Results 11 to 20 of about 458,144 (260)

A role for the extracellular calcium-sensing receptor in cell-cell communication in pancreatic islets of Langerhans [PDF]

, 2008
Background: The extracellular calcium-sensing receptor (CaR) is expressed in many tissues that are not associated with Ca2+ homeostasis, including the endocrine cells in pancreatic islets of Langerhans.
Burns, Christopher J., Jones, Peter M., Kitsou-Mylona, Isidora, Persaud, Shanta J., Squires, Paul E.   +4 more
core   +1 more source

Aging and Insulin Secretion

Experimental Biology and Medicine, 1995
Aging in mammals has often been associated with decreased insulin secretion and a subsequent deterioration in the ability to maintain glucose homeostasis. However, recent studies have demonstrated that factors such as disease, obesity, and physical activity more closely reflect diminished insulin secretion rather than aging per se. Thus, the purpose of
Rodney C. Ruhe, Roger B. McDonald, M. C. Coordt   +2 more
openaire   +3 more sources

Dynamin Is Functionally Coupled to Insulin Granule Exocytosis [PDF]

, 2007
The insulin granule integral membrane protein marker phogrin-green fluorescent protein was co-localized with insulin in Min6B1 beta-cell secretory granules but did not undergo plasma membrane translocation following glucose stimulation.
Gaisano, HY, Halban, PA, Hou, JC, Leung, YM, Min, L, Pessin, JE, Tomas, A, Watson, RT   +7 more
core   +2 more sources

Anchored phosphatases modulate glucose homeostasis. [PDF]

, 2012
Endocrine release of insulin principally controls glucose homeostasis. Nutrient-induced exocytosis of insulin granules from pancreatic β-cells involves ion channels and mobilization of Ca(2+) and cyclic AMP (cAMP) signalling pathways.
Cirulli, Vincenzo, Dell'Acqua, Mark L, Hinke, Simon A, Jimenez-Caliani, Antonio J, Langeberg, Lorene K, Navedo, Manuel F, Nygren, Patrick J, Santana, L Fernando, Scott, John D, Tengholm, Anders, Tian, Geng, Ulman, Allison, Whiting, Jennifer L   +12 more
core   +1 more source

Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia [PDF]

, 2010
AMPK (AMP-activated protein kinase) signalling plays a key role in whole-body energy homoeostasis, although its precise role in pancreatic β-cell function remains unclear.
Affourtit, Ashcroft, Benoit Viollet, Bosi, Brand, Cantley, Chan, Chang, Choudhury, Claret, Cool, Craig Beall, David Carling, da Silva Xavier, Del Guerra, Dominic J. Withers, Fu, Gleason, Gloyn, Gloyn, Granot, Hind Al-Qassab, Johnson, Kaisa Piipari, Khan, Krauss, Leclerc, Lim, MacDonald, Marchetti, Mark A. Smith, Matschinsky, Meakin, Michael L. J. Ashford, Miki, Mirshamsi, Mukhtar, Nadeene Parker, Ning, Ostenson, Parton, Pi, Richards, Robertson, Salt, Seghers, Thorens, Vincent, Viollet, Viollet, Wajchenberg, Walker, Wang, Wang, Xue, Yamada, Zhang, Zhang, Zhang   +58 more
core   +6 more sources

Phenotypical heterogeneity linked to adipose tissue dysfunction in patients with type 2 diabetes [PDF]

, 2016
Adipose tissue (AT) inflammation leads to increased free fatty acid (FFA) efflux and ectopic fat deposition, but whether AT dysfunction drives selective fat accumulation in specific sites remains unknown.
ANGELICO, Francesco, BARCHETTA, ILARIA, BARONI, Marco Giorgio, BERTOCCINI, LAURA, CATALANO, Carlo, CAVALLO, Maria Gisella, CIMINI, FLAVIA AGATA, DEL VESCOVO, RICCARDO, FRAIOLI, Antonio, Maria Del Ben,, Martino, Michele Di, Morini, Sergio, POLIMENI, LICIA   +12 more
core   +1 more source

[6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice [PDF]

, 2017
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give ...
Akhter, Farjana, Hannan, J.M.A., Hossain, Mohammad Tashnim, Kabir, Ashraf Ul, Mahzabeen, Sinayat, Mohsin, Md. Nurul Absar Bin, Muna, Ishrat Aklima, Razu, Bodiul Alam, Samad, Mehdi Bin, Unnoor, Naziat   +9 more
core   +2 more sources

Sleep Disturbances and Glucose Metabolism in Older Adults: The Cardiovascular Health Study. [PDF]

, 2015
ObjectiveWe examined the associations of symptoms of sleep-disordered breathing (SDB), which was defined as loud snoring, stopping breathing for a while during sleep, and daytime sleepiness, and insomnia with glucose metabolism and incident type 2 ...
Biggs, Mary Lou, Carnethon, Mercedes, Djoussé, Luc, Janszky, Imre, Kaplan, Robert C, Mukamal, Kenneth J, Patel, Sanjay R, Redline, Susan, Robbins, John A, Siscovick, David S, Strand, Linn Beate   +10 more
core   +2 more sources

The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro [PDF]

, 2016
Aims: Diet-derived short chain fatty acids (SCFAs) improve glucose homeostasis in vivo, but the role of individual SCFAs and their mechanisms of action have not been defined.
Bewick, Gavin, Castañera González, Ramón, Chambers, Edward S., Choudhary, Pratik, Frost, Gary, Hill, Thomas, Huang, Guo Cai, Liu, Bo, Maldonado, Inmaculada Ruz, Morrison, Douglas J., Persaud, Shanta J., Pingitore, Attilio, Preston, Tom, Tedford, Catriona, Wallis, Gareth A.   +14 more
core   +4 more sources

Insulin mediated upregulation of the renin angiotensin system in human subcutaneous adipocytes is reduced by Rosiglitazone [PDF]

, 2005
Background: Obesity associated hypertension is likely to be due to multiple mechanisms. Identification of the renin-angiotensin system (RAS) within adipose tissue does, however, suggest a potential causal role for it in obesity-associated hypertension ...
Chetty, Rajkumar, Coppack, Simon, Harte, A. L. (Alison L.), Katz, Jonathan, Kumar, Sudhesh, McTernan, P. G. (Philip G.), Smith, Stephen   +6 more
core   +1 more source