bioscience Reports, 1992 The transport of the nutrient secretagogue 2-ketoisocaproate (KIC) was studied in isolated rat pancreatic islets and in the HIT-T15 insulinoma cell line using an oil-filtration technique. In both islets and HIT-T15 cells, KIC uptake was a slow process, not reaching equilibrium within 10 min KIC transport was not dependent upon Na+ in the medium, was ...
L, Best, R, Trebilcock, S, Tomlinson
openaire +2 more sources
Human islets contain four distinct subtypes of β cells
Nature Communications, 2016 Dysfunction or loss of insulin-secreting β cells in the pancreas is a hallmark of diabetes. Here, Dorrell et al.identify four subpopulations of β cells in humans, which differ in gene expression and insulin secretion kinetics, and the abundance of which ...
Craig Dorrell +10 more
doaj +1 more source
Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene. [PDF]
, 2019 There has been considerable debate as to whether obesity can act as an accelerator of type 1 diabetes (T1D). We assessed this possibility using transgenic mice (MIP-TF mice) whose ß-cells express enhanced green fluorescent protein (EGFP). Infecting these
Atkinson, Mark A +6 more
core +2 more sources
TRPM2 modulates insulin secretion in pancreatic β-cells [PDF]
Islets, 2011 Insulin secretion from pancreatic β-cells is the primary mechanism by which the body lowers blood glucose concentrations. Glucose is the principal stimulator of insulin secretion, and the primary pathway involved in glucose-stimulated insulin secretion is the ATP-sensitive K+ channel voltage-gated Ca2+ channel-mediated pathway.
Kunitoshi, Uchida, Makoto, Tominaga
openaire +2 more sources
The neuronal K+Cl− co-transporter 2 (Slc12a5) modulates insulin secretion
Scientific Reports, 2017 Intracellular chloride concentration ([Cl−]i) in pancreatic β-cells is kept above electrochemical equilibrium due to the predominant functional presence of Cl− loaders such as the Na+K+2Cl− co-transporter 1 (Slc12a2) over Cl−extruders of unidentified ...
Shams Kursan +8 more
doaj +1 more source
International Journal of Endocrinology, 2012 Islet transplantation is a promising therapy for patients with type 1 diabetes that can provide moment-to-moment metabolic control of glucose and allow them to achieve insulin independence. However, two major problems need to be overcome: (1) detrimental
Feng-Cheng Chou +2 more
doaj +1 more source