Results 161 to 170 of about 307,626 (315)

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

Elexacaftor-tezacaftor-ivacaftor enhances first-phase insulin secretion and improves glucose control in cystic fibrosis. [PDF]

Endocr Connect
Edlund A, Lindberg U, Fagher K, Påhlman LI.   +3 more
europepmc   +1 more source

Chromium and insulin secretion [PDF]

Diabetologia, 1980
openaire   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Baseline Insulin Secretion Determines Response to Abatacept in Stage 1 Type 1 Diabetes. [PDF]

Diabetes
Galderisi A, Carr ALJ, Taylor P, Bonet J, Cuthbertson D, Sosenko J, Sims EK, Evans-Molina C, Dalla Man C, Ismail HM, Nathan B, Petrelli A, Senior P, Sherr JL, Herold KC, Russell WE, Moran A, Dayan C.   +17 more
europepmc   +1 more source

Dehydroepiandrosterone increases β‐cell mass and improves the glucose‐induced insulin secretion by pancreatic islets from aged rats [PDF]

, 2005
Mayrin Correa Medina, L C. Souza, Luciana C. Caperuto, Gabriel Forato Anhê, Angélica M. Amanso, Vicente P. A. Teixeira, Silvana Bordin, Ângelo Rafael Carpinelli, Luiz Roberto Britto, Renato L. Barbieri, Maria Inês Borella, Carla Roberta de Oliveira Carvalho   +11 more
openalex   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

ERp46 mitigates lipotoxic ER stress to preserve GLUT2 expression and insulin secretion in β-cells. [PDF]

Biomed Rep
Chen D, Chen X, Tian Y, Wang K, Han C.
europepmc   +1 more source

Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin [PDF]

, 2014
Guisheng Zhou, Jim Sinnett-Smith, Shi‐He Liu, Juehua Yu, James X. Wu, Robbi Sanchez, Stephen J. Pandol, Ravinder Abrol, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi   +10 more
openalex   +1 more source