Results 11 to 20 of about 3,468,934 (422)
Insulin receptor and cancer. [PDF]
Endocrine-Related Cancer, 2011 The widespread epidemic of obesity and type 2 diabetes has raised concern for the impact of these disorders as risk factors for cancer and has renewed the interest for studies regarding the involvement of hyperinsulinemia and insulin receptor (IR) in ...
A. Belfiore, R. Malaguarnera
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Insulin receptor trafficking steers insulin action
Molecular Metabolism, 2016 In this issue, Boothe and colleagues analyze insulin receptor trafficking in pancreatic beta cells to unravel the trafficking route of insulin receptors and provide novel insights into the potentially different roles of insulin receptor splice variants [1].
Simone Hausmann, Siegfried Ussar
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ISOLATION AND CHARACTERIZATION OF INSULIN RECEPTOR OF PLASMA MEMBRANES OF RAT LIVER CELLS AT MODEL OF TYPE 2 DIABETES [PDF]
Biotechnologia Acta, 2014 The insulin receptor was isolated from the liver cell membranes of control and diabetic rats. The protein purity was controlled by electrophoresis and Western blot.
T. I. Halenova +3 more
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Protein kinase Cε modulates insulin receptor localization and trafficking in mouse embryonic fibroblasts. [PDF]
PLoS ONE, 2013 We have previously shown that deletion of protein kinase C epsilon (PKCε) in mice results in protection against glucose intolerance caused by a high fat diet.
David J Pedersen +3 more
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Engineering of insulin receptor isoform-selective insulin analogues. [PDF]
PLoS ONE, 2011 BACKGROUND: The insulin receptor (IR) exists in two isoforms, A and B, and the isoform expression pattern is tissue-specific. The C-terminus of the insulin B chain is important for receptor binding and has been shown to contact the IR just adjacent to ...
Tine Glendorf +5 more
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Insulin and insulin receptors in rodent brain [PDF]
Diabetologia, 1981 While insulin effects on the central nervous system (CNS) mediated through hypoglycaemia are well known, direct insulin effects on the CNS remain controversial. Recently, we found insulin receptors in all areas of the rat brain, with highest concentrations in the olfactory bulb, cerebral cortex and hypothalamus; all areas involved in feeding.
Jesse Roth +3 more
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The Journal of Pediatrics, 1981 Cells are endowed with specific cognitive molecules that function as receptors for hormones, neurotransmitters, and other intercellular messengers. The receptor molecules may be present in the plasma membrane, cytoplasm, or nucleus. When occupied by the messenger, the receptor is coupled to the cellular machinery that responds to the message-bearing ...
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Onderstepoort Journal of Veterinary Research, 2013 The insulin-like growth factor system (insulin-like growth factor 1, insulin-like growth factor 2, insulin-like growth factor 1 receptor, insulin-like growth factor 2 receptor and six insulin-like growth factor-binding proteins) and insulin are essential
Stephen B. Hughes +3 more
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Frontiers in Endocrinology, 2022 AimsGlucagon‐like peptide 1 (GLP-1) receptor agonists have demonstrated strong glycemic control. However, few studies have investigated the effects of switching from insulin to GLP-1 receptor agonists.
Youngsook Kim +5 more
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