Results 11 to 20 of about 523,944 (309)
Intra-islet GLP-1, but not CCK, is necessary for β-cell function in mouse and human islets [PDF]
, 2020 Glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK) are gut-derived peptide hormones known to play important roles in the regulation of gastrointestinal motility and secretion, appetite, and food intake.
Davis, Dawn +7 more
core +1 more source
Assessment of the Role of Metabolic Determinants on the Relationship between Insulin Sensitivity and Secretion. [PDF]
PLoS ONE, 2016 BACKGROUND:Insulin secretion correlates inversely with insulin sensitivity, which may suggest the existence of a crosstalk between peripheral organs and pancreas.
Jose E Galgani +6 more
doaj +1 more source
Modulation of insulin secretion by RBFOX2-mediated alternative splicing
Nature Communications, 2023 Insulin secretion is a tightly regulated process that is vital for maintaining blood glucose homeostasis. Although the molecular components of insulin granule trafficking and secretion are well established, how they are regulated to rapidly fine-tune ...
Nicole D. Moss +7 more
doaj +1 more source
BMJ Open Diabetes Research & Care, 2021 Introduction It is increasingly recognized that type 2 diabetes (T2D) is a heterogenous disease with ethnic variations. Differences in insulin secretion, insulin resistance and ectopic fat are thought to contribute to these variations.
Stephanie A Amiel +10 more
doaj +1 more source
Molecular Metabolism, 2022 Objectives: Pancreatic beta cells secrete insulin postprandially and during fasting to maintain glucose homeostasis. Although glucose-stimulated insulin secretion (GSIS) has been extensively studied, much less is known about basal insulin secretion. Here,
Liu Yang +11 more
doaj +1 more source
Diabetologia, 1981 Aspects of insulin secretory mechanisms and models of diabetogenic B cell damage are discussed. Measurements of fluxes of 3H-labelled triphenylmethylphosphonium ion, 86Rb+, 42K+, 22Na+, and 45Ca2+ in isolated islets indicate that the triggering of insulin release depends on alterations in the interaction of ions with the B cells.
openaire +2 more sources
Insulin-like growth factor-1 is a negative modulator of glucagon secretion [PDF]
, 2017 Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose.
Andreozzi, F +6 more
core +1 more source
European lipodystrophy registry: background and structure
Orphanet Journal of Rare Diseases, 2020 Background Lipodystrophy syndromes comprise a group of extremely rare and heterogeneous diseases characterized by a selective loss of adipose tissue in the absence of nutritional deprivation or catabolic state. Because of the rarity of each lipodystrophy
Julia von Schnurbein +24 more
doaj +1 more source
E-cadherin and cell adhesion: a role in architecture and function in the pancreatic islet [PDF]
, 2007 Background/Aims: The efficient secretion of insulin from beta-cells requires extensive intra-islet communication. The cell surface adhesion protein epithelial (E)-cadherin (ECAD) establishes and maintains epithelial tissues such as the islets of ...
Bamji SX +21 more
core +1 more source
Deoxysugars and Insulin Secretion
Hormone and Metabolic Research, 1977 It has been shown that a deoxysugar, D(+)-digitoxose, inhibits glucose-induced insulin release without inhibiting the glucose oxidation rates of the islets. In the present study the effect on insulin release of several other common deoxysugar (L-fucose, D-fucose, L-rhamnose, 2-deoxy-D-galactose and 2-deoxy-D-ribose) was investigated. We have found that
García-Hermida, Ofelia +1 more
openaire +3 more sources