Results 61 to 70 of about 1,054,549 (287)
Integration of TGF-β-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells. [PDF]
, 2019 Insulin signaling governs many processes including glucose homeostasis and metabolism, and is therapeutically used to treat hyperglycemia in diabetes. We demonstrated that insulin-induced Akt activation enhances the sensitivity to TGF-β by directing an ...
Budi, Erine H +4 more
core
Urocortin 2 Gene Transfer Improves Glycemic Control and Reduces Retinopathy and Mortality in Murine Insulin Deficiency. [PDF]
, 2020 Type 1 diabetes affects 20 million patients worldwide. Insulin is the primary and commonly the sole therapy for type 1 diabetes. However, only a minority of patients attain the targeted glucose control and reduced adverse events.
Bhargava, Raag +10 more
core
Molecular Oncology, EarlyView.We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić +31 more
wiley +1 more source
Cinnamic Acid Derivatives as Antidiabetics Agents
Indonesian Journal of Chemistry, 2017 Diabetes mellitus is a metabolic disorder of carbohydrate metabolism. Treatment of type II diabetes is usually done by prescribing diet and exercise for the patient however it can also be treated with antidiabetic drugs.
Teni Ernawati +4 more
doaj +1 more source
Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling [PDF]
, 2001 The "metabolic cocktail" comprising glucose-insulin-potassium administrated at reperfusion reduces infarct size in the in vivo rat heart. We propose that insulin is the major component mediating this protection and acts via Akt prosurvival signaling ...
Jonassen, A.K. +3 more
core
Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways [PDF]
, 2018 Chemerin and its G protein-coupled receptor [chemerin receptor 23 (ChemR23)] have been associated with endothelial dysfunction, inflammation, and insulin resistance.
Alves-Lopes, Rheure +9 more
core +1 more source
Molecular Oncology, EarlyView.VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Male infertility is a known risk factor for the development of testicular cancer. In this paper, we analyzed the expression profile of a microRNA panel by real‐time PCR and validated the results by digital PCR. Experimental and bioinformatics analyses allowed us to identify possible biomarkers able to discern men with a higher risk of developing ...
Carmen Ferrara +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa +13 more
wiley +1 more source