Results 161 to 170 of about 458,144 (260)

Transient Anti-Glutamic Acid Decarboxylase (GAD) Antibody Positivity and Insulin Secretion Reduction After IVIg in Type 2 Diabetes Mellitus. [PDF]

Cureus
Nakashima H, Omura T, Teng X, Kamihara T, Yokoi K, Kawashima S, Tokuda H.   +6 more
europepmc   +1 more source

Aberrant glycosylation of IgG in children with active lupus nephritis alters podocyte metabolism and causes podocyte injury

Arthritis &Rheumatology, Accepted Article.
Background Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes and decreased nephrin production.
Rhea Bhargava, Rohit Upadhyay, Cong Zhao, Prasad Katakam, Scott Wenderfer, Jing Chen, Hua He, Richard Cummings, Maria G. Tsokos, George C. Tsokos   +9 more
wiley   +1 more source

Reduced circulating sphingolipids and <i>CERS2</i> activity are linked to T2D risk and impaired insulin secretion. [PDF]

Sci Adv
Khan SR, Ye WW, Van JAD, Singh I, Rabiee Y, Rodricks KL, Zhang X, Nicholson RJ, Razani B, Summers SA, Futerman AH, Gunderson EP, Wheeler MB.   +12 more
europepmc   +1 more source

Oral paltusotine, a nonpeptide selective somatostatin receptor 2 agonist: Mass balance, absolute bioavailability and metabolism in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paltusotine is a novel, nonpeptide, selective somatostatin receptor 2 agonist in development for the treatment of acromegaly and carcinoid syndrome. This study investigated the mass balance, routes of excretion, absolute bioavailability and metabolite profile of orally administered paltusotine.
Rosa Luo, Ajay Madan, Christine T. Ferrara‐Cook, Deepak Dalvie, Lance Goulet, R. Scott Struthers, Alan S. Krasner   +6 more
wiley   +1 more source

Insulin Sensitivity and Insulin Secretion in Adults With Friedreich's Ataxia: The Role of Skeletal Muscle.

J Clin Endocrinol Metab
Tamaroff J, Nguyen S, Wilson NE, Stefanovski D, Xiao R, Scattergood T, Capiola C, Schur GM, Dunn J, Dedio A, Wade K, Shah H, Sharma R, Mootha VK, Kelly A, Lin KY, Lynch DR, Reddy R, Rickels MR, McCormack SE.   +19 more
europepmc   +1 more source

Alterations of appetite‐regulating hormones in risperidone treated children and adolescents—a post hoc analysis of the SPACe study

British Journal of Clinical Pharmacology, EarlyView.
Weight gain and metabolic disruptions are common in children and adolescents treated with antipsychotics, but the underlying mechanisms are unclear, complicating prevention and treatment. This study examines the impact of risperidone on appetite‐regulating hormones (insulin, leptin and bioleptin) and their relationship to body weight changes over time.
Jiayi Liang, Brenda C. M. de Winter, Rebecca A. Hermans, Sanne M. Kloosterboer, Susanne Kuckuck, Izgi Bayraktar, Liesbeth F. C. van Rossum, Manon H. J. Hillegers, Sander A. A. van den Berg, Birgit C. P. Koch, Bram Dierckx   +10 more
wiley   +1 more source

ETV2 Overexpression Promotes Efficient Differentiation of Pluripotent Stem Cells to Endothelial Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Differentiating endothelial cells (ECs) from human pluripotent stem cells (hPSCs) typically takes 2 weeks and requires parameter optimization. Overexpression of cell type‐specific transcription factors in hPSCs has shown efficient differentiation into various cell types.
Yunfeng Ding, Soniya Tamhankar, Feifan Du, Tessa Christopherson, Nate Schlueter, Jenna R. Cohen, Eric V. Shusta, Sean P. Palecek   +7 more
wiley   +1 more source

In-silico modelling of insulin secretion and pancreatic beta-cell function for clinical applications: is it worth the effort? [PDF]

Front Clin Diabetes Healthc
Tura A, Göbl C, El-Tanani M, Rizzo M.
europepmc   +1 more source

Recent advances of nanomaterials in imaging liver fibrosis

BMEMat, EarlyView.
Schematic summary on the latest strategies of liver fibrosis imaging based on various nanomaterials. Abstract Liver fibrosis is a pathological process resulting from prolonged exposure to various injury factors. It is characterized by the abnormal proliferation and activation of hepatic stellate cells and excessive deposition of extracellular matrix ...
Jin Cui, Shuxuan Zhang, Xueli Xu, Ke Ren, Mengzhen Dong, Zhaokun Nie, Yang Xu, Xiaohui Dai, Peng Xu, Shuo Sun, Xinya Zhao, Xiao Sun   +11 more
wiley   +1 more source

Metabolic State Determines Central and Peripheral Mechanisms of Liraglutide-Enhanced Insulin Secretion

Bonner C, Saponaro C, Imbernon M, Louvet I, Deligia E, Chen S, Davies I, Acosta-Montalvo A, Moreno-Lopez M, Wemelle E, Kothagali L, Porteiro B, Auger F, Zubiaga L, Delalleau N, Thevenet J, Mühlemann M, Pasquetti G, Gmyr V, Pfrieger FW, Nogueiras R, Schwaninger M, Rorsman P, Staels B, Kerr-Conte J, Knauf C, Jones B, Pattou F, Prevot V.   +28 more
europepmc   +1 more source