Results 21 to 30 of about 13,949 (234)
New Applications for Phage Integrases [PDF]
Journal of Molecular Biology, 2014 Within the last 25 years, bacteriophage integrases have rapidly risen to prominence as genetic tools for a wide range of applications from basic cloning to genome engineering. Serine integrases such as that from ϕC31 and its relatives have found an especially wide range of applications within diverse micro-organisms right through to multi-cellular ...
Fogg, Paul C M +4 more
openaire +5 more sources
Weight gain and integrase inhibitors [PDF]
Current Opinion in Infectious Diseases, 2020 Purpose of review Weight gain and obesity among people living with HIV (PLWH) is a serious problem that occurs often after initiation of antiretroviral therapy but may be worse with integrase strand transfer inhibitors (INSTIs).
Grace A. McComsey, Allison Ross Eckard
openaire +3 more sources
Bracoviruses recruit host integrases for their integration into caterpillar's genome.
PLoS Genetics, 2021 Some DNA viruses infect host animals usually by integrating their DNAs into the host genome. However, the mechanisms for integration remain largely unknown.
Zehua Wang +11 more
doaj +1 more source
A New Freshwater Cyanosiphovirus Harboring Integrase [PDF]
Frontiers in Microbiology, 2018 Pelagic cyanobacteria are key players in the functioning of aquatic ecosystems, and their viruses (cyanophages) potentially affect the abundance and composition of cyanobacterial communities. Yet, there are few well-described freshwater cyanophages relative to their marine counterparts, and in general, few cyanosiphoviruses (family Siphoviridae) have ...
Kevin Xu Zhong +11 more
openaire +8 more sources
EMBO reports, 2010 Antiretroviral drugs to prevent integration of the HIV viral genome into chromosomes are undergoing clinical trials, yet they have been developed with an imperfect understanding of their mechanism of action. The recent crystal structure of the major viral protein integrase from a related, little‐known retrovirus, has finally provided insight into how ...
openaire +2 more sources
Pharmacology of HIV integrase inhibitors [PDF]
Current Opinion in HIV and AIDS, 2012 The purpose of this paper is to review recent and relevant pharmacology data for three HIV integrase inhibitors: raltegravir (marketed), dolutegravir and elvitegravir (both in Phase III drug development).
Angela D. M. Kashuba +2 more
openaire +3 more sources
Immunology &Cell Biology, Volume 101, Issue 1, Page 36-48, January 2023., 2023 Type 1 diabetes is caused by aberrant activation of autoreactive T cells specific for the islet beta cells, but how these cells evade tolerance to become effector T cells is unknown. This study investigated whether islet‐specific T cells are activated in the gut via cross‐reactive bacterial derived peptides (molecular mimicry) or by non‐specific ...
Mirei Okada +7 more
wiley +1 more source
Phage integrases for the construction and manipulation of transgenic mammals
Reproductive Biology and Endocrinology, 2003 Phage integrases catalyze site-specific, unidirectional recombination between two short att recognition sites. Recombination results in integration when the att sites are present on two different DNA molecules and deletion or inversion when the att sites
Sclimenti Christopher R +5 more
doaj +1 more source
Docking Studies on HIV Integrase Inhibitors Based On Potential Ligand Binding Sites [PDF]
International Journal on Bioinformatics & Biosciences, vol. 2, pp.
21-29, 2012, 2012 HIV integrase is a 32 kDa protein produced from the C-terminal portion of the Pol gene product, and is an attractive target for new anti-HIV drugs. Integrase is an enzyme produced by a retrovirus (such as HIV) that enables its genetic material to be integrated into the DNA of the infected cell.
arxiv +1 more source
Frontiers in Microbiology, 2016 In this study, we searched for integrative conjugative elements (ICEs) in chromosomes of 124 strains of Streptococci. These exhaustive analyses revealed 105 putative ICEs and 26 slightly decayed elements that were grouped in 7 distinct families ...
Chloé eAmbroset +13 more
doaj +1 more source