Results 11 to 20 of about 227,700 (249)

Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1

Cell Communication and Signaling, 2019
Background Previously sharpin has been identified as an endogenous inhibitor of β1-integrin activation by directly binding to a conserved region in the cytoplasmic tails (CTs) of the integrin β1-associated α subunits. Methods Here we employed biochemical
Juan Gao, Yun Bao, Shushu Ge, Peisen Sun, Jiaojiao Sun, Jianmin Liu, Feng Chen, Li Han, Zhongyuan Cao, Jun Qin, Gilbert C. White, Zhen Xu, Yan-Qing Ma   +12 more
doaj   +1 more source

Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells

Cancer Biology & Therapy, 2022
The αVβ6 integrin, an epithelial-specific cell surface receptor absent in normal prostate and expressed during prostate cancer (PrCa) progression, is a therapeutic target in many cancers.
Shiv Ram Krishn, Vaughn Garcia, Nicole M. Naranjo, Fabio Quaglia, Christopher D. Shields, Maisha A. Harris, Andrew V. Kossenkov, Qin Liu, Eva Corey, Dario C. Altieri, Lucia R. Languino   +10 more
doaj   +1 more source

Win, Lose, or Tie: Mathematical Modeling of Ligand Competition at the Cell–Extracellular Matrix Interface

Frontiers in Bioengineering and Biotechnology, 2021
Integrin transmembrane proteins conduct mechanotransduction at the cell–extracellular matrix (ECM) interface. This process is central to cellular homeostasis and therefore is particularly important when designing instructive biomaterials and organoid ...
Zeynep Karagöz, Thomas Geuens, Vanessa L. S. LaPointe, Martijn van Griensven, Aurélie Carlier   +4 more
doaj   +1 more source

Deiodinase-3 is a thyrostat to regulate podocyte homeostasis

EBioMedicine, 2021
: Background: Nephrotic syndrome (NS) is associated with kidney podocyte injury and may occur as part of thyroid autoimmunity such as Graves’ disease.
Shivangi Agarwal, Kwi Hye Koh, Nicholas J. Tardi, Chuang Chen, Ranadheer Reddy Dande, Joao Pedro WerneckdeCastro, Yashwanth Reddy Sudhini, Cristina Luongo, Domenico Salvatore, Beata Samelko, Mehmet M. Altintas, Steve Mangos, Antonio Bianco, Jochen Reiser   +13 more
doaj   +1 more source

Targeting of the COX-2/PGE2 axis enhances the antitumor activity of T7 peptide in vitro and in vivo

Drug Delivery, 2021
T7 peptide is considered as an antiangiogenic polypeptide. The presents study aimed to further detect the antiangiogenic mechanisms of T7 peptide and determine whether combining T7 peptide and meloxicam (COX-2/PGE2 specific inhibitor) could offer a ...
Jianrong Yang, Jingtao Zhong, Mi Zhou, Yinghong Zhou, Peng Xiu, Feng Liu, Fuhai Wang, Zelun Li, Yuntian Tang, Yuanyuan Chen, Siyang Yao, Tao Huang, Tianqi Liu, Xiaofeng Dong   +13 more
doaj   +1 more source

Angiogenesis Inhibition by a Short 13 Amino Acid Peptide Sequence of Tetrastatin, the α4(IV) NC1 Domain of Collagen IV

Frontiers in Cell and Developmental Biology, 2020
Angiogenesis is defined as the formation of new capillaries by sprouting from the pre-existing microvasculature. It occurs in physiological and pathological processes particularly in tumor growth and metastasis.
Alexia Vautrin-Glabik, Alexia Vautrin-Glabik, Jérôme Devy, Jérôme Devy, Camille Bour, Camille Bour, Stéphanie Baud, Stéphanie Baud, Stéphanie Baud, Laurence Choulier, Anthony Hoarau, Anthony Hoarau, Aurélie Dupont-Deshorgue, Aurélie Dupont-Deshorgue, Christèle Sellier, Christèle Sellier, Bertrand Brassart, Bertrand Brassart, Jean-Baptiste Oudart, Jean-Baptiste Oudart, Jean-Baptiste Oudart, Laurent Ramont, Laurent Ramont, Laurent Ramont, Jean Claude Monboisse, Jean Claude Monboisse, Jean Claude Monboisse, Sylvie Brassart-Pasco, Sylvie Brassart-Pasco   +28 more
doaj   +1 more source

PP2A methylesterase PME‐1 suppresses anoikis and is associated with therapy relapse of PTEN‐deficient prostate cancers

Molecular Oncology, 2023
While organ‐confined prostate cancer (PCa) is mostly therapeutically manageable, metastatic progression of PCa remains an unmet clinical challenge.
Anna Aakula, Aleksi Isomursu, Christian Rupp, Andrew Erickson, Nikhil Gupta, Otto Kauko, Pragya Shah, Artur Padzik, Yuba Raj Pokharel, Amanpreet Kaur, Song‐Ping Li, Lloyd Trotman, Pekka Taimen, Antti Rannikko, Jan Lammerding, Ilkka Paatero, Tuomas Mirtti, Johanna Ivaska, Jukka Westermarck   +18 more
doaj   +1 more source

Inflammatory macrophages exploit unconventional pro-phagocytic integrins for phagocytosis and anti-tumor immunity

Cell Reports, 2021
Summary: Blockade of the inhibitory checkpoint SIRPα-CD47 promotes phagocytosis of cancer cells by macrophages and is a promising avenue in anti-cancer therapy.
Zhenghai Tang, Dominique Davidson, Rui Li, Ming-Chao Zhong, Jin Qian, Jun Chen, André Veillette   +6 more
doaj   +1 more source

Respiratory Tract Infections in Inflammatory Bowel Disease Patients Taking Vedolizumab: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Frontiers in Pharmacology, 2021
The ongoing COVID-19 pandemic has raised concerns about the risk of SARS-CoV-2 infection in patients with Crohn’s disease (CD) and patients with ulcerative colitis (UC) taking immunosuppressants or biologics.
Irene Marafini, Edoardo Troncone, Irene Rocchetti, Giovanni Monteleone   +3 more
doaj   +1 more source

Polymer Thin Film Promotes Tumor Spheroid Formation via JAK2-STAT3 Signaling Primed by Fibronectin-Integrin α5 and Sustained by LMO2-LDB1 Complex

Biomedicines, 2022
Cancer stem-like cells (CSCs) are considered promising targets for anti-cancer therapy owing to their role in tumor progression. Extensive research is, therefore, being carried out on CSCs to identify potential targets for anti-cancer therapy.
Sunyoung Seo, Nayoung Hong, Junhyuk Song, Dohyeon Kim, Yoonjung Choi, Daeyoup Lee, Sangyong Jon, Hyunggee Kim   +7 more
doaj   +1 more source