Results 1 to 10 of about 458,144 (260)
Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals [PDF]
, 2017 To evaluate if plasma kisspeptin concentrations are associated with insulin secretion, as suggested by recent in vitro studies, independently of confounders. 261 nondiabetic subjects were stratified into tertiles according to kisspeptin values.
Andreozzi, F +5 more
core +10 more sources
THE HYPOPHYSIS AND SECRETION OF INSULIN [PDF]
Journal of Experimental Medicine, 1942 The ability of the pancreas, from various types of dogs, to correct diabetic hyperglycemia has been studied (Table XI). The pancreas from one animal was united by a vascular union with the neck blood vessels of another dog which had been pancreatectomized for 20 hours. The time necessary to reduce the blood sugar level to 120 mg.
Houssay, Bernardo Alberto +4 more
openaire +4 more sources
Intra-islet GLP-1, but not CCK, is necessary for β-cell function in mouse and human islets [PDF]
, 2020 Glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK) are gut-derived peptide hormones known to play important roles in the regulation of gastrointestinal motility and secretion, appetite, and food intake.
Davis, Dawn +7 more
core +1 more source
Calmodulin and insulin secretion [PDF]
Diabetologia, 1982 It is clear that calcium ions are of considerable importance as a second messenger in insulin secretion. There is increasing evidence that calmodulin, a ubiquitous intracellular regulatory protein that mediates calcium-dependent processes, has a fundamental role in stimulus-secretion coupling.
Barry L. Brown +2 more
openaire +3 more sources
E-cadherin and cell adhesion: a role in architecture and function in the pancreatic islet [PDF]
, 2007 Background/Aims: The efficient secretion of insulin from beta-cells requires extensive intra-islet communication. The cell surface adhesion protein epithelial (E)-cadherin (ECAD) establishes and maintains epithelial tissues such as the islets of ...
Bamji SX +21 more
core +1 more source
Diabetologia, 1981 Aspects of insulin secretory mechanisms and models of diabetogenic B cell damage are discussed. Measurements of fluxes of 3H-labelled triphenylmethylphosphonium ion, 86Rb+, 42K+, 22Na+, and 45Ca2+ in isolated islets indicate that the triggering of insulin release depends on alterations in the interaction of ions with the B cells.
openaire +3 more sources
Insulin-like growth factor-1 is a negative modulator of glucagon secretion [PDF]
, 2017 Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose.
Andreozzi, F +6 more
core +1 more source
Deoxysugars and Insulin Secretion
Hormone and Metabolic Research, 1977 It has been shown that a deoxysugar, D(+)-digitoxose, inhibits glucose-induced insulin release without inhibiting the glucose oxidation rates of the islets. In the present study the effect on insulin release of several other common deoxysugar (L-fucose, D-fucose, L-rhamnose, 2-deoxy-D-galactose and 2-deoxy-D-ribose) was investigated. We have found that
García-Hermida, Ofelia +1 more
openaire +4 more sources
Catechol estrogens stimulate insulin secretion in pancreatic β-cells via activation of the transient receptor potential A1 (TRPA1) channel [PDF]
, 2019 Estrogen hormones play an important role in controlling glucose homeostasis and pancreatic β-cell function. Despite the significance of estrogen hormones for regulation of glucose metabolism, little is known about the roles of endogenous estrogen ...
Cabrera, Over +7 more
core +1 more source
Measuring β-cell function in vivo to understand the pathophysiology of type 2 diabetes [PDF]
, 2014 Diabetes arises when insulin secretion is inadequate for the prevailing metabolic conditions. As such appropriate measurement of β-cell function is necessary for a better understanding of the pathophysiology of prediabetes and diabetes.
Farrugia, Luca P., Vella, Adrian
core +1 more source