Results 1 to 10 of about 304,001 (345)
Nascent Adhesion Clustering: Integrin-Integrin and Integrin-Substrate Interactions [PDF]
Biophysica, 2022 Nascent adhesions (NAs) are a general precursor to the formation of focal adhesions (FAs) that provide a fundamental mechanism for cell adhesion that is, in turn, involved in cell proliferation, migration, and mechanotransduction.
Kuanpo Lin, Robert J. Asaro
doaj +2 more sources
Biomolecules, 2023 Drug resistance is a major obstacle to successful cancer treatment. Therefore, it is essential to understand the molecular mechanisms underlying drug resistance to develop successful therapeutic strategies.
Yoshinobu Kariya +2 more
doaj +1 more source
N-glycosylation of ß4 integrin controls the adhesion and motility of keratinocytes. [PDF]
PLoS ONE, 2011 α6ß4 integrin is an essential component of hemidesmosomes and modulates cell migration in wound healing and cancer invasion. To elucidate the role of N-glycosylation on ß4 integrin, we investigated keratinocyte adhesion and migration through the re ...
Yoshinobu Kariya, Jianguo Gu
doaj +1 more source
Cell and Tissue Research, 2009 Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes. The integrin family is composed of 24 alphabeta heterodimeric members that mediate the attachment of cells to the extracellular matrix (ECM) but that also take part in specialized cell-cell interactions.
Malgorzata Barczyk +2 more
openaire +2 more sources
Genome Biology, 2007 The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. They are transmembrane alphabeta heterodimers and at least 18 alpha and eight beta subunits are known in humans, generating 24 heterodimers.
Takada, Yoshikazu +2 more
openaire +4 more sources
Journal of Cell Science, 2006 Cell adhesion, migration and the maintenance of cell polarity are all processes that depend on the correct targeting of integrins and the dynamic remodelling of integrin-containing adhesion sites. The importance of the endo/exocytic cycle of integrins as a key regulator of these functions is increasingly recognized.
Ivaska, Johanna, Pellinen, Teijo
openaire +2 more sources
β1 integrin signaling maintains human epithelial progenitor cell survival in situ and controls proliferation, apoptosis and migration of their progeny. [PDF]
PLoS ONE, 2013 β1 integrin regulates multiple epithelial cell functions by connecting cells with the extracellular matrix (ECM). While β1 integrin-mediated signaling in murine epithelial stem cells is well-studied, its role in human adult epithelial progenitor cells ...
Nancy Ernst +6 more
doaj +1 more source
Tubulointerstitial de novo expression of the α8 integrin chain in a rodent model of renal fibrosis--a potential target for anti-fibrotic therapy? [PDF]
PLoS ONE, 2012 In the normal kidney, the α8 integrin chain is expressed only on mesangial cells and vascular smooth muscle cells. α8 integrin ligates several matrix molecules including fibronectin, osteopontin and fibrillin-1.
Andrea Hartner +7 more
doaj +1 more source
Targeting of the COX-2/PGE2 axis enhances the antitumor activity of T7 peptide in vitro and in vivo
Drug Delivery, 2021 T7 peptide is considered as an antiangiogenic polypeptide. The presents study aimed to further detect the antiangiogenic mechanisms of T7 peptide and determine whether combining T7 peptide and meloxicam (COX-2/PGE2 specific inhibitor) could offer a ...
Jianrong Yang +13 more
doaj +1 more source
Immunology Today, 1989 Publisher Summary This chapter focuses on the molecular biology of the leukocyte integrins, LFA-1, Mac-1, and p150,95, and on their role in mediating inflammation. Three recent developments have underscored the importance of the leukocyte integrins as adhesion receptors of the immune system: The recognition that the leukocyte integrins are ...
Kishimoto, T +5 more
openaire +7 more sources