Results 271 to 280 of about 951,131 (359)

Lipid Subclasses Differentiate Insulin Resistance by Triglyceride-Glucose Index. [PDF]

Metabolites
Naja K, Anwardeen N, Albagha O, Elrayess MA.   +3 more
europepmc   +1 more source

Insulin resistance and hypertension — implications for treatment

, 1991
PA Rutherford, T. H. Thomas, R. Wilkinson   +2 more
openalex   +1 more source

Acetylation of the Mitochondrial Chaperone GRP75 Governs ER‐Mitochondrial Calcium Homeostasis and Hepatocyte Insulin Resistance

Advanced Science, EarlyView.
Overnutrition exacerbates insulin resistance (IR) and is linked to excessive mitochondrial protein acetylation. However, it remains unclear whether and how mitochondrial protein acetylation influences IR. GCN5L1‐dependent downregulation of GRP75 acetylation at K567/612 consequently enhances ER‐mitochondrial calcium flux and induces ER stress.
Danni Wang, Jiaqi Zhang, Xinyu Yang, Qiqi Zhang, Xiuya Hu, Xin Lu, Hanni Li, Xue Bai, Kai Zhang, Michael N. Sack, Yongsheng Chang, Yingmei Wang, Lingdi Wang, Lu Zhu   +13 more
wiley   +1 more source

The role of insulin resistance in the longitudinal progression from NAFLD to cardiovascular-kidney-metabolic disease. [PDF]

Cardiovasc Diabetol
Hou C, Yuan X, Peng M, Shi X, Yang D, Wang F, Song K, Xu G, Shi J.   +8 more
europepmc   +1 more source

NRF2‐REGγ‐ACADM/KLF15 Signaling Pathway Regulates the Browning of White Adipose Tissue to Modulate Obesity

Advanced Science, EarlyView.
This study identifies that REGγ is elevated in obese adipose tissue. REGγ modulates WAT browning via ubiquitin‐independent ACADM/KLF15–UCP1 degradation. Overactivation of the NRF2–REGγ axis facilitates adipose tissue function to cause obesity. Inhibition of REGγ in the iWAT alleviates HFD‐induced obesity.
Hui Chen, Qiujing Guan, Shuangming Gong, Yingying Du, Zhidan Zhang, Yan Liu, Lei Zhou, Lin Liu, Baoquan Xin, Yilan Guo, Hui Zhang, Ziyang Zhou, Tongchao Pei, Guohong Yu, Sokun Yin, Lei Li   +15 more
wiley   +1 more source

N-lactoyl amino acids are potential biomarkers for insulin resistance and diabetic complications. [PDF]

Diabetes Obes Metab
Naja K, Elashi AA, Anwardeen N, Razzaq A, Hedaya L, Almuraikhy S, Diboun I, Suhre K, AlBagha O, Elrayess MA.   +9 more
europepmc   +1 more source

Transfer Learning and Permutation‐Invariance Improving Predicting Genome‐Wide, Cell‐Specific and Directional Interventions Effects of Complex Systems

Advanced Science, EarlyView.
SETComp, a transfer learning model based on permutation‐invariance, is pre‐trained on single‐compound intervention data and fine‐tuned on complex system (e.g., natural products) data. The model achieves up to 93.86% accuracy on complex system‐cell‐gene association predictions, outperforming the baseline by up to 27.59%.
Boyang Wang, Boyu Pan, Tingyu Zhang, Qingyuan Liu, Shao Li   +4 more
wiley   +1 more source

Is Insulin Resistance an Independent Predictor of Atherosclerosis? [PDF]

J Clin Med
Landowska M, Kałuża B, Watała C, Babula E, Żuk-Łapan A, Woźniak K, Kargul A, Jurek J, Korcz T, Cicha-Brzezińska M, Franek E.   +10 more
europepmc   +1 more source

The Role of β₂-Adrenoceptor on the Pathogenesis of Insulin Resistance in Essential Hypertension

, 1994
Jinchi KIM, S Shigetomi, Kiyonobu TANAKA, Zen-o Yamada, Shigeatsu Hashimoto, S Fukuchi   +5 more
openalex   +2 more sources

Nutritional c‐Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
It is shown that hepatic c‐Fos responds to feeding, altering de novo lipogenesis, glycolysis, and a wide range of steatosis‐associated metabolic signaling pathways. Obesogenic diets cause hepatic c‐Fos overexpression, insulin resistance, and the induction of metabolic reprogramming‐related genes.
Ao Li, Eduardo H. Gilglioni, Wadsen St‐Pierre‐Wijckmans, Leila Hosseinzadeh, Christelle Veyrat‐Durebex, Sumeet Pal Singh, Roberto Coppari, Latifa Bakiri, Esteban N. Gurzov   +8 more
wiley   +1 more source