Results 241 to 250 of about 861,807 (357)

Effect of insulin-like growth factor-1 therapy on erythropoetin concentrations in extreme insulin resistance [PDF]

, 1994
John Quin, J P Miell, Karen Smith, David Gordon, Judith A Strachan, John B. Dick, A.C. MacCuish   +6 more
openalex   +1 more source

Lactate‐Activated GPR132‐Src Signal Induces Macrophage Senescence and Aggravates Atherosclerosis Under Diabetes

Advanced Science, EarlyView.
Elevated lactate in diabetes activates the GPR132‐Src pathway in macrophages, inducing macrophage senescence and further enhancing foam cell formation. This mechanism exacerbates atherosclerotic progression. Abstract Diabetes is widely acknowledged as a significant risk factor for atherosclerosis, facilitating plaque formation through various ...
Xiaofeng Ge, Shuying Wang, Zhaokai Li, Jing Yu, Binbin Liu, Ruiying Wang, Shichen Bu, Nawsher wan, Yan Wang, Cuilian Dai, Yijun Lin   +10 more
wiley   +1 more source

Measurement of Insulin Resistance in Cats With Chronic Kidney Disease. [PDF]

Vet Med Sci
Bastan I, Cayiroglu CT, Kaya Kartal Y, Sel T.   +3 more
europepmc   +1 more source

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

Advanced Science, EarlyView.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li, Ya‐Li Zhang, Tong Jin, Zhaokui Jin, Mengliang Zhu, Guangchao Qing, Jinchao Zhang, Zhisen Wang, Yan Mu, Jin Li, Qian Hua, Xing‐Jie Liang   +11 more
wiley   +1 more source

Metabolic Syndrome and Insulin Resistance in Romania. [PDF]

Int J Mol Sci
Ştefan AG, Clenciu D, Mitrea A, Vladu IM, Protasiewicz-Timofticiuc DC, Roşu MM, Maria DT, Dinu IR, Gheonea TC, Vladu BE, Efrem IC, Moţa E, Moţa M.   +12 more
europepmc   +1 more source

The Role of β₂-Adrenoceptor on the Pathogenesis of Insulin Resistance in Essential Hypertension

, 1994
Jinchi KIM, S Shigetomi, Kiyonobu TANAKA, Zen-o Yamada, Shigeatsu Hashimoto, S Fukuchi   +5 more
openalex   +2 more sources

MYC/TET3‐Regulated TMEM65 Activates OXPHOS‐SERPINB3 Pathway to Promote Progression and Cisplatin Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) remains a major challenge in breast cancer management as it lacks effective therapeutic targets. This study uncovers that MYC/TET3‐regulated mitochondrial inner‐membrane protein TMEM65 promotes TNBC progression and cisplatin resistance by activating the OXPHOS‐SERPINB3 pathway and reveals TMEM65 as a potential ...
Yin‐Ling Zhang, Min‐Ying Huang, Shao‐Ying Yang, Jia‐Yang Cai, Qian Zhao, Fang‐Lin Zhang, Xin Hu, Zhi‐Min Shao, Li Liao, A‐Yong Cao, Da‐Qiang Li   +10 more
wiley   +1 more source

Thyrotropin exacerbates insulin resistance by triggering macrophage inflammation in subclinical hypothyroidism. [PDF]

Exp Mol Med
Zhang H, Zeng Z, Liu Y, Zheng W, Wang J, Yao Y, Wang Y, Ji M, Hou P.   +8 more
europepmc   +1 more source

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source

Metabolic and vascular insulin resistance: partners in the pathogenesis of cardiovascular disease in diabetes. [PDF]

Am J Physiol Heart Circ Physiol
Horton WB, Love KM, Gregory JM, Liu Z, Barrett EJ.   +4 more
europepmc   +1 more source