Results 11 to 20 of about 9,111 (181)
Integrase and integration: biochemical activities of HIV-1 integrase [PDF]
Retrovirology, 2008 Integration of retroviral DNA is an obligatory step of retrovirus replication because proviral DNA is the template for productive infection. Integrase, a retroviral enzyme, catalyses integration.
Deprez Eric +4 more
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Bracoviruses recruit host integrases for their integration into caterpillar's genome.
PLoS Genetics, 2021 Some DNA viruses infect host animals usually by integrating their DNAs into the host genome. However, the mechanisms for integration remain largely unknown.
Zehua Wang +11 more
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EMBO reports, 2010 Antiretroviral drugs to prevent integration of the HIV viral genome into chromosomes are undergoing clinical trials, yet they have been developed with an imperfect understanding of their mechanism of action. The recent crystal structure of the major viral protein integrase from a related, little‐known retrovirus, has finally provided insight into how ...
openaire +2 more sources
Phage integrases for the construction and manipulation of transgenic mammals
Reproductive Biology and Endocrinology, 2003 Phage integrases catalyze site-specific, unidirectional recombination between two short att recognition sites. Recombination results in integration when the att sites are present on two different DNA molecules and deletion or inversion when the att sites
Sclimenti Christopher R +5 more
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Frontiers in Microbiology, 2016 In this study, we searched for integrative conjugative elements (ICEs) in chromosomes of 124 strains of Streptococci. These exhaustive analyses revealed 105 putative ICEs and 26 slightly decayed elements that were grouped in 7 distinct families ...
Chloé eAmbroset +13 more
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Directed DNA shuffling of retrovirus and retrotransposon integrase protein domains. [PDF]
PLoS ONE, 2013 Chimeric proteins are used to study protein domain functions and to recombine protein domains for novel or optimal functions. We used a library of chimeric integrase proteins to study DNA integration specificity.
Xiaojie Qi +6 more
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A population‐based temporal logic gate for timing and recording chemical events
Molecular Systems Biology, 2016 Engineered bacterial sensors have potential applications in human health monitoring, environmental chemical detection, and materials biosynthesis. While such bacterial devices have long been engineered to differentiate between combinations of inputs ...
Victoria Hsiao +3 more
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Positioning Diverse Type IV Structures and Functions Within Class 1 CRISPR-Cas Systems
Frontiers in Microbiology, 2021 Type IV CRISPR systems encode CRISPR associated (Cas)-like proteins that combine with small RNAs to form multi-subunit ribonucleoprotein complexes. However, the lack of Cas nucleases, integrases, and other genetic features commonly observed in most ...
Hannah N. Taylor +6 more
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A trade-off between the fitness cost of functional integrases and long-term stability of integrons.
PLoS Pathogens, 2012 Horizontal gene transfer (HGT) plays a major role in bacterial microevolution as evident from the rapid emergence and spread of antimicrobial drug resistance.
Irina Starikova +7 more
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Serine integrase chimeras with activity in E. coli and HeLa cells
Biology Open, 2014 In recent years, application of serine integrases for genomic engineering has increased in popularity. The factor-independence and unidirectionality of these large serine recombinases makes them well suited for reactions such as site-directed vector ...
Alfonso P. Farruggio, Michele P. Calos
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