Results 61 to 70 of about 1,441,623 (217)
Intensive insulin therapy and pentastarch resuscitation in severe sepsis.
New England Journal of Medicine, 2008 BACKGROUND The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids ...
F. Brunkhorst +22 more
semanticscholar +1 more source
Memory-enhancing effects of short-term fasting
The European Zoological Journal, 2020 Many recent reports describe memory-enhancing effects of short-term fasting, but the underlying mechanisms are unknown. In the present study, we demonstrate that the insulin increase occurring during short-term fasting is a key factor in forming the ...
Y. Totani +3 more
doaj +1 more source
Contrasting actions of ginsenosides Rb1 and Rg1 on glucose tolerance in rats
Chinese Journal of Physiology, 2019 Ginsenoside profile of Panax ginseng is changing with season and cultivated soil. Yet, dose-response relationship of main ginsenosides on metabolic measures has not been documented in vivo.
Rungchai Chaunchaiyakul +4 more
doaj +1 more source
Modeling and Optimization of Insulin Injection for Type-1 Diabetes Mellitus Management [PDF]
Diabetes mellitus is a global health crisis characterized by poor blood sugar regulation, impacting millions of people worldwide and leading to severe complications and mortality. Although Type 1 Diabetes Mellitus (T1DM) has a lower number of cases compared to other forms of diabetes, it is often diagnosed at a young age and requires lifelong exogenous
arxiv +1 more source
The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux.
Journal of Clinical Investigation, 2016 Insulin resistance arises when the nutrient storage pathways evolved to maximize efficient energy utilization are exposed to chronic energy surplus. Ectopic lipid accumulation in liver and skeletal muscle triggers pathways that impair insulin signaling ...
V. Samuel, G. Shulman
semanticscholar +1 more source
The insulin superfamily of growth-promoting proteins [PDF]
arXiv, 2007 Recently, structural analysis of the human transferrin and growth hormone (GH) amino acid sequences has unravelled that they harbor a motif identical to a pattern found in viral oncoproteins known to bind the primarily nuclear tumor suppressor retinoblastoma protein (RB).
arxiv
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.
Physiological Reviews, 2018 The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only hormone capable of lowering the blood glucose concentration.
P. Rorsman, F. Ashcroft
semanticscholar +1 more source
Acta Chimica Slovenica, 2020 Insulin is an important anabolic hormone that regulates the metabolism of carbohydrates, lipids and proteins. In this study, a reverse-phase liquid chromatography (RP-LC) method was successfully validated and tested for the encapsulation efficiency assay
Eliete de Souza Von Zuben +4 more
doaj +1 more source
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors
Nature, 2018 Mutations in PIK3CA, which encodes the p110α subunit of the insulin-activated phosphatidylinositol-3 kinase (PI3K), and loss of function mutations in PTEN, which encodes a phosphatase that degrades the phosphoinositide lipids generated by PI3K, are among
B. Hopkins +17 more
semanticscholar +1 more source
Antiproliferative MCR peptides block physical interaction of insulin with retinoblastoma protein (RB) in human lung cancer cells [PDF]
arXiv, 2007 Fifteen years ago, a structural analysis of the hormone insulin and the retinoblastoma tumor suppressor protein (RB) revealed that they may physically interact with one another. Subsequently, an RB peptide corresponding to the proposed RB binding site for insulin was found to recognize full-length insulin in vitro.
arxiv