Results 11 to 20 of about 317,716 (343)
Cell and Tissue Research, 2009 Integrins are cell adhesion receptors that are evolutionary old and that play important roles during developmental and pathological processes. The integrin family is composed of 24 alphabeta heterodimeric members that mediate the attachment of cells to the extracellular matrix (ECM) but that also take part in specialized cell-cell interactions.
Barczyk, Malgorzata +2 more
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Nascent Adhesion Clustering: Integrin-Integrin and Integrin-Substrate Interactions [PDF]
Biophysica, 2022 Nascent adhesions (NAs) are a general precursor to the formation of focal adhesions (FAs) that provide a fundamental mechanism for cell adhesion that is, in turn, involved in cell proliferation, migration, and mechanotransduction. Nascent adhesions form when cells come into contact with substrates at all rigidities and generally involve the clustering ...
Kuanpo Lin, Robert J. Asaro
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Journal of Cell Science, 2006 Cell adhesion, migration and the maintenance of cell polarity are all processes that depend on the correct targeting of integrins and the dynamic remodelling of integrin-containing adhesion sites. The importance of the endo/exocytic cycle of integrins as a key regulator of these functions is increasingly recognized.
Ivaska, Johanna, Pellinen, Teijo
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Genome Biology, 2007 The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. They are transmembrane alphabeta heterodimers and at least 18 alpha and eight beta subunits are known in humans, generating 24 heterodimers.
Takada, Yoshikazu +2 more
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Frontiers in Cell and Developmental Biology, 2020 Angiogenesis is defined as the formation of new capillaries by sprouting from the pre-existing microvasculature. It occurs in physiological and pathological processes particularly in tumor growth and metastasis.
Alexia Vautrin-Glabik +28 more
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Biochemical Society Transactions, 2008 Agonist stimulation of integrin receptors, composed of transmembrane α and β subunits, leads cells to regulate integrin affinity (‘activation’), a process that controls cell adhesion and migration, and extracellular matrix assembly. A final step in integrin activation is the binding of talin to integrin β cytoplasmic domains.
Asoka, Banno, Mark H, Ginsberg
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Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1
Cell Communication and Signaling, 2019 Background Previously sharpin has been identified as an endogenous inhibitor of β1-integrin activation by directly binding to a conserved region in the cytoplasmic tails (CTs) of the integrin β1-associated α subunits. Methods Here we employed biochemical
Juan Gao +12 more
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Pathophysiological roles of integrins in gliomas from the perspective of glioma stem cells
Frontiers in Cell and Developmental Biology, 2022 Glioblastoma is the most common primary intracranial tumor and is also one of the most malignant central nervous system tumors. Its characteristics, such as high malignancy, abundant tumor vasculature, drug resistance, and recurrence-prone nature, cause ...
Maoyu Wang +3 more
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Integrin-mediated mechanotransduction
Journal of Cell Biology, 2016 Sun, Guo, and Fässler review the function and regulation of integrin-mediated mechanotransduction and discuss how its dysregulation impacts cancer progession.
Zhiqi Sun, Shengzhen S Guo, R. Fässler
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Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting
Journal of Hematology & Oncology, 2019 Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit bioinformation bidirectionally across the plasma membrane.
Jian-song Huang +17 more
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