Results 11 to 20 of about 269,490 (301)

Circulating Anti-Insulin Antibodies Protect Against Nocturnal Hypoglycemia in Patients with Type 2 Diabetes Treated with Long-Acting Insulin Analogues

Diabetology
Background: Long-acting insulin analogues have been widely used in patients with type 2 diabetes with reduced insulin secretion. In these patients, hypoglycemia may occur during the night when they do not consume food.
Tokio Sanke, Yuko Matsuoka, Yoshiki Kadoya, Shoichi Yamada, Eri Tamagawa, Atsuyo Fujita   +5 more
doaj   +2 more sources

Determination of autoantibodies in dogs with diabetes mellitus [PDF]

Veterinary World, 2021
Background and Aim: The classification of diabetes mellitus (DM) in dogs has been controversial as currently canine insulin-dependent DM is classified together with absolute insulin deficiency, non-insulin-dependent DM, and relative insulin deficiency ...
Franco González-Villar, Francisco Pérez-Bravo   +1 more
doaj   +1 more source

Insulin autoimmune syndrome: not just one but two different diseases with therapeutic implications

Endocrinology, Diabetes & Metabolism Case Reports, 2023
We present a young woman with treatment resistant insulin autoimmune syndrome (IAS) with a protracted course. Her serum insulin level was 6945 pmol/l (
Anne Cathrine Parelius Wammer, Ingrid Nermoen, Per Medbøe Thorsby, Nils Bolstad, Kari Lima, Hoa Tran, Ivar Følling   +6 more
doaj   +1 more source

Antibodies to the Mr 64,000 (64K) protein in islet cell antibody positive non-diabetic individuals indicate high risk for impaired Beta-cell function [PDF]

, 1992
A prospective study of a normal childhood population identified 44 islet cell antibody positive individuals. These subjects were typed for HLA DR and DQ alleles and investigated for the presence of antibodies to the Mr 64,000 (64K) islet cell antigen ...
Glück, Michael, Bretzel, Reinhard G., Federlin, Konrad, Seißler, Jochen, Hering, Bernhard J., Böhm, Bernhard Otto, Yassin, Nuha, Scherbaum, Werner A., Richter, Wiltrud   +8 more
core   +1 more source

Prevalence of autoantibodies to the 65- and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus [PDF]

, 1993
We investigated the presence of autoantibodies to baculovirus-expressed human recombinant 65- and 67-kD isoforms of glutamate decarboxylase (GAD65 and GAD67) in insulin-dependent diabetes mellitus (IDDM).
Haubruck, Heinz, H Haubruck, Seißler, Jochen, S Wolfahrt, Heinze, Eberhard, R Holl, Wolfahrt, S., W Northemann, Mauch, Ludwig, W Richter, Northemann, Wolfgang, L Mauch, J Seissler, Richter, Wiltrud, J Amann, Holl, Reinhard, S Bieg, Bieg, Sabine, Amann, J., Scherbaum, Werner A., E Heinze   +20 more
core   +1 more source

Insulin lipohypertrophy: A non-fatal dermatological complication of diabetes mellitus reflecting poor glycemic control

Saudi Journal of Medicine and Medical Sciences, 2013
Lipohypertrophy has been a recognized complication of insulin therapy. Despite improvements in insulin purity and the introduction of recombinant human insulin, its prevalence has remained high particularly in those with a poor glycemic control ...
Ishrat H Dar, Showkat H Dar, Sumayya Wani   +2 more
doaj   +1 more source

Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]

, 1993
The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
Brandt, M., Seißler, Jochen, Jungfer, Herbert, Eiermann, Thomas H., Wolfahrt, S., Endl, Josef, Scherbaum, Werner A., Richter, Wiltrud   +7 more
core   +1 more source

Association between Antibodies to the MR 67,000 Isoform of Glutamate Decarboxylase (GAD) and Type 1 (Insulin-Dependent) Diabetes Mellitus with Coexisting Autoimmune Polyendocrine Syndrome Type II [PDF]

, 1994
By using an immunoprecipitation assay, we analysed reactivity of autoantibodies to human recombinant GAD65 and GAD67 in sera from patients with autoimmune polyendocrine syndrome Type II (APS II) with and without Type 1 (insulin-dependent) diabetes ...
Seißler, Jochen, Bieg, Sabine, Yassin, Nadja, Mauch, Ludwig, Böhm, Bernhard Otto, Northemann, Wolfgang, Scherbaum, Werner A.   +6 more
core   +1 more source

Thyroid Disorder and Association of Insulin Antibodies with Thyroid Antibodies in Children with Type 1 Diabetes Mellitus

Pakistan Journal of Medical Research, 2023
Background: During past decade, type 1 diabetes (T1DM) disease burden has increased among all ages, but the rapid growth was seen in young children.
Muniba Jalil, Mohsina Noor Ibrahim, Sajid Ali, Sidra Saleem, Shahzadi Dilawar, Arit Parkash   +5 more
doaj   +4 more sources

Recombinant human preproinsulin expression, purification and reaction with insulin autoantibodies in sera from patients with insulin-dependent diabetes mellitus [PDF]

, 1993
A novel prokaryotic expression vector pGEX-6T was designed for high-level expression of recombinant fusion protein with a histidine-hexapeptide and glutathione-S-transferase at its N-terminus and the recombinant human preproinsulin at its C-terminus ...
Seißler, Jochen, Mauch, Ludwig, Walter, Michael, Northemann, Wolfgang, Berg, Heike   +4 more
core   +1 more source