Latest Progress on Tuberculosis and HIV Co‐Infection: A Closer Look at People of Different Ages
Tackling the problem of tuberculosis (TB) and human immunodeficiency virus (HIV) co‐infection is a serious global health concern affecting people of all ages. This review presents the characteristics of both diseases, current treatment and diagnostic guidelines, associated problems, innovations in disease management, and overall effects on global ...
Anna Yusuf Aliyu, Oluwatoyin A. Adeleke
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A high-throughput, non-radioactive microtiter plate assay for activity of the human immunodeficiency virus integrase protein [PDF]
Cornelis Vink+3 more
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Advancing Precision Medicine: Recent Innovations in Gene Editing Technologies
This review article delves into the cutting‐edge advancements in gene editing technology, with a particular focus on prime editor proteins and their engineered variants. The authors provide a thorough examination of recent developments that have addressed key challenges in the field, including improved precision, enhanced editing efficiency, and ...
Abhijith Koodamvetty+1 more
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Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells [PDF]
Robert L. LaFemina+7 more
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ABSTRACT Introduction With the reduction in human immunodeficiency virus (HIV)–related mortality secondary to antiretroviral therapy, chronic medical conditions and age‐related cancers account for a larger proportion of mortality among those with HIV. Cancer risk overall remains elevated in HIV patients, and cancer screening data in this population is ...
Pooja Mude+7 more
wiley +1 more source
The seed as a habitat for microorganisms is as yet under-explored and has quite distinct characteristics as compared to other vegetative plant tissues. In this study, we investigated three closely related P.
Raheleh eSheibani-Tezerji+6 more
doaj +1 more source
Characterization of human immunodeficiency virus type 1 integrase expressed in Escherichia coli and analysis of variants with amino-terminal mutations [PDF]
Karen A. Vincent+3 more
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Significance of constitutive integrase synthesis. [PDF]
One conceivable function for constitutive integrase formation by lambda prophage is to stabilize the inserted state by catalyzing reinsertion of prophages that are accidentally excised. As this hypothesis implies a dynamic equilibrium betwen inserted and noninserted DNA, the existence of such an equilibrium is explored.
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ABSTRACT Introduction Since the advent of highly active antiretroviral therapy (HAART), morbidity and mortality rates associated with human immunodeficiency virus (HIV) have significantly decreased leading to prolonged life span of Individuals living with HIV due to the effectiveness of antiretroviral therapy.
Nadine Mugisha+7 more
wiley +1 more source
Characterization of the Functional Domains of Human Foamy Virus Integrase Using Chimeric Integrases
Retroviral integrases insert viral DNA into target DNA. In this process they recognize their own DNA specifically via functional domains. In order to analyze these functional domains, we constructed six chimeric integrases by swapping domains between HIV-1 and HFV integrases, and two point mutants of HFV integrase.
Hak Sung, Lee+2 more
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