Results 21 to 30 of about 3,468,934 (422)
Effect of knocking down the insulin receptor on mouse rod responses. [PDF]
, 2015 Previous experiments have shown that the insulin receptor (IR) is expressed in mammalian rods and contributes to the protection of photoreceptors during bright-light exposure.
Fain, Gordon L +3 more
core +3 more sources
Journal of Pathology, 2018 Alzheimer's disease (AD) is a devastating neurological disorder that still lacks an effective treatment, and this has stimulated an intense pursuit of disease‐modifying therapeutics.
A. F. Batista +18 more
semanticscholar +1 more source
Structure of the Insulin Receptor-Insulin Complex by Single Particle CryoEM analysis
Nature, 2018 The insulin receptor is a dimeric protein that has a crucial role in controlling glucose homeostasis, regulating lipid, protein and carbohydrate metabolism, and modulating brain neurotransmitter levels.
G. Scapin +9 more
semanticscholar +1 more source
Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022 Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh +5 more
wiley +1 more source
Estradiol Binds to Insulin and Insulin Receptor Decreasing Insulin Binding in vitro
Frontiers in Endocrinology, 2014 Rationale: Insulin resistance associated with hyperestrogenemias occurs in gestational diabetes mellitus, polycystic ovary syndrome, ovarian hyperstimulation syndrome, estrogen therapies, metabolic syndrome and obesity.
Robert eRoot-Bernstein +2 more
doaj +1 more source
Scientific Reports, 2022 Extraction of integral membrane proteins with poly(styrene-co-maleic acid) provides a promising alternative to detergent extraction. A major advantage of extraction using copolymers rather than detergent is the retention of the lipid bilayer around the ...
Kerrie A. Morrison +6 more
doaj +1 more source
A proanthocyanidin from cinnamomum zeylanicum stimulates phosphorylation of insulin receptor in 3t3-l1 adipocytes [PDF]
, 2006 Non-insulin-dependent diabetes mellitus is due to in large part to insulin resistance, a state where the target cells are no longer responding to ordinary levels of circulating insulin.
Abdul Majid, Fadzilah Adibah +2 more
core +1 more source
Insulin transport across the blood–brain barrier can occur independently of the insulin receptor
Journal of Physiology, 2018 Insulin enters the brain from the blood via a saturable transport system. It is unclear how insulin is transported across the blood–brain barrier (BBB).
E. Rhea, C. Rask-Madsen, W. Banks
semanticscholar +1 more source
Revisiting the IGF-1R as a breast cancer target
npj Precision Oncology, 2017 The type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and multiple clinical trials examining insulin-like growth factor-1 receptor have been completed.
Roudy Chiminch Ekyalongo, Douglas Yee
doaj +1 more source
When intensive insulin therapy (MDi) fails in patients with type 2 diabetes: Switching to GLP-1 receptor agonist versus insulin pump [PDF]
, 2016 Treatment with insulin, alone or with oral or injectable hypoglycemic agents, is becoming increasingly common in patients with type 2 diabetes. However, approximately 40% of patients fail to reach their glycemic targets with the initially prescribed ...
Castaneda, Javier +4 more
core +2 more sources