Results 11 to 20 of about 31,823 (275)

Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation

open access: yesNature Communications, 2016
The integron integrases have evolved to perform recombination of single and double stranded DNA. Here the authors show that the ancestral pathway is still functional at double stranded sites, revealing the evolution towards the modern resolution pathway.
Jose Antonio Escudero   +5 more
doaj   +2 more sources

There and turn back again: the application of phage serine integrases in eukaryotic systems [PDF]

open access: yesFrontiers in Bioengineering and Biotechnology
Serine integrases (Ints) have gained prominence and have been extensively used in Synthetic Biology due to their ability to modify DNA sequences. Ints are recombinases encoded by the phage genome and have been used to unidirectionally catalyze an ...
Thais Torquato Sales   +7 more
doaj   +2 more sources

Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons [PDF]

open access: yesMobile DNA, 2011
Background Integrons are found in hundreds of environmental bacterial species, but are mainly known as the agents responsible for the capture and spread of antibiotic-resistance determinants between Gram-negative pathogens.
Cambray Guillaume   +9 more
doaj   +12 more sources

Effect of attC structure on cassette excision by integron integrases

open access: yesMobile DNA, 2011
Background Integrons are genetic elements able to integrate and disseminate genes as cassettes by a site-specific recombination mechanism. These elements contain a gene coding for an integrase that carries out recombination by interacting with two ...
Larouche André, Roy Paul H
doaj   +2 more sources

Attachment site selection and identity in Bxb1 serine integrase-mediated site-specific recombination. [PDF]

open access: yesPLoS Genetics, 2013
Phage-encoded serine integrases mediate directionally regulated site-specific recombination between short attP and attB DNA sites without host factor requirements.
Shweta Singh   +2 more
doaj   +6 more sources

Development of circular AAV cargos for targeted seamless insertion with large serine integrases [PDF]

open access: yesMolecular Therapy: Methods & Clinical Development
Recent advancements in gene insertion have shifted from DNA-repair-dependent mechanisms to more precise approaches, enhancing safety and predictability for editing outcomes. Integrase-mediated programmable genomic integration (I-PGI) utilizes a DNA cargo
Brett J.G. Estes   +12 more
doaj   +2 more sources

Integron and its role in antimicrobial resistance: A literature review on some bacterial pathogens [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2021
In recent years, different acquired resistance mechanisms, including transposons, bacteriophages, plasmids, and integrons have been identified as involved in the spread of resistance genes in bacteria.
Parisa Sabbagh   +3 more
doaj   +1 more source

Integrons as emerging contaminants facilitating the widespread of antimicrobial resistance in Enterobacteriaceae

open access: yesAdvances in Biomedical and Health Sciences, 2022
Antibiotic resistance genes (ARGs) are classified as emerging environmental pollutants of global public health concern. These ARGs are disseminated through genetic elements such as integrons.
Anthony Ifeanyin Okoh   +1 more
doaj   +1 more source

Applications of Serine Integrases in Synthetic Biology over the Past Decade

open access: yesSynBio, 2023
Serine integrases are emerging as one of the most powerful biological tools for biotechnology. Over the past decade, many research papers have been published on the use of serine integrases in synthetic biology.
Fang Ba   +4 more
semanticscholar   +1 more source

Systematic Discovery of a New Catalogue of Tyrosine-Type Integrases in Bacterial Genomic Islands

open access: yesApplied and Environmental Microbiology, 2023
Site-specific recombinases or integrases have high specificity for DNA large fragment integration, which is urgently needed for gene editing. However, known integrases are not sufficient for meeting multiple integrations.
Gang Zhang   +7 more
semanticscholar   +1 more source

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