Insulin-Responsive Transcription Factors [PDF]
Biomolecules, 2021 The hormone insulin executes its function via binding and activating of the insulin receptor, a receptor tyrosine kinase that is mainly expressed in skeletal muscle, adipocytes, liver, pancreatic β-cells, and in some areas of the central nervous system ...
Gerald Thiel +2 more
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Rapid insulin-dependent endocytosis of the insulin receptor by caveolae in primary adipocytes. [PDF]
PLoS ONE, 2009 BACKGROUND:The insulin receptor is localized in caveolae and is dependent on caveolae or cholesterol for signaling in adipocytes. When stimulated with insulin, the receptor is internalized.
Siri Fagerholm +4 more
doaj +7 more sources
Mitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neurons [PDF]
BMC Neuroscience, 2007 Background Accumulated evidence suggests that hydrogen peroxide (H2O2) generated in cells during insulin stimulation plays an integral role in insulin receptor signal transduction.
Pinelis Vsevolod G +4 more
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Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues. [PDF]
PLoS ONE, 2012 BACKGROUND: Insulin analogues comprising acidic amino acid substitutions at position B10 have previously been shown to display increased mitogenic potencies compared to human insulin and the underlying molecular mechanisms have been subject to much ...
Tine Glendorf +7 more
doaj +5 more sources
The signalling conformation of the insulin receptor ectodomain
Nature Communications, 2018 The insulin receptor plays a key role in many physiological processes, yet how insulin effects receptor signaling at the structural level remains incomplete.
Felix Weis +10 more
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Far-western Blotting Detection of the Binding of Insulin Receptor Substrate to the Insulin Receptor [PDF]
Bio-Protocol, 2023 Far-western blotting, derived from the western blot, has been used to detect interactions between proteins in vitro, such as receptor–ligand interactions.
Jinghua Peng +3 more
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Insulin receptor has tyrosine kinase activity toward Shc in rat liver [PDF]
Brazilian Journal of Medical and Biological Research, 1998 Insulin induces tyrosine phosphorylation of Shc in cell cultures and in insulin-sensitive tissues of the intact rat. However, the ability of insulin receptor (IR) tyrosine kinase to phosphorylate Shc has not been previously demonstrated.
E.V. Páez-Espinosa +3 more
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The novel functions of high-molecular-mass complexes containing insulin receptor substrates in mediation and modulation of insulin-like activities: Emerging concept of diverse function by IRS-associated proteins [PDF]
Frontiers in Endocrinology, 2015 Insulin-like peptides, such as insulin and insulin-like growth factors (IGFs), induce a variety of bioactivities, such as growth, differentiation, survival, increased anabolism and decreased catabolism in many cell types and in vivo.
Fumihiko eHakuno +12 more
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Insulin receptor signaling and glucagon-like peptide 1 effects on pancreatic beta cells [PDF]
, 2017 Glucagon-like peptide-1 (GLP-1) is a potent gluco-incretin hormone, which plays a central role on pancreatic beta cell proliferation, survival and insulin secreting activity and whose analogs are used for treating hyperglycemia in type 2 diabetes ...
Caporarello, Nunzia +3 more
core +7 more sources
Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system
The Journal of Headache and Pain, 2022 Background Clinical observations suggest that hyperinsulinemia and insulin resistance can be associated with migraine headache. In the present study we examined the effect of insulin on transient receptor potential vanilloid 1 (TRPV1) receptor-dependent ...
Judit Rosta +5 more
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