Results 251 to 260 of about 304,001 (345)

The final steps of integrin activation: the end game

Nature reviews. Molecular cell biology, 2010
S. Shattil, Chungho Kim, M. Ginsberg
semanticscholar   +1 more source

Genetic Engineering Methods in Primary T Cells

Advanced Therapeutics, EarlyView.
Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley   +1 more source

Loss of NR2F6 Protects from Salmonella Typhimurium Infection

Advanced Science, EarlyView.
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk, Christa Pfeifhofer‐Obermair, Julia Benz, Natascha Brigo, Milena Bamberger, Alexeja Kleiter, Martin Hermann, Guenter Weiss, Natascha Hermann‐Kleiter   +8 more
wiley   +1 more source

Gut-tropic α4β7⁺CD8⁺ T cells contribute to pancreatic β cell destruction in type 1 diabetes. [PDF]

Front Immunol
Su Z, Bian L, Zhao H, Cai Y, Yang T, Li S, Xu X.   +6 more
europepmc   +1 more source

Clinical significance of the integrin α6β4 in human malignancies

Laboratory Investigation, 2015
R. Stewart, K. O’Connor
semanticscholar   +1 more source

Fibronectin Fibers Progressively Lose Their Tension in Invasive Human Breast Carcinoma while Being Tensed in DCIS and Healthy Breast Tissue

Advanced Science, EarlyView.
Extracellular matrix remodeling is crucial in cancer progression. Using a peptide to probe the tension of ECM fibers, it was found that Fibronectin fibers gradually lose tension as human breast carcinoma progresses, while their tension is maintained in ductal carcinoma in situ (DCIS), the non‐invasive precursor of breast cancer. This loss of tension is
Arnaud Miéville, Charlotte M. Fonta, Cornelia Leo, Lucine Christe, Jörg Goldhahn, Gad Singer, Viola Vogel   +6 more
wiley   +1 more source

Unlocking tumor barrier: annexin A2-mediated transcytosis boosts drug delivery in pancreatic and breast tumors. [PDF]

Nat Commun
Liu Y, Wang Q, Feng Z, Qin M, Zhang Z, Jiang J, Ren T, Liu X, Jeffrey Brinker C, Zhao Y, Meng H.   +10 more
europepmc   +1 more source

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

The Serine/Threonine Kinase NDR2 Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus. [PDF]

J Neurochem
del Angel M, Tsutiya A, Hayani H, Madencioglu D, Kul E, Caliskan G, Demiray YE, Dityatev A, Stork O.   +8 more
europepmc   +1 more source

Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition.

Kidney International, 2015
Sen Shi, S. Srivastava, M. Kanasaki, Jianhua He, Munehiro Kitada, Takako Nagai, Kyoko Nitta, Susumu Takagi, K. Kanasaki, D. Koya   +9 more
semanticscholar   +1 more source