European lipodystrophy registry: background and structure
Orphanet Journal of Rare Diseases, 2020 Background Lipodystrophy syndromes comprise a group of extremely rare and heterogeneous diseases characterized by a selective loss of adipose tissue in the absence of nutritional deprivation or catabolic state. Because of the rarity of each lipodystrophy
Julia von Schnurbein +24 more
doaj +1 more source
Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. [PDF]
, 2015 Defective hepatic insulin receptor (IR) signalling is a pathogenic manifestation of metabolic disorders including obesity and diabetes. The endo/lysosomal trafficking system may coordinate insulin action and nutrient homeostasis by endocytosis of IR and ...
Burnol, Anne-Françoise +7 more
core +1 more source
Relationship of Vitamin D level with insulin dosage required based on insulin therapy protocol
European Journal of Translational Myology, 2023 The deficiency of vitamin D amongst Iranian people is high and also is related on hyperglycemia. This study aims to evaluate the association of vitamin D levels with the required dose of insulin prescribed based on an insulin therapy protocol in ...
Mohammad Niakan Lahiji +4 more
doaj +1 more source
Deletion of Gpr27 in vivo reduces insulin mRNA but does not result in diabetes. [PDF]
, 2020 Gpr27 is a highly conserved, orphan G protein coupled receptor (GPCR) previously implicated in pancreatic beta cell insulin transcription and glucose-stimulated insulin secretion in vitro. Here, we characterize a whole-body mouse knockout of Gpr27. Gpr27
Chopra, Deeksha G +4 more
core
Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance [PDF]
, 2014 Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on muscle
Aguirre +67 more
core +1 more source
Alternate routes to the cell surface underpin insulin-regulated membrane trafficking of GLUT4 [PDF]
, 2015 Insulin-stimulated delivery of glucose transporters (GLUT4) from specialized intracellular GLUT4 storage vesicles (GSVs) to the surface of fat and muscle cells is central to whole-body glucose.
Bryant, Nia J. +3 more
core +3 more sources
Impaired Insulin Profiles Following a Single Night of Sleep Restriction: The Impact of Acute Sprint Interval Exercise [PDF]
, 2020 Experimental sleep restriction (SR) has demonstrated reduced insulin sensitivity in healthy individuals. Exercise is well-known to be beneficial for metabolic health.
Ellis, Jason +5 more
core +2 more sources
Improvement in Glycemic and Lipid Profiles in Type 2 Diabetics with a 90-Day Ketogenic Diet
Journal of Diabetes Research, 2019 Because low-carbohydrate diets are effective strategies to improve insulin resistance, the hallmark of type 2 diabetes, the purpose of reporting these clinical cases was to reveal the meaningful changes observed in 90 days of low-carbohydrate (LC ...
Chase M. Walton +4 more
doaj +1 more source
Adiponectin and insulin: molecular mechanisms of metabolic disorders
Бюллетень сибирской медицины, 2020 Adiponectin, the most common plasma adipocytokine, plays a crucial metabolic and anti-inflammatory role. With insulin resistance associated with obesity, an increase of adiponectin concentration, which leads to the activation of signaling pathways ...
E. G. Uchasova +3 more
doaj +1 more source
Increased Expression of Syncytin-1 in Skeletal Muscle of Humans With Increased Body Mass Index
Frontiers in Physiology, 2022 Obesity negatively impacts skeletal muscle protein metabolism, and also impairs skeletal muscle maintenance and regeneration. We analyzed muscle biopsy samples from humans with increased body mass index (BMI) (i.e. > 30 kg/m2) and controls (i.e., BMI &
Jayachandran Ravichandran +3 more
doaj +1 more source