Results 101 to 110 of about 1,058,875 (320)

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

open access: yesAdvanced Biology, EarlyView.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua   +5 more
wiley   +1 more source

Metabolic and reproductive characteristics of replacement beef heifers subjected to an early-weaning regimen involving high-concentrate feeding

open access: yesAnimal, 2017
In an effort to better understand the consequences of early weaning (EW) for replacement beef heifers, a two-phase experiment was conducted investigating the impact on metabolic function and documenting reproductive characteristics.
A.L. Zezeski   +6 more
doaj  

Recent Advances in Enzyme‐based Biofuel Cells Using Glucose Fuel: Achieving High Power Output and Enhanced Operational Stability

open access: yesAdvanced Functional Materials, EarlyView.
Effective electron transfer and stable enzyme immobilization, both between enzymes and host electrodes as well as between adjacent enzymes, are crucial for optimizing the biofuel cell (BFC) performance. Recently, efforts have focused on integrating these strategies with porous host electrodes.
Junha Pak   +3 more
wiley   +1 more source

Modeling the distribution of insulin in pancreas [PDF]

open access: yesarXiv
Maintenance of adequate physical and functional pancreatic $\beta$-cell mass is critical for the prevention or delay of diabetes mellitus. It is well established that insulin potently activates mitogenic and anti-apoptotic signaling cascades in cultured $\beta$-cells.
arxiv  

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

open access: yesAdvanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu   +6 more
wiley   +1 more source

Facilitated permeation of insulin across TR146 cells by cholic acid derivatives-modified elastic bilosomes

open access: yesInternational Journal of Nanomedicine, 2018
Santosh Bashyal,1 Jo-Eun Seo,1 Taekwang Keum,1 Gyubin Noh,1 Young Wook Choi,2 Sangkil Lee1 1College of Pharmacy, Keimyung University, Daegu, Republic of Korea; 2College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea Background: Buccal ...
Bashyal S   +5 more
doaj  

DIETS: Diabetic Insulin Management System in Everyday Life [PDF]

open access: yesarXiv
People with diabetes need insulin delivery to effectively manage their blood glucose levels, especially after meals, because their bodies either do not produce enough insulin or cannot fully utilize it. Accurate insulin delivery starts with estimating the nutrients in meals and is followed by developing a detailed, personalized insulin injection ...
arxiv  

Biologically‐Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium

open access: yesAdvanced Functional Materials, EarlyView.
In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García   +23 more
wiley   +1 more source

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

open access: yesAdvanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee   +6 more
wiley   +1 more source

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