Results 81 to 90 of about 97,940 (183)

Ex vivo generation of glucose sensitive insulin secreting mesenchymal stem cells derived from human adipose tissue

Indian Journal of Endocrinology and Metabolism, 2012
Background: Diabetics are incapable of producing insulin/have autoimmune mechanisms making it ineffective to control glucose secretion. We present a prospective study of glucose-sensitive insulin-secreting mesenchymal stem cells (IS-MSC) generated from ...
Shruti D Dave, Aruna V Vanikar, Hargovind L Trivedi   +2 more
doaj   +1 more source

Role of mTOR signaling in tumor microenvironment. An overview [PDF]

, 2018
The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME).
Bazzichetto, Chiara, Bria, Emilio, Ciuffreda, L., Cognetti, F., COGNETTI, FRANCESCO, Conciatori, Fabiana, Falcone, I., Milella, M., Pilotto, Sara   +8 more
core   +2 more sources

A Short-activating RNA Oligonucleotide Targeting the Islet β-cell Transcriptional Factor MafA in CD34+ Cells

Molecular Therapy: Nucleic Acids, 2013
Upon functional loss of insulin producing islet β-cells, some patients with diabetes become dependent on life-long insulin supplementation therapy. Bioengineering surrogate insulin producing cells is an alternative replacement strategy. We have developed
Vikash Reebye, Pål Sætrom, Paul J Mintz, John J Rossi, Noriyuki Kasahara, Georgios Nteliopoulos, Joanna Nicholls, Abdelali Haoudi, Myrtle Gordon, Nagy A Habib   +9 more
doaj   +1 more source

How does thymus infection by coxsackievirus contribute to the pathogenesis of type 1 diabetes?

Frontiers in Immunology, 2015
Through synthesis and presentation of neuroendocrine self-antigens by major histocompatibility complex (MHC) proteins, thymic epithelial cells (TECs) play a crucial role in programming central immune self-tolerance to neuroendocrine functions.
Hélène eMichaux, Henri Joseph Martens, Hela eJaidane, Aymen eHalouani, Didier eHober, Vincent eGEENEN   +5 more
doaj   +1 more source

E-cadherin and cell adhesion: a role in architecture and function in the pancreatic islet [PDF]

, 2007
Background/Aims: The efficient secretion of insulin from beta-cells requires extensive intra-islet communication. The cell surface adhesion protein epithelial (E)-cadherin (ECAD) establishes and maintains epithelial tissues such as the islets of ...
Bamji SX, Braga VMM, Brereton HC, Cabrera O, Collares-Buzato CB, Dahl U, Gareth J. Rogers, Gey GO, Gray E, Hellman B, Hills CE, Hodgkin MN, Kanno Y, Matsuda T, Matthew N. Hodgkin, Musil LS, Paul E. Squires, Piccoli G, Shih DQ, Squires PE, Squires PE, Woodfield RJ   +21 more
core   +1 more source

Interleukin-1β Stimulation of c-Jun NH2-Terminal Kinase Activity in Insulin-Secreting Cells [PDF]

, 2001
Christopher Major, Bryan A. Wolf
openalex   +1 more source

Proteoglycan profiling of human, rat and mouse insulin-secreting cells. [PDF]

Glycobiology, 2021
Nikpour M, Nilsson J, Persson A, Noborn F, Vorontsov E, Larson G.   +5 more
europepmc   +1 more source

Inhibition of miR-146a-5p and miR-8114 in Insulin-Secreting Cells Contributes to the Protection of Melatonin against Stearic Acid-Induced Cellular Senescence by Targeting Mafa. [PDF]

Endocrinol Metab (Seoul), 2022
Su S, Zhao Q, Dan L, Lin Y, Li X, Zhang Y, Yang C, Dong Y, Li X, Regazzi R, Sun C, Chu X, Lu H.   +12 more
europepmc   +1 more source

Plasma Membrane Ca2+-ATPase Overexpression Depletes Both Mitochondrial and Endoplasmic Reticulum Ca2+ Stores and Triggers Apoptosis in Insulin-secreting BRIN-BD11 Cells [PDF]

, 2010
Lin Jiang, Florent Allagnat, Evrard Nguidjoe, Adama Kamagaté, Nathalie Pachera, Jean-Marie Vanderwinden, Marisa Brini, Ernesto Carafoli, Décio L. Eizirik, Alessandra K. Cardozo, André Herchuelz   +10 more
openalex   +1 more source

Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons

Nature Communications, 2019
Glucagon-like peptide 1 (GLP-1) is released from intestinal L-cells following nutrient uptake and enhances insulin release as well as promotes satiety. Here, the authors demonstrate that GLP-1 secreting cells release ATP and that this stimulates nodose ...
Van B. Lu, Juraj Rievaj, Elisabeth A. O’Flaherty, Christopher A. Smith, Ramona Pais, Luke A. Pattison, Gwen Tolhurst, Andrew B. Leiter, David C. Bulmer, Fiona M. Gribble, Frank Reimann   +10 more
doaj   +1 more source