Results 211 to 220 of about 428,561 (236)

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

EBBP-Mediated Integrated Stress Response Attenuates Anthracycline-Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes. [PDF]

Adv Sci (Weinh)
Chen Z, Chen C, Wu Y, Xia Y, Luo R, Shu J, Chen L, Wang Z, Wang C, Huang K.   +9 more
europepmc   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Identification and validation of integrated stress-response-related genes as biomarkers for age-related macular degeneration. [PDF]

Front Mol Biosci
Niu J, Jin L, Hu Y, Wang Y, Hao X, Geng W, Ma R.   +6 more
europepmc   +1 more source

Regulation of translation elongation and integrated stress response in heat-shocked neurons. [PDF]

Cell Rep
Seluzicki CM, Razavi-Mohseni M, Türker F, Patel P, Hua B, Beer MA, Goff L, Margolis SS.   +7 more
europepmc   +1 more source

Serine mistranslation induces the integrated stress response through the P stalk. [PDF]

J Biol Chem
Zhang H, Ling J.
europepmc   +1 more source

Saturated phosphatidic acids induce mTORC1-driven integrated stress response contributing to glucolipotoxicity in hepatocytes. [PDF]

Am J Physiol Gastrointest Liver Physiol
Guo R, Li Y, Jiang Y, Khan MW, Layden BT, Song Z.   +5 more
europepmc   +1 more source

The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer. [PDF]

Cancer Res
Thomas-Jardin S, Suresh S, Arce A, Novaresi N, Deng Q, Stein E, Thomas L, Lewis C, Ahn C, Evers BM, Akbay EA, Salvatierra ME, Lu W, Khan K, Solis Soto LM, Wistuba II, Minna JD, O'Donnell KA.   +17 more
europepmc   +1 more source

Suppression rather than activation of the integrated-stress-response (GCN2-ATF4) pathway extends lifespan in the fly

Götz MS, Hayman DJ, Adams G, Obata F, Simons MJP.   +4 more
europepmc   +1 more source

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DELE1 oligomerization promotes integrated stress response activation

Nature Structural & Molecular Biology, 2022
AbstractMitochondria are dynamic organelles that must continually adapt and respond to cellular stress. Recent studies demonstrated that mitochondrial stress can be relayed from mitochondria to the cytosol by the release of a C-terminal proteolytic fragment of DELE1 that binds to the eIF2α kinase HRI to initiate integrate stress response (ISR ...
Jie Yang, Kelsey R. Baron, Daniel E. Pride, Anette Schneemann, Xiaoyan Guo, Wenqian Chen, Albert S. Song, Giovanni Aviles, Martin Kampmann, R. Luke Wiseman, Gabriel C. Lander   +10 more
openaire   +2 more sources