Results 11 to 20 of about 271,085 (312)
Patterns of Insulin Secretion During First-Phase Insulin Secretion in Normal Chinese Adults
Frontiers in Endocrinology, 2021 BackgroundThe increase in diabetes worldwide is alarming. Decreased acute insulin response to intravenous glucose tolerance test (IVGTT) during first-phase insulin secretion (FPIS) is a characteristic of diabetes.
Tao Yuan +10 more
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Modulation of insulin secretion by RBFOX2-mediated alternative splicing
Nature Communications, 2023 Insulin secretion is a tightly regulated process that is vital for maintaining blood glucose homeostasis. Although the molecular components of insulin granule trafficking and secretion are well established, how they are regulated to rapidly fine-tune ...
Nicole D. Moss +7 more
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BMJ Open Diabetes Research & Care, 2021 Introduction It is increasingly recognized that type 2 diabetes (T2D) is a heterogenous disease with ethnic variations. Differences in insulin secretion, insulin resistance and ectopic fat are thought to contribute to these variations.
Stephanie A Amiel +10 more
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Calmodulin and insulin secretion [PDF]
Diabetologia, 1982 It is clear that calcium ions are of considerable importance as a second messenger in insulin secretion. There is increasing evidence that calmodulin, a ubiquitous intracellular regulatory protein that mediates calcium-dependent processes, has a fundamental role in stimulus-secretion coupling.
Barry L. Brown +2 more
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European lipodystrophy registry: background and structure
Orphanet Journal of Rare Diseases, 2020 Background Lipodystrophy syndromes comprise a group of extremely rare and heterogeneous diseases characterized by a selective loss of adipose tissue in the absence of nutritional deprivation or catabolic state. Because of the rarity of each lipodystrophy
Julia von Schnurbein +24 more
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Diabetologia, 1981 Aspects of insulin secretory mechanisms and models of diabetogenic B cell damage are discussed. Measurements of fluxes of 3H-labelled triphenylmethylphosphonium ion, 86Rb+, 42K+, 22Na+, and 45Ca2+ in isolated islets indicate that the triggering of insulin release depends on alterations in the interaction of ions with the B cells.
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Metabolites, 2021 Insulin secretion is widely thought to be maximally stimulated in glucose concentrations of 16.7-to-30 mM (300-to-540 mg/dL). However, insulin secretion is seldom tested in hyperglycemia exceeding these levels despite the Guinness World Record being 147 ...
Katherine M. Gerber +5 more
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Deoxysugars and Insulin Secretion
Hormone and Metabolic Research, 1977 It has been shown that a deoxysugar, D(+)-digitoxose, inhibits glucose-induced insulin release without inhibiting the glucose oxidation rates of the islets. In the present study the effect on insulin release of several other common deoxysugar (L-fucose, D-fucose, L-rhamnose, 2-deoxy-D-galactose and 2-deoxy-D-ribose) was investigated. We have found that
García-Hermida, Ofelia +1 more
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BMC Endocrine Disorders, 2012 Background In patients with both Type 1 and Type 2 diabetes endogenous insulin secretion falls with time which changes treatment requirements, however direct measurement of endogenous insulin secretion is rarely performed.
Jones Angus G +6 more
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Experimental Biology and Medicine, 1995 Aging in mammals has often been associated with decreased insulin secretion and a subsequent deterioration in the ability to maintain glucose homeostasis. However, recent studies have demonstrated that factors such as disease, obesity, and physical activity more closely reflect diminished insulin secretion rather than aging per se. Thus, the purpose of
Rodney C. Ruhe +2 more
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