Results 251 to 260 of about 416,319 (333)

Silencing profilin-1 inhibits gastric cancer progressionviaintegrin β1/focal adhesion kinase pathway modulation

, 2015
Yajun Cheng
openalex   +2 more sources

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Integrin-Mediated TIMP1 Signaling Reprograms Liver Macrophages and Accelerates Colorectal Cancer Metastasis. [PDF]

Cells
Liu J, Zhao L, Wang L, Sheng G, Cheng P, Han M, Li G, Zheng Z.   +7 more
europepmc   +1 more source

Der Einfluss des Integrin-Rezeptor-Inhibitors Cilengitide auf die Ex-vivo-Chemoresponse von Kopf-Hals-Tumoren gegenüber Cisplatin, Docetaxel und Cetuximab im FLAVINO-Assay mit und ohne Bestrahlung

, 2014
D Schlegel
openalex   +1 more source

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source

Staphylococcal internalization into osteoblasts: a partially conserved mechanism across the genus. [PDF]

mBio
Crepin DM, Bonhomme M, Faure A, Sinel C, Bergot M, Dyon-Tafani V, Maali Y, Bouvard D, Diot A, Laurent F, Josse J.   +10 more
europepmc   +1 more source

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

Integrin-specific binding macrocyclic RGD peptides functionalized with dinitrophenol as multivalent antibody-recruiting molecules to enhance cytotoxicity in cancer immunotherapy. [PDF]

RSC Med Chem
Cheng X, Hu C, Gao W, Chen Y, Wang W, Zhu G, Wu Z.   +6 more
europepmc   +1 more source

Development of Endogenous Protein Probes for Characterizing Surface Proteins and Cellular Interactors of Extracellular Vesicles

Advanced Science, EarlyView.
The proximity labeling enzyme APEX2 is displayed on extracellular vesicle (EV) surfaces via genetic fusion with EV‐sorting scaffolds, enabling in situ biotinylation of native surface proteins, adsorbed corona components, and interacting cellular proteins.
Wenyi Zheng, Metoboroghene Mowoe, Wenqing Hou, Daniel W. Hagey, Koshi Imami, Samir EL Andaloussi   +5 more
wiley   +1 more source

The role of ADAM8 in intrahepatic cholangiocarcinoma. [PDF]

Discov Oncol
Cui X, Wang Z, Wang C, Jiang M, Song X, Liu Y, Deng X, Wang X, Zhang Y.   +8 more
europepmc   +1 more source