Results 281 to 290 of about 4,469,131 (358)

Hepatic KLF9 Deficiency Inhibits Dehydroepiandrosterone (DHEA)‐Induced Polycystic Ovary Syndrome via Liver‐Ovary Axis

Advanced Science, EarlyView.
The study shows that liver is a previously unrecognized extraovarian organ that plays a key role about androgen homeostasis in the development of DHEA‐induced PCOS. DHEA is the most common precursor of active androgen, such as DHT, and KLF9 is required for the conversion of DHEA to DHT and hepatic KLF9 might be a potential therapeutic target for PCOS ...
Jianli Song, Zhaoqing Guan, Guiyi Ji, Jing Wang, Xiurui Yan, Yujie Zhang, Yinliang Zhang, Chunfang Ha, Rong Hu, Yongsheng Chang, Yaolin Zhang, Heng Fan   +11 more
wiley   +1 more source

Potentially novel surrogate biomarker for diagnosing insulin resistance in type 2 diabetes. [PDF]

World J Diabetes
Jiang H, Henley D, Jiang FX.
europepmc   +1 more source

Synergistic Promotion of Triple‐Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella‐Derived Glutamate and Platelet Activation

Advanced Science, EarlyView.
Polystyrene nanoplastics (PS‐NPs) administered via oral exposure accelerate triple‐negative breast cancer (TNBC) progression by synergistically modulating gut microbiota‐derived glutamate production and platelet activation. This study uncovers a pivotal crosstalk between microbial metabolites and platelet‐tumor interactions, offering mechanistic ...
Leilei Zhu, Peihao Xu, Mingyuan Zhou, Kewei Li, Shasha Tian, Xuemei Fan, Junling Liu, Baodong Ye, Zhishan Ding, Yingzhi Shen   +9 more
wiley   +1 more source

Prevalence of Polycystic Ovary Syndrome Phenotypes and Their Association With Vitamin D Levels, Insulin Resistance, and Homeostasis Model Assessment of Insulin Resistance in Women With Polycystic Ovary Syndrome: A Cross-Sectional Analysis. [PDF]

Cureus
Bahadur A, Afreen T, Heda A, Mundhra R, Naithani M, Verma R, Ratala ML, Jakhar P, Vishwakarma A, Khan N.   +9 more
europepmc   +1 more source

Skeletal muscle inflammation and insulin resistance in obesity

Journal of Clinical Investigation, 2017
Huaizhu Wu, C. Ballantyne
semanticscholar   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Mechanomedicine for Addressing Skeletal Muscle Insulin Resistance.

Endocr Rev
Wang L, Chang L, Ma Y, Jia Y, Gao B, Cui W, Xu F.   +6 more
europepmc   +1 more source

Association of metabolic score for insulin resistance and preeclampsia: a multicenter cohort study. [PDF]

Lipids Health Dis
Li Q, Yan J, Zhao C, Li M, Gu Y, Wang B, Pang Y, Yue C.   +7 more
europepmc   +1 more source

Thyroid Hormone Receptor β1 and PGC1α Coordinately Regulate OPA1/MFN2‐Mediated Mitochondrial Fusion and UCP1‐Mediated Lipid Browning in ccRCC

Advanced Science, EarlyView.
Thyroid hormone receptor β1 (TRβ) downregulation correlates with poor prognosis in clear cell renal cell carcinoma (ccRCC). Restoration of TRβ and the peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha suppresses tumor progression in ccRCC through Uncoupling protein 1 mediated tumor cell “slimming” and optic atrophy 1/mitofusin 2 ...
Xiangui Meng, Tiexi Yu, Fang Lv, Weiquan Li, Hongmei Yang, Xiaoping Zhang, Wen Xiao   +6 more
wiley   +1 more source

Skeletal muscle insulin resistance in prediabetes: a lipidomic perspective on diacylglycerols, ceramides, and phospholipids. [PDF]

Sci Rep
Markova I, Hüttl M, Šťastný J, Zapletalova I, Kačer P, Hönig V, Kacerova T, Malinska H.   +7 more
europepmc   +1 more source