Results 1 to 10 of about 271,085 (312)

Myricetin Amplifies Glucose–Stimulated Insulin Secretion via the cAMP-PKA-Epac-2 Signaling Cascade [PDF]

Biomedicines
Aim: Myricetin, a natural bioflavonoid, is reported as an anti-diabetic agent since it possesses the ability to inhibit α-glucosidase activity, stimulate insulin action and secretion, manage ROS, and prevent diabetes complications.
Akhtar Ali, Zahida Memon, Abdul Hameed, Zaheer Ul-Haq, Muneeb Ali, Rahman M. Hafizur   +5 more
doaj   +2 more sources

Insulin Secretion in Malignant Hyperpyrexia [PDF]

BMJ, 1974
An increased glucose-induced insulin response has been observed in patients susceptible to malignant hyperpyrexia. This raises the possibility that the membrane abnormality present in the calcium-storing membranes in the muscle cell in malignant hyperpyrexia may be present also in the beta cell of the pancreas.
M. A. Denborough, Garry L. Warne, R. F. W. Moulds, P. Tse, F. I. R. Martin   +4 more
openalex   +5 more sources

Age-Related Glucose Intolerance Is Associated with Impaired Insulin Secretion in Community-Dwelling Japanese Adults: The Kumamoto Koshi Study [PDF]

Biomedicines
Background/Objectives: Glucose tolerance progressively declines with age. However, the effects of aging on insulin secretion and insulin sensitivity in Japanese subjects are unclear.
Kazuki Fukuda, Masaki Haneda, Naoto Kubota, Eiichi Araki, Kazuya Yamagata   +4 more
doaj   +2 more sources

Molecular and Cellular Bases of Lipodystrophy Syndromes

Frontiers in Endocrinology, 2022
Lipodystrophy syndromes are rare diseases originating from a generalized or partial loss of adipose tissue. Adipose tissue dysfunction results from heterogeneous genetic or acquired causes, but leads to similar metabolic complications with insulin ...
Jamila Zammouri, Camille Vatier, Camille Vatier, Emilie Capel, Martine Auclair, Caroline Storey-London, Elise Bismuth, Héléna Mosbah, Héléna Mosbah, Bruno Donadille, Bruno Donadille, Sonja Janmaat, Sonja Janmaat, Bruno Fève, Bruno Fève, Isabelle Jéru, Isabelle Jéru, Isabelle Jéru, Corinne Vigouroux, Corinne Vigouroux, Corinne Vigouroux   +20 more
doaj   +1 more source

Pregnancy in Women With Monogenic Diabetes due to Pathogenic Variants of the Glucokinase Gene: Lessons and Challenges

Frontiers in Endocrinology, 2022
Heterozygous loss-of-function variants of the glucokinase (GCK) gene are responsible for a subtype of maturity-onset diabetes of the young (MODY). GCK-MODY is characterized by a mild hyperglycemia, mainly due to a higher blood glucose threshold for ...
José Timsit, José Timsit, José Timsit, Cécile Ciangura, Cécile Ciangura, Cécile Ciangura, Danièle Dubois-Laforgue, Danièle Dubois-Laforgue, Danièle Dubois-Laforgue, Danièle Dubois-Laforgue, Cécile Saint-Martin, Cécile Saint-Martin, Christine Bellanne-Chantelot, Christine Bellanne-Chantelot, Christine Bellanne-Chantelot   +14 more
doaj   +1 more source

Dunnigan lipodystrophy syndrome: French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins)

Orphanet Journal of Rare Diseases, 2022
Dunnigan syndrome, or Familial Partial Lipodystrophy type 2 (FPLD2; ORPHA 2348), is a rare autosomal dominant disorder due to pathogenic variants of the LMNA gene. The objective of the French National Diagnosis and Care Protocol (PNDS; Protocole National
H. Mosbah, B. Donadille, C. Vatier, S. Janmaat, M. Atlan, C. Badens, P. Barat, S. Béliard, J. Beltrand, R. Ben Yaou, E. Bismuth, F. Boccara, B. Cariou, M. Chaouat, G. Charriot, S. Christin-Maitre, M. De Kerdanet, B. Delemer, E. Disse, N. Dubois, B. Eymard, B. Fève, O. Lascols, P. Mathurin, E. Nobécourt, A. Poujol-Robert, G. Prevost, P. Richard, J. Sellam, I. Tauveron, D. Treboz, B. Vergès, V. Vermot-Desroches, K. Wahbi, I. Jéru, M. C. Vantyghem, C. Vigouroux   +36 more
doaj   +1 more source

THE HYPOPHYSIS AND SECRETION OF INSULIN [PDF]

Journal of Experimental Medicine, 1942
The ability of the pancreas, from various types of dogs, to correct diabetic hyperglycemia has been studied (Table XI). The pancreas from one animal was united by a vascular union with the neck blood vessels of another dog which had been pancreatectomized for 20 hours. The time necessary to reduce the blood sugar level to 120 mg.
Houssay, Bernardo Alberto, Foglia, Virgilio G., Smyth, F. S., Rietti, Ciro T., Houssay, Alberto B.   +4 more
openaire   +4 more sources

MiR-184 regulates insulin secretion through repression of Slc25a22 [PDF]

PeerJ, 2013
Insulin secretion from pancreatic β-cells plays an essential role in blood glucose homeostasis and type 2 diabetes. Many genes are involved in the secretion of insulin and most of these genes can be targeted by microRNAs (miRNAs).
Sumiyo Morita, Takuro Horii, Mika Kimura, Izuho Hatada   +3 more
doaj   +2 more sources

Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)

Metabolites, 2021
Insulin resistance and insufficient insulin secretion are well-recognized contributors to type 2 diabetes. A potential role of reduced insulin clearance has been suggested, but few studies have investigated the contribution of insulin clearance while ...
Alexis C. Wood, Elizabeth T. Jensen, Alain G. Bertoni, Gautam Ramesh, Stephen S. Rich, Jerome I. Rotter, Yii-Der I. Chen, Mark O. Goodarzi   +7 more
doaj   +1 more source

Assessment of the Role of Metabolic Determinants on the Relationship between Insulin Sensitivity and Secretion. [PDF]

PLoS ONE, 2016
BACKGROUND:Insulin secretion correlates inversely with insulin sensitivity, which may suggest the existence of a crosstalk between peripheral organs and pancreas.
Jose E Galgani, Carmen Gómez, Maria L Mizgier, Juan Gutierrez, Jose L Santos, Pablo Olmos, Andrea Mari   +6 more
doaj   +1 more source