Results 61 to 70 of about 2,802,211 (401)

Hypothalamically-Induced Insulin Release and its Potentiation During Oral and Intravenous Glucose Loads [PDF]

, 1984
Male Wistar rats were provided with bilateral cannulas in the lateral hypothalamic area (LHA) and cannulas in the left and right jugular vein. Freely moving rats provided in this way with cannulas were infused with transmitters in the LHA and with ...
A.B. Steffens, Bernstein, Berthoud, Berthoud, Bloom, Bloom, Daniel, De Groot, De Jong, E.C. Lotter, F. Kuipers, Frohman, Frohman, G. Flik, Henquin, Inoue, Iversen, Iversen, Kaneto, Kaneto, Kaneto, Kaneto, Karam, Matsushita, McCaleb, Moltz, P.G.M. Luiten, Robertson, Shimazu, Shimazu, Shimazu, Steffens, Steffens, Strubbe, Strubbe, Strubbe   +35 more
core   +4 more sources

Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs

Nature Biomedical Engineering, 2020
Glucose-responsive insulin delivery systems that mimic pancreatic endocrine function could enhance health and improve quality of life for people with type 1 and type 2 diabetes with reduced β-cell function. However, insulin delivery systems with rapid in
Jicheng Yu, Jinqiang Wang, Yuqi Zhang, Guojun Chen, Weiwei Mao, Yanqi Ye, A. Kahkoska, J. Buse, R. Langer, Zhen Gu   +9 more
semanticscholar   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A [PDF]

, 2014
International audienceAims/Hypothesis: Reduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and polyunsaturated fatty acids (MUFA and PUFA) not only improve ...
A El-Yassimi, A Gray, A Kowluru, A Kowluru, A Soto-Guzman, Alexander Gray, B Xue, C Schmitz-Peiffer, Christopher Lipina, CL Kien, CL Kien, CL Kien, CM Blouin, D Fedor, David Magill, DJ Powell, DJ Powell, E Hajduch, Eric Hajduch, Francesca Nardi, G Boden, H Cao, Harinder S. Hundal, J Chen, JA Chavez, JT Vilquin, Juergen Eckel, K Macrae, KD Copps, L Salvado, L Yuzefovych, LG Gillingham, M Andjelkovic, M Parillo, MM Bradford, MR Junttila, N Dimopoulos, P Seshacharyulu, PJ Eichhorn, R Cazzolli, R Hage Hassan, RA DeFronzo, Rima Hage Hassan, S Stratford, S Turban, SE Kahn, T Coll, T Galbo, T Galbo, V Janssens, XT Feng, Y Mitsumoto, Y Wu   +52 more
core   +8 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b

Cellular & Molecular Biology Letters
Background The trafficking of cargoes from endosomes to the trans-Golgi network requires numerous sequential and coordinated steps. Cargoes are sorted into endosomal-derived carriers that are transported, tethered, and fused to the trans-Golgi network ...
Jérôme Gilleron, Abderrahman Chafik, Sandra Lacas-Gervais, Jean-François Tanti, Mireille Cormont   +4 more
doaj   +1 more source

Assessment of Meal Anticipation for Improving Fully Automated Insulin Delivery in Adults With Type 1 Diabetes [PDF]

, 2023
José Garcia‐Tirado, Patricio Colmegna, Orianne Villard, Jenny L. Diaz, Rebeca Esquivel-Zuniga, Chaitanya L. K. Koravi, Charlotte L. Barnett, Mary C. Oliveri, Morgan Fuller, Sue A. Brown, Mark D. DeBoer, Marc D. Breton   +11 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

The Insulin-Degrading Enzyme from Structure to Allosteric Modulation: New Perspectives for Drug Design [PDF]

, 2023
Grazia Raffaella Tundo, Giuseppe Grasso, Marco Persico, О. В. Ткачук, Francesco Bellia, Alessio Bocedi, Stefano Marini, Mariacristina Parravano, Grazia Graziani, Caterina Fattorusso, Diego Sbardella   +10 more
openalex   +1 more source

Effect of knocking down the insulin receptor on mouse rod responses. [PDF]

, 2015
Previous experiments have shown that the insulin receptor (IR) is expressed in mammalian rods and contributes to the protection of photoreceptors during bright-light exposure.
Fain, Gordon L, Rajala, Ammaji, Rajala, Raju VS, Woodruff, Michael L   +3 more
core   +3 more sources