Results 11 to 20 of about 727,371 (257)
Insulin and insulin receptors in rodent brain [PDF]
Diabetologia, 1981 While insulin effects on the central nervous system (CNS) mediated through hypoglycaemia are well known, direct insulin effects on the CNS remain controversial. Recently, we found insulin receptors in all areas of the rat brain, with highest concentrations in the olfactory bulb, cerebral cortex and hypothalamus; all areas involved in feeding.
Jesse Roth +3 more
openaire +4 more sources
Engineering of insulin receptor isoform-selective insulin analogues. [PDF]
PLoS ONE, 2011 BACKGROUND: The insulin receptor (IR) exists in two isoforms, A and B, and the isoform expression pattern is tissue-specific. The C-terminus of the insulin B chain is important for receptor binding and has been shown to contact the IR just adjacent to ...
Tine Glendorf +5 more
doaj +1 more source
Frontiers in Endocrinology, 2022 AimsGlucagon‐like peptide 1 (GLP-1) receptor agonists have demonstrated strong glycemic control. However, few studies have investigated the effects of switching from insulin to GLP-1 receptor agonists.
Youngsook Kim +5 more
doaj +1 more source
The Journal of Pediatrics, 1981 Cells are endowed with specific cognitive molecules that function as receptors for hormones, neurotransmitters, and other intercellular messengers. The receptor molecules may be present in the plasma membrane, cytoplasm, or nucleus. When occupied by the messenger, the receptor is coupled to the cellular machinery that responds to the message-bearing ...
openaire +4 more sources
Scientific Reports, 2022 Extraction of integral membrane proteins with poly(styrene-co-maleic acid) provides a promising alternative to detergent extraction. A major advantage of extraction using copolymers rather than detergent is the retention of the lipid bilayer around the ...
Kerrie A. Morrison +6 more
doaj +1 more source
Effect of knocking down the insulin receptor on mouse rod responses. [PDF]
, 2015 Previous experiments have shown that the insulin receptor (IR) is expressed in mammalian rods and contributes to the protection of photoreceptors during bright-light exposure.
Fain, Gordon L +3 more
core +3 more sources
Onderstepoort Journal of Veterinary Research, 2013 The insulin-like growth factor system (insulin-like growth factor 1, insulin-like growth factor 2, insulin-like growth factor 1 receptor, insulin-like growth factor 2 receptor and six insulin-like growth factor-binding proteins) and insulin are essential
Stephen B. Hughes +3 more
doaj +1 more source
A proanthocyanidin from cinnamomum zeylanicum stimulates phosphorylation of insulin receptor in 3t3-l1 adipocytes [PDF]
, 2006 Non-insulin-dependent diabetes mellitus is due to in large part to insulin resistance, a state where the target cells are no longer responding to ordinary levels of circulating insulin.
Abdul Majid, Fadzilah Adibah +2 more
core +1 more source
Estradiol Binds to Insulin and Insulin Receptor Decreasing Insulin Binding in vitro
Frontiers in Endocrinology, 2014 Rationale: Insulin resistance associated with hyperestrogenemias occurs in gestational diabetes mellitus, polycystic ovary syndrome, ovarian hyperstimulation syndrome, estrogen therapies, metabolic syndrome and obesity.
Robert eRoot-Bernstein +2 more
doaj +1 more source
Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts. [PDF]
, 2014 Insulin and adrenergic stimulation are two divergent regulatory systems that may interact under certain pathophysiological circumstances. Here, we characterized a complex consisting of insulin receptor (IR) and β2-adrenergic receptor (β2AR) in the heart.
Abel, E Dale +14 more
core +2 more sources