Nature Communications, 2016 The integron integrases have evolved to perform recombination of single and double stranded DNA. Here the authors show that the ancestral pathway is still functional at double stranded sites, revealing the evolution towards the modern resolution pathway.
Jose Antonio Escudero +5 more
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There and turn back again: the application of phage serine integrases in eukaryotic systems [PDF]
Frontiers in Bioengineering and BiotechnologySerine integrases (Ints) have gained prominence and have been extensively used in Synthetic Biology due to their ability to modify DNA sequences. Ints are recombinases encoded by the phage genome and have been used to unidirectionally catalyze an ...
Thais Torquato Sales +7 more
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Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons [PDF]
Mobile DNA, 2011 Background Integrons are found in hundreds of environmental bacterial species, but are mainly known as the agents responsible for the capture and spread of antibiotic-resistance determinants between Gram-negative pathogens.
Cambray Guillaume +9 more
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Effect of
Mobile DNA, 2011 Background Integrons are genetic elements able to integrate and disseminate genes as cassettes by a site-specific recombination mechanism. These elements contain a gene coding for an integrase that carries out recombination by interacting with two ...
Larouche André, Roy Paul H
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Attachment site selection and identity in Bxb1 serine integrase-mediated site-specific recombination. [PDF]
PLoS Genetics, 2013 Phage-encoded serine integrases mediate directionally regulated site-specific recombination between short attP and attB DNA sites without host factor requirements.
Shweta Singh +2 more
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Development of circular AAV cargos for targeted seamless insertion with large serine integrases [PDF]
Molecular Therapy: Methods & Clinical DevelopmentRecent advancements in gene insertion have shifted from DNA-repair-dependent mechanisms to more precise approaches, enhancing safety and predictability for editing outcomes. Integrase-mediated programmable genomic integration (I-PGI) utilizes a DNA cargo
Brett J.G. Estes +12 more
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Integron and its role in antimicrobial resistance: A literature review on some bacterial pathogens [PDF]
Iranian Journal of Basic Medical Sciences, 2021 In recent years, different acquired resistance mechanisms, including transposons, bacteriophages, plasmids, and integrons have been identified as involved in the spread of resistance genes in bacteria.
Parisa Sabbagh +3 more
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Advances in Biomedical and Health Sciences, 2022 Antibiotic resistance genes (ARGs) are classified as emerging environmental pollutants of global public health concern. These ARGs are disseminated through genetic elements such as integrons.
Anthony Ifeanyin Okoh +1 more
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Applications of Serine Integrases in Synthetic Biology over the Past Decade
SynBio, 2023 Serine integrases are emerging as one of the most powerful biological tools for biotechnology. Over the past decade, many research papers have been published on the use of serine integrases in synthetic biology.
Fang Ba +4 more
semanticscholar +1 more source
Systematic Discovery of a New Catalogue of Tyrosine-Type Integrases in Bacterial Genomic Islands
Applied and Environmental Microbiology, 2023 Site-specific recombinases or integrases have high specificity for DNA large fragment integration, which is urgently needed for gene editing. However, known integrases are not sufficient for meeting multiple integrations.
Gang Zhang +7 more
semanticscholar +1 more source