Results 21 to 30 of about 271,085 (312)

Pancreatic islets isolated from β₂ adrenergic receptor knockout mice show reduced insulin secretion in response to nutrients - doi: 10.4025/actascibiolsci.v35i3.15842

Acta Scientiarum: Biological Sciences, 2013
Activation of β2 adrenergic receptors by catecholamine or catecholamine-mimetic substances may enhance insulin secretion. We herein investigated KCl- and nutrient-stimulated insulin secretion in pancreatic islets isolated from β2 knockout (β2KO) mice ...
Anderson Carlos Marçal, Ana Paula Couto Davel, Angelo Rafael Carpinelli, Patrícia Chakur Brum, Luciana Venturini Rossoni, Carla Roberta de Oliveira Carvalho   +5 more
doaj   +1 more source

Rosuvastatin Treatment Affects Both Basal and Glucose-Induced Insulin Secretion in INS-1 832/13 Cells. [PDF]

PLoS ONE, 2016
Rosuvastatin is a member of the statin family. Like the other statins it is prescribed to lower cholesterol levels and thereby reduce the risk of cardiovascular events.
Vishal A Salunkhe, Olof Elvstam, Lena Eliasson, Anna Wendt   +3 more
doaj   +1 more source

Insulin secretion assays in an engineered MIN6 cell line

MethodsX, 2023
Insulin secretion from pancreatic beta cells is crucial for maintaining glucose homeostasis. The murine insulinoma derived MIN6 cell line is commonly used as a model for insulin secretion studies. However, its glucose responsiveness wanes with passaging,
Liu Yang, Wenbiao Chen
doaj  

CRISPR/Cas9 ADCY7 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion

Frontiers in Endocrinology, 2021
AimDespite the enormous efforts to understand Congenital hyperinsulinism (CHI), up to 50% of the patients are genetically unexplained. We aimed to functionally characterize a novel candidate gene in CHI.PatientA 4-month-old boy presented severe ...
Yazeid Alhaidan, Yazeid Alhaidan, Yazeid Alhaidan, Yazeid Alhaidan, Henrik Thybo Christesen, Henrik Thybo Christesen, Henrik Thybo Christesen, Elena Lundberg, Mohammed A. Al Balwi, Mohammed A. Al Balwi, Mohammed A. Al Balwi, Klaus Brusgaard, Klaus Brusgaard, Klaus Brusgaard   +13 more
doaj   +1 more source

Insulin receptor signaling in the GnRH neuron plays a role in the abnormal GnRH pulsatility of obese female mice. [PDF]

PLoS ONE, 2015
Infertility associated with obesity is characterized by abnormal hormone release from reproductive tissues in the hypothalamus, pituitary, and ovary. These tissues maintain insulin sensitivity upon peripheral insulin resistance.
Sara A DiVall, Danny Herrera, Bonnie Sklar, Sheng Wu, Fredric Wondisford, Sally Radovick, Andrew Wolfe   +6 more
doaj   +1 more source

Respiratory Parameters for the Classification of Dysfunctional Insulin Secretion by Pancreatic Islets

Metabolites, 2021
The development of obesity and type 2 diabetes (T2D) has been associated with impaired mitochondrial function. In pancreatic beta (β) cells, mitochondrial energy metabolism plays a central role in triggering and controlling glucose-stimulated insulin ...
Uma D. Kabra, Charles Affourtit, Martin Jastroch   +2 more
doaj   +1 more source

Glutamate is an essential mediator in glutamine‐amplified insulin secretion

Journal of Diabetes Investigation, 2021
Aims/Introduction Glutamine is the most abundant amino acid in the circulation. In this study, we investigated cell signaling in the amplification of insulin secretion by glutamine.
Guirong Han, Harumi Takahashi, Naoya Murao, Ghupurjan Gheni, Norihide Yokoi, Yoshiyuki Hamamoto, Shun‐ichiro Asahara, Yutaka Seino, Yoshiaki Kido, Susumu Seino   +9 more
doaj   +1 more source

Autoantibodies directed against insulin receptor during the course of Castleman disease: a new case reaffirming autoimmune hypoglycemia as a relapse warning signal

European Journal of Case Reports in Internal Medicine
This case study presents the case of a 54-year-old human immunodeficiency virus (HIV)-positive male who developed type B insulin resistance syndrome (TBIRS) in conjunction with a relapse of human herpesvirus 8 (HHV8)-positive multicentric Castleman ...
Xavier Jannot, Martine Auclair, Martin Martinot, Amin Maazouzi, David Boutboul, Corinne Vigouroux, Yannick Dieudonné   +6 more
doaj   +1 more source

Glutamate Acts as a Key Signal Linking Glucose Metabolism to Incretin/cAMP Action to Amplify Insulin Secretion

Cell Reports, 2014
Incretins, hormones released by the gut after meal ingestion, are essential for maintaining systemic glucose homeostasis by stimulating insulin secretion.
Ghupurjan Gheni, Masahito Ogura, Masahiro Iwasaki, Norihide Yokoi, Kohtaro Minami, Yasumune Nakayama, Kazuo Harada, Benoit Hastoy, Xichen Wu, Harumi Takahashi, Kazushi Kimura, Toshiya Matsubara, Ritsuko Hoshikawa, Naoya Hatano, Kenji Sugawara, Tadao Shibasaki, Nobuya Inagaki, Takeshi Bamba, Akira Mizoguchi, Eiichiro Fukusaki, Patrik Rorsman, Susumu Seino   +21 more
doaj   +1 more source

Bromocriptine and insulin secretion

Bioscience Reports, 1982
The dopaminergic drug bromocriptine inhibited the release of insulin from isolated mouse pancreatic islets. The effect was counteracted by haloperidol or pimozide. It is suggested that insulin release may be inhibited through activation of D-2 dopaminergic receptors in the pancreatic beta-cells.
Eva Gagerman, Ezz-Eldin S. M. El-Denshary, Inge-Bert Täljedal, Nabila A. Ismail, Janove Sehlin   +4 more
openaire   +3 more sources