Results 91 to 100 of about 154,422 (243)

Activation of Hypoxia-Inducible Factor Signaling Modulates the RNA Protein Interactome in Caenorhabditis elegans

iScience, 2019
Summary: The cellular response to hypoxia is crucial to organismal survival, and hypoxia-inducible factors (HIF) are the key mediators of this response. HIF-signaling is central to many human diseases and mediates longevity in the nematode.
Reza Esmaillie, Michael Ignarski, Katrin Bohl, Tim Krüger, Daniyal Ahmad, Lisa Seufert, Bernhard Schermer, Thomas Benzing, Roman-Ulrich Müller, Francesca Fabretti   +9 more
doaj   +1 more source

Probabilistic methods in the analysis of protein interaction networks [PDF]

, 2010
Imperial Users ...
Thorne, Thomas, Thorne, Thomas
core  

ProbCD: enrichment analysis accounting for categorization uncertainty [PDF]

, 2007
As in many other areas of science, systems biology makes extensive use of statistical association and significance estimates in contingency tables, a type of categorical data analysis known in this field as enrichment (also over-representation or ...
A Lewin, A Vinayagam, B Engelhardt, C Andersson, C Jones, D Martin, E Levy, I Rivals, Ilya Shmulevich, J Goeman, L Goodman, M Aubry, P Shannon, R Fisher, R Sealfon, R Vencio, Ricardo ZN Vêncio, S Carroll, S Maere, T Joshi, W Zhang, W Zhang, Z Jiang   +22 more
core   +5 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Injured tubular epithelia-derived CCN1 promotes the mobilization of fibroblasts toward injury sites after kidney injury

iScience
Summary: Humoral factors that prompt fibroblasts to migrate to an injury site at an appropriate time point are deemed indispensable for repair after kidney injury.
Tomohiro Nakata, Yuhei Kirita, Minato Umehara, Masashi Nakamura, Shinji Sawai, Atsushi Minamida, Hiroko Yamauchi-Sawada, Yasuto Sunahara, Yayoi Matoba, Natsuko Okuno-Ozeki, Itaru Nakamura, Kunihiro Nakai, Aya Yagi-Tomita, Noriyuki Yamashita, Keiichi Tamagaki, Benjamin D. Humphreys, Satoaki Matoba, Tetsuro Kusaba   +17 more
doaj   +1 more source

The emerging structure of the Extended Evolutionary Synthesis: where does Evo-Devo fit in? [PDF]

, 2018
The Extended Evolutionary Synthesis (EES) debate is gaining ground in contemporary evolutionary biology. In parallel, a number of philosophical standpoints have emerged in an attempt to clarify what exactly is represented by the EES.
A Fuentes, A Fábregas-Tejeda, A Minelli, A Stoltzfus, A Wagner, A Wilkins, AC Love, AC Love, AC Love, AC Love, Alejandro Fábregas-Tejeda, AP Moczek, B Grant, B Sidlauskas, BH Weber, BK Hall, CH Waddington, D Charlesworth, D Duboule, D Noble, D Noble, DJ Depew, DJ Depew, DJ Futuyma, DJ Futuyma, DJ Nicholson, DR Brooks, E Abouheif, E Danchin, E Jablonka, E Jablonka, E Mayr, E Mayr, E Pennisi, E Pennisi, EH Davidson, EI Svensson, EL Peterson, F Suman, FJ Odling-Smee, Francisco Vergara-Silva, G Caponi, G Dassow von, G Fusco, G Gottlieb, GB Müller, GB Müller, GB Müller, GB Müller, GB Müller, GD Wassermann, GP Wagner, GP Wagner, GP Wagner, GP Wagner, GP Wagner, H Palma, HE Hoekstra, I Brigandt, I Brigandt, I Brigandt, I Hacking, I Lakatos, I Tëmkin, J Jaeger, J Whitfield, JA Endler, James Griesemer, JJ Welch, JL Gaddis, JL Hendrikse, JO Reiss, JR True, JS Wicken, K Laland, K Laland, K Laland, K Raj, KE Willmore, KN Laland, L Craig, L Darden, L Nuño de la Rosa, L Nuño de la Rosa, LI Held, LR Craig, M Casanueva, M Casanueva, M Lynch, M Martínez, M Martínez, M Nei, M Pavličev, M Pavličev, M Pigliucci, M Pigliucci, M Pigliucci, M Pigliucci, M Pigliucci, M Rebeiz, MD Laubichler, MD Laubichler, MD Laubichler, MJ West-Eberhard, MW Kirschner, N Eldredge, N Eldredge, N Irie, N Shubin, P Bateson, P Feyerabend, R Amundson, R Bonduriansky, R Bonduriansky, R Diogo, RA Raff, RG Delisle, RG Delisle, RG Winther, RJ Sommer, RM Burian, S Handschuh, S Oyama, SA Newman, SA Newman, SB Carroll, SB Carroll, SF Gilbert, SH Kellert, SJ Gould, SJ Gould, SM Stanley, T Ingold, T Lewens, T Pievani, T Pievani, T Pievani, T Pradeu, U Dieckmann, U Kutschera, VB Smocovitis, W Arthur, W Arthur, W Arthur, W Callebaut   +144 more
core   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Transcriptomic characterization of lung pericytes in systemic sclerosis-associated pulmonary fibrosis

iScience
Summary: Systemic sclerosis (SSc) is a chronic disease characterized by fibrosis and vascular abnormalities in the skin and internal organs, including the lung.
Ludivine Renaud, Carole L. Wilson, Robert Lafyatis, Lynn M. Schnapp, Carol A. Feghali-Bostwick   +4 more
doaj   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source