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Introduction. This study aimed at evaluating the efficacy and safety of dapagliflozin in patients with type 2 diabetes (T2D) who also received metformin in clinical practice in Italy. Methods.
Alessandro Scorsone+8 more
doaj +1 more source
Examining the role of insulin in the regulation of cardiovascular health [PDF]
A substantial body of evidence has reported that insulin has direct actions on the cardiovascular system independent of its systemic effects on plasma glucose or lipids.
Salt, Ian P.
core +1 more source
EFFECTS OF INSULIN, GLUCAGON, AND INSULIN/GLUCAGON INFUSIONS ON LIVER MORPHOLOGY AND CELL DIVISION AFTER COMPLETE PORTACAVAL SHUNT IN DOGS [PDF]
Insulin, glucagon, and insulin/glucagon mixtures have been infused for four days into the left portal vein of dogs after portacaval shunt. In the left but not the right liver lobes, insulin alone reduced atrophy, preserved hepatocyte ultrastructure, and ...
Blackard+36 more
core +1 more source
Biosimilar Insulin and Insulin Antibodies [PDF]
The introduction of biosimilar insulins in regulated markets is anticipated to happen in the next few years.1,2 However, biosimilar insulins are already on the market in a number of countries with little or no guidelines for approval of biosimilars and where approval is relatively easy to obtain.
David R. Owens, Lutz Heinemann
openaire +2 more sources
A proanthocyanidin from cinnamomum zeylanicum stimulates phosphorylation of insulin receptor in 3t3-l1 adipocytes [PDF]
Non-insulin-dependent diabetes mellitus is due to in large part to insulin resistance, a state where the target cells are no longer responding to ordinary levels of circulating insulin.
Abdul Majid, Fadzilah Adibah+2 more
core +1 more source
The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver [PDF]
Secreted frizzled-related protein (sFRP) 4 is an adipokine with increased expression in white adipose tissue from obese subjects with type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).
Al-Hasani, Hadi+12 more
core +1 more source
The prevalence of the metabolic syndrome in Portugal: the PORMETS study
Background The PORMETS study was designed to estimate the prevalence of metabolic syndrome and its determinants in the overall and administrative regions of the Portuguese mainland.
Luís Raposo+3 more
doaj +1 more source
Mangosteen Extract Shows a Potent Insulin Sensitizing Effect in Obese Female Patients: A Prospective Randomized Controlled Pilot Study. [PDF]
There is a widely acknowledged association between insulin resistance and obesity/type 2 diabetes (T2DM), and insulin sensitizing treatments have proved effective in preventing diabetes and inducing weight loss.
Addessi, E+11 more
core +2 more sources
Mechanisms of Insulin Action and Insulin Resistance.
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of research into insulin action and resistance has issued. In the intervening century, some discoveries have matured, coalescing into solid and fertile ground for ...
Max C. Petersen, G. Shulman
semanticscholar +1 more source