Results 221 to 230 of about 428,561 (236)

The integrated stress response in ischemic diseases

Cell Death & Differentiation, 2021
Ischemic disease is among the deadliest and most disabling illnesses. Prominent examples include myocardial infarction and stroke. Most, if not all, underlying pathological changes, including oxidative stress, inflammation, and nutrient deprivation, are potent inducers of the integrated stress response (ISR).
Guangyu Zhang, Xiaoding Wang, Beverly A. Rothermel, Sergio Lavandero, Zhao V. Wang   +4 more
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eIF3d controls the persistent integrated stress response

Molecular Cell, 2023
Cells respond to intrinsic and extrinsic stresses by reducing global protein synthesis and activating gene programs necessary for survival. Here, we show that the integrated stress response (ISR) is driven by the non-canonical cap-binding protein eIF3d that acts as a critical effector to control core stress response orchestrators, the translation ...
Shaoni Mukhopadhyay, Maria E. Amodeo, Amy S.Y. Lee   +2 more
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eIF4E integrates into stress response

Molecular Cell
In this issue, Diamond et al.1 and Kim et al.2 report that depletion of eIF4E leads to translational upregulation of GCN4, a key player in the integrated stress response, in an eIF2α phosphorylation-independent manner, suggesting a new mode of translational adaptation.
Xincheng, Wu, Shu-Bing, Qian
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Integrating stress responses and immunity

Science, 2019
Stress is required to assemble immune signaling complexes during ...
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Integrating the response to stressed mitochondria

Molecular Cell
Chakrabarty et al.1 demonstrate that phospho-EIF2α (pEIF2α), the translation initiation factor that mediates the integrated stress response (ISR), is necessary and sufficient for the autophagic degradation of mitochondria following the addition of mitochondrial stressors.
Elliot, Dine, Richard J, Youle
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Integrated Stress Response Couples Mitochondrial Protein Translation With Oxidative Stress Control

Circulation, 2021
Background: The integrated stress response (ISR) is an evolutionarily conserved process to cope with intracellular and extracellular disturbances. Myocardial infarction is a leading cause of death worldwide. Coronary artery reperfusion, the most effective means to mitigate cardiac damage of myocardial infarction, causes ...
Guangyu Zhang, Xiaoding Wang, Chao Li, Qinfeng Li, Yu A. An, Xiang Luo, Yingfeng Deng, Thomas G. Gillette, Philipp E. Scherer, Zhao V. Wang   +9 more
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The Unfolded Protein Response and Integrated Stress Response to Anoxia

Clinical Cancer Research, 2007
Abstract The lack of oxygen delivery to tumor cells has profound consequences for tumor growth and correlates with poor prognosis. Some tumors contain regions of very severe hypoxia called anoxia, which constitutes a functionally different state to hypoxia. In response to anoxia, mammalian cells induce coordinated cytoprotective programs
Tomasz, Rzymski, Adrian L, Harris
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Integrated Stress Response Potentiates Ponatinib-Induced Cardiotoxicity

Circulation Research
BACKGROUND: Mitochondrial dysfunction is a primary driver of cardiac contractile failure; yet, the cross talk between mitochondrial energetics and signaling regulation remains obscure. Ponatinib, a tyrosine kinase inhibitor used to treat chronic myeloid leukemia, is among the most cardiotoxic tyrosine kinase inhibitors and ...
Gege Yan, Zhenbo Han, Youjeong Kwon, Jordan Jousma, Sarath Babu Nukala, Benjamin L. Prosser, Xiaoping Du, Sandra Pinho, Sang-Bing Ong, Won Hee Lee, Sang-Ging Ong   +10 more
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Mammalian integrated stress responses in stressed organelles and their functions

Acta Pharmacologica Sinica
The integrated stress response (ISR) triggered in response to various cellular stress enables mammalian cells to effectively cope with diverse stressful conditions while maintaining their normal functions. Four kinases (PERK, PKR, GCN2, and HRI) of ISR regulate ISR signaling and intracellular protein translation via mediating the phosphorylation of ...
Hao-Jun, Lu, Nirmala, Koju, Rui, Sheng
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Integrated Responses of Plants to Stress

BioScience, 1991
In both natural and agricultural communities, the environment is seldom optimal for plant growth. Environmental stress limits the overall productivity of US agriculture to 25% of its potential (Boyer 1982). All mesic environments experience large seasonal fluctuations in light, moisture, temperature, and nutrients, often to levels that are suboptimal ...
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