Results 271 to 280 of about 3,853,066 (390)

Insulin resistance and hypertension — implications for treatment

, 1991
PA Rutherford, T. H. Thomas, R. Wilkinson   +2 more
openalex   +1 more source

Multiomics and Systematic Analyses Reveal the Roles of Hemoglobin and the HIF‐1 Pathway in Polycystic Ovary Syndrome

Advanced Science, Volume 12, Issue 14, April 10, 2025.
High‐end normal hemoglobin levels are associated with an increased odds of polycystic ovary syndrome (PCOS), potentially through a mechanism of elevating testosterone levels involving the hypoxia‐inducible factor 1 (HIF‐1) pathway. These findings provide novel insights into the pathophysiology of PCOS and highlight that hemoglobin levels may serve as a
Guiquan Wang, Weian Mao, Yurong Zhang, Haiyan Yang, Ming Zhu, Yan Li, Wei Chen, Yi Chen, Chen Lou, Ping Li, Hsun‐Ming Chang, Shuai Yuan, Yue Zhao, Liangshan Mu   +13 more
wiley   +1 more source

Association of Appendicular Skeletal Muscle Mass Index and Insulin Resistance With Mortality in Multi-Nationwide Cohorts. [PDF]

J Cachexia Sarcopenia Muscle
Moon S, Choi JW, Park JH, Kim DS, Ahn Y, Kim Y, Kong SH, Oh CM.   +7 more
europepmc   +1 more source

CircMETTL6 Suppresses Ovarian Cancer Cell Growth and Metastasis Through Inhibition of GDF15 Transcription by Disrupting the NONO‐POLR2A Complex

Advanced Science, Volume 12, Issue 12, March 27, 2025.
This study identifies a novel circRNA, circMETTL6, downregulated in ovarian cancer, with its reduced expression serving as a prognostic marker for poor outcomes. CircMETTL6 acts as a tumor suppressor by interfering with NONO's interaction with POLR2A, leading to decreased GDF15 transcription.
Mengqian Yu, Mengting Wu, Tao Shen, Qiongzi Qiu, Aoran Luo, Jia Li, Xufan Li, Xiaodong Cheng, Bingjian Lu, Weiguo Lu, Pengyuan Liu, Yan Lu   +11 more
wiley   +1 more source

Comparing the impact of cumulative insulin resistance surrogates exposure on stroke: optimizing prevention strategies. [PDF]

Lipids Health Dis
Hong D, Li X, Sheng G, Yang H, Wang W, Zou Y.   +5 more
europepmc   +1 more source

Skeletal muscle inflammation and insulin resistance in obesity

Journal of Clinical Investigation, 2017
Huaizhu Wu, C. Ballantyne
semanticscholar   +1 more source

RNASET2 Deficiency Induces Hepatocellular Carcinoma Metastasis through Cholesterol‐Triggered MET Activation

Advanced Science, Volume 12, Issue 12, March 27, 2025.
This study elucidates the role of RNASET2 in inhibiting the metastasis of HCC. RNASET2 preferentially cleaves RNA into uridine, which contributes to the salvage synthesis of UTP and the glucuronidation of bile acids, thereby maintaining a balance in cholesterol metabolism. This process is followed by the degradation of MET in the lysosome.
Yanquan Xu, Yu Chen, Jiangang Zhang, Jingchun Wang, Shuai Yang, Huakan Zhao, Lei Wu, Juan Lei, Yu Zhou, Jin Peng, Lu Jiang, Qian Chen, Rong Xin, Jianyun Zhou, Yongsheng Li   +14 more
wiley   +1 more source

Mechanism of insulin resistance in CCl4-induced cirrhosis of rats

, 1992
A. Meyer-Alber, Heinz Hartmann, Frank Stümpel, W. Creutzfeldt   +3 more
openalex   +1 more source

Mitochondrial Amount Determines Doxorubicin‐Induced Cardiotoxicity in Cardiomyocytes

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Using human‐induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs), it is demonstrated that mitochondrial abundance dictates sensitivity to DIC. Mechanistically, doxorubicin treatment elevates ROS, leading to the opening of the mitochondrial permeability transition pore (mPTP), mitochondrial DNA (mtDNA) leakage, and activation of the cGAS ...
Weiyao Xiong, Bin Li, Jianan Pan, Dongjiu Li, Haihua Yuan, Xin Wan, Yanjie Zhang, Lijun Fu, Junfeng Zhang, Ming Lei, Alex Chia Yu Chang   +10 more
wiley   +1 more source

Polymorphisms Involved in Insulin Resistance and Metabolic Inflammation: Influence of Nutrients and Dietary Interventions. [PDF]

Metabolites
Duarte GBS, Pascoal GFL, Rogero MM.
europepmc   +1 more source