Results 1 to 10 of about 227,700 (249)

Myosin-X and talin modulate integrin activity at filopodia tips

Cell Reports, 2021
Summary: Filopodia assemble unique integrin-adhesion complexes to sense the extracellular matrix. However, the mechanisms of integrin regulation in filopodia are poorly defined.
Mitro Miihkinen, Max L.B. Grönloh, Ana Popović, Helena Vihinen, Eija Jokitalo, Benjamin T. Goult, Johanna Ivaska, Guillaume Jacquemet   +7 more
doaj   +1 more source

N-glycosylation of ß4 integrin controls the adhesion and motility of keratinocytes. [PDF]

PLoS ONE, 2011
α6ß4 integrin is an essential component of hemidesmosomes and modulates cell migration in wound healing and cancer invasion. To elucidate the role of N-glycosylation on ß4 integrin, we investigated keratinocyte adhesion and migration through the re ...
Yoshinobu Kariya, Jianguo Gu
doaj   +1 more source

Peptide-Based Nanoparticles for αvβ3 Integrin-Targeted DNA Delivery to Cancer and Uterine Leiomyoma Cells

Molecules, 2022
Uterine leiomyoma is the most common benign tumor of the reproductive system. Current therapeutic options do not simultaneously meet the requirements of long-term efficiency and fertility preservation.
Anna Egorova, Alexander Selutin, Marianna Maretina, Sergei Selkov, Anton Kiselev   +4 more
doaj   +1 more source

Tubulointerstitial de novo expression of the α8 integrin chain in a rodent model of renal fibrosis--a potential target for anti-fibrotic therapy? [PDF]

PLoS ONE, 2012
In the normal kidney, the α8 integrin chain is expressed only on mesangial cells and vascular smooth muscle cells. α8 integrin ligates several matrix molecules including fibronectin, osteopontin and fibrillin-1.
Andrea Hartner, Carlos Menendez-Castro, Nada Cordasic, Ines Marek, Gudrun Volkert, Bernd Klanke, Wolfgang Rascher, Karl F Hilgers   +7 more
doaj   +1 more source

Main Factors Involved in Thyroid Hormone Action

Molecules, 2021
The thyroid hormone receptors are the mediators of a multitude of actions by the thyroid hormones in cells. Most thyroid hormone activities require interaction with nuclear receptors to bind DNA and regulate the expression of target genes. In addition to
Lorena Tedeschi, Cristina Vassalle, Giorgio Iervasi, Laura Sabatino   +3 more
doaj   +1 more source

Calreticulin Regulates β1-Integrin mRNA Stability in PC-3 Prostate Cancer Cells

Biomedicines, 2022
Prostate cancer (PCa) is the major cause of cancer-related death among aging men worldwide. Recent studies have suggested that calreticulin (CRT), a multifunctional chaperon protein, may play an important role in the regulation of PCa tumorigenesis and ...
Yueh-Chien Lin, Yuan-Li Huang, Ming-Hua Wang, Chih-Yu Chen, Wei-Min Chen, Yi-Cheng Weng, Pei-Yi Wu   +6 more
doaj   +1 more source

Mapping densely packed αIIbβ3 receptors in murine blood platelets with expansion microscopy

Platelets, 2022
Interrogating platelets and their densely packed, highly abundant receptor landscape is key to understand platelet clotting, a process that can save lives when stopping blood loss after an injury, but also kill when causing heart attack, stroke, or ...
Hannah S. Heil, Max Aigner, Sophia Maier, Prateek Gupta, Luise M.C. Evers, Vanessa Göb, Charly Kusch, Mara Meub, Bernhard Nieswandt, David Stegner, Katrin G. Heinze   +10 more
doaj   +1 more source

Adaptation of cell spreading to varying fibronectin densities and topographies is facilitated by β1 integrins

Frontiers in Bioengineering and Biotechnology, 2022
Cells mechanical behaviour in physiological environments is mediated by interactions with the extracellular matrix (ECM). In particular, cells can adapt their shape according to the availability of ECM proteins, e.g., fibronectin (FN).
Enrico Domenico Lemma, Zhongxiang Jiang, Franziska Klein, Franziska Klein, Tanja Landmann, Kai Weißenbruch, Sarah Bertels, Marc Hippler, Marc Hippler, Bernhard Wehrle-Haller, Martin Bastmeyer, Martin Bastmeyer   +11 more
doaj   +1 more source

Novel role of Dipterocarpus tuberculatus as a stimulator of focal cell adhesion through the regulation of MLC2/FAK/Akt signaling pathway

Cell Adhesion & Migration, 2022
To investigate a novel function of Dipterocarpus tuberculatus on focal cell adhesion stimulation, alterations to the regulation of focal cell adhesion-related factors were analyzed in NHDF cells and a calvarial defect rat model after treatment with ...
Su Jin Lee, Ji Eun Kim, Jae Won Jung, Yun Ju Choi, Jeong Eun Gong, Bounleuane Douangdeuane, Onevilay Souliya, Young Whan Choi, Sung Baek Seo, Dae Youn Hwang   +9 more
doaj   +1 more source

Adaptive Immunity and Pathogenesis of Diabetes: Insights Provided by the α4–Integrin Deficient NOD Mouse

Cells, 2020
Background: The spontaneously diabetic “non-obese diabetic” (NOD) mouse is a faithful model of human type-1 diabetes (T1D). Methods: Given the pivotal role of α4 integrin (CD49d) in other autoimmune diseases, we generated NOD mice with α4-deficient ...
Salim Oulghazi, Sarah K. Wegner, Gabriele Spohn, Nina Müller, Sabine Harenkamp, Albrecht Stenzinger, Thalia Papayannopoulou, Halvard Bonig   +7 more
doaj   +1 more source