Results 281 to 290 of about 4,252,621 (405)

The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression

Advanced Science, EarlyView.
LC‐GABA neurons exhibit elevated activity to noxious and aversive stimuli in chronic pain, and their activation alleviates pain‐ and depression‐like behaviors. While LC‐GABA neurons target LC‐NA neurons and GABA and Glu neurons in the vlPAG, they modulate the pain responses of LC‐NA neurons but regulate pain‐ and depression‐like behaviors through their
Yuan Gao, Xue Zhang, Xiao‐Juan Liu, Yi‐Ling Sun, Cui Yin, Dong‐Liang Tang, Cheng Xiao, Chunyi Zhou   +7 more
wiley   +1 more source

Microbial metabolism mediates the deteriorative effects of sedentary behaviour on insulin resistance. [PDF]

Clin Transl Med
Ju J, He J, Ye B, Li S, Zhao J, Chen W, Zhang Q, Zhao W, Yang J, Liu L, Li Y, Xia M, Liu Y.   +12 more
europepmc   +1 more source

HPD is an RNA‐Binding Protein Sustaining Ovarian Cancer Cell Glycolysis, Tumor Growth, and Drug Resistance

Advanced Science, EarlyView.
HPD is identified as an RNA‐binding protein that promotes mRNA translation by binding to RRACH motifs via its double‐stranded RNA‐binding domains. This RNA‐binding activity critically sustains glycolysis in ovarian cancer cells. Disrupting HPD's RNA‐binding function effectively suppresses tumor growth and enhances therapeutic sensitivity, highlighting ...
Fei Xie, Han Zhang, Xintong Dai, Mengxin Tu, Chenxi Yu, Lumeng Liu, Yajuan Guo, Huanran Sun, Qingle Gao, Jiyan Wang, Mingming Sun, Qijun Zhang, Taoyuan Wang, Tao He, Zhen Li, Yanping Li, Tao Wang, Jianguo Zhao, Zhongjie Chen, Chunze Zhang, Shuai Zhang, Changliang Shan   +21 more
wiley   +1 more source

Mechanism of insulin resistance in CCl4-induced cirrhosis of rats

, 1992
A. Meyer-Alber, Heinz Hartmann, Frank Stümpel, W. Creutzfeldt   +3 more
openalex   +1 more source

Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy

Nature Reviews Endocrinology, 2016
Guanghong Jia, V. DeMarco, J. Sowers
semanticscholar   +1 more source

SNORA74A Drives Self‐Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis Through Activation of Notch3 Signaling

Advanced Science, EarlyView.
Abstract Liver cancer stem cells (CSCs) account for tumor initiation, heterogeneity and therapy resistance. However, the role of small nucleolar RNAs (snoRNAs) in the regulation of liver CSCs remains largely unclear. Here, this work identifies a conserved H/ACA box snoRNA SNORA74A which is highly expressed in liver CSCs.
Ziheng Zhou, Yang Gu, Zhibin Yi, Jianyi Wang, Zhen Xiong, Hui Guo, Ying Du, Xiaoxiao Zhu, Lei He, Weizheng Ren, Yong Tian, Yanying Wang, Zusen Fan   +12 more
wiley   +1 more source

Insulin resistance in type 1 diabetes is a key modulator of platelet hyperreactivity. [PDF]

Diabetologia
Sagar RC, Yates DM, Pearson SM, Kietsiriroje N, Hindle MS, Cheah LT, Webb BA, Ajjan RA, Naseem KM.   +8 more
europepmc   +1 more source

The E3 Ligase NEDD4L Prevents Colorectal Cancer Liver Metastasis via Degradation of PRMT5 to Inhibit the AKT/mTOR Signaling Pathway

Advanced Science, EarlyView.
Neural precursor cell expressed developmentally down‐regulated gene 4‐like (NEDD4L) prevents colorectal cancer liver metastasis through ubiquitination and degradation of protein arginine methyltransferase 5 (PRMT5). PRMT5 degradation attenuates the methylarginine of AKT1.
Zhewen Dong, Xiaofei She, Junxian Ma, Qian Chen, Yaqun Gao, Ruiyan Chen, Huanlong Qin, Bing Shen, Hua Gao   +8 more
wiley   +1 more source

Periodontitis Frequently Exists in Patients with Colorectal Carcinoma and Causes Supplementary Impairment of Insulin Resistance. [PDF]

Metabolites
Zivkovic M, Boban M, Vrazic D, Vulic I, Budimir I, Blazevic N, Vcev A, Nikolic M.   +7 more
europepmc   +1 more source

An Arg for Gly substitution at position 31 in the insulin receptor, linked to insulin resistance, inhibits receptor processing and transport.

, 1992
Eric R. van der Vorm, G C van der Zon, William H. Meller, H. M. J. Krans, Dick Lindhout, J. A. Maassen   +5 more
openalex   +1 more source