Results 91 to 100 of about 161,935 (259)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

3D imaging and single-cell analysis reveal cellular heterogeneity of lymphatic valve endothelial cell types

iScience
Summary: Lymphatic vasculature has specialized vessels to support unidirectional interstitial fluid transport and immune surveillance. Although the lymphatic system is a critical actor in skin homeostasis, the spatial organization of the lymphatic ...
Emmanuelle Marchaud, Renaud Morin, Jason S. Iacovoni, Tangra Draia-Nicolau, Aurélie Gomes, Marine Norlund, Pascale Bernes-Lasserre, Jean-Michel Lagarde, Anne-Catherine Prats, Barbara Garmy-Susini, Anne Bouloumie, Anaïs Briot, Florence Tatin   +12 more
doaj   +1 more source

Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review [PDF]

, 2011
A variety of genome-wide profiling techniques are available to probe complementary aspects of genome structure and function. Integrative analysis of heterogeneous data sources can reveal higher-level interactions that cannot be detected based on ...
Akavia, Andrews, Baasiri, Chin, Dai, De Bie, Futreal, H.-U. Klein, Haverty, Hawkins, Hyman, Johnson, Kao, L. Lahti, M. Dugas, M. Schafer, McLendon, Menezes, Mullighan, Mullighan, Myllykangas, Olshen, Ortiz-Estevez, Phillips, Qin, S. Bicciato, Solvang, Soneson, Stranger, van Wieringen, van Wieringen   +30 more
core   +2 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Activation of Hypoxia-Inducible Factor Signaling Modulates the RNA Protein Interactome in Caenorhabditis elegans

iScience, 2019
Summary: The cellular response to hypoxia is crucial to organismal survival, and hypoxia-inducible factors (HIF) are the key mediators of this response. HIF-signaling is central to many human diseases and mediates longevity in the nematode.
Reza Esmaillie, Michael Ignarski, Katrin Bohl, Tim Krüger, Daniyal Ahmad, Lisa Seufert, Bernhard Schermer, Thomas Benzing, Roman-Ulrich Müller, Francesca Fabretti   +9 more
doaj   +1 more source

Expression systems for industrial Gram-positive bacteria with low guanine and cytosine content [PDF]

, 1997
Recent years have seen an increase in the development of gene expression systems for industrial Gram-positive bacteria with low guanine and cytosine content that belong to the genera Bacillus, Clostridium, Lactococcus, Lactobacillus, Staphylococcus and ...
Kleerebezem, Michiel,, Kuipers, Oscar P.,, Vos, Willem M. de,   +2 more
core   +2 more sources

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Probabilistic methods in the analysis of protein interaction networks [PDF]

, 2010
Imperial Users ...
Thorne, Thomas, Thorne, Thomas
core  

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Transcriptomic characterization of lung pericytes in systemic sclerosis-associated pulmonary fibrosis

iScience
Summary: Systemic sclerosis (SSc) is a chronic disease characterized by fibrosis and vascular abnormalities in the skin and internal organs, including the lung.
Ludivine Renaud, Carole L. Wilson, Robert Lafyatis, Lynn M. Schnapp, Carol A. Feghali-Bostwick   +4 more
doaj   +1 more source