Results 21 to 30 of about 304,001 (345)
Integrin-mediated mechanotransduction
Journal of Cell Biology, 2016 Sun, Guo, and Fässler review the function and regulation of integrin-mediated mechanotransduction and discuss how its dysregulation impacts cancer progession.
Zhiqi Sun, Shengzhen S Guo, R. Fässler
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Journal of Cell Science, 2009 A successful immune response depends on the capacity of immune cells to travel from one location in the body to another–these cells are rapid migrators, travelling at speeds of μm/minute. Their ability to penetrate into tissues and to make contacts with other cells depends chiefly on the β2 integrin known as LFA-1.
Lena Svensson +6 more
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Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting
Journal of Hematology & Oncology, 2019 Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit bioinformation bidirectionally across the plasma membrane.
Jian-song Huang +17 more
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Prokaryotic Collagen-Like Proteins as Novel Biomaterials
Frontiers in Bioengineering and Biotechnology, 2022 Collagens are the major structural component in animal extracellular matrices and are critical signaling molecules in various cell-matrix interactions. Its unique triple helical structure is enabled by tripeptide Gly-X-Y repeats.
Jonathan Picker +6 more
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Molecular Tuning of Filamin A Activities in the Context of Adhesion and Migration
Frontiers in Cell and Developmental Biology, 2020 The dynamic organization of actin cytoskeleton meshworks relies on multiple actin-binding proteins endowed with distinct actin-remodeling activities. Filamin A is a large multi-domain scaffolding protein that cross-links actin filaments with orthogonal ...
Isabelle Lamsoul +3 more
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Integrins and the Myocardium [PDF]
Circulation Research, 2001 Abstract —Extracellular matrix provides a structural, chemical, and mechanical substrate that is essential in cardiac development, growth, and responses to pathophysiological signals. Transmembrane receptors termed integrins provide a dynamic interaction of environmental cues and intracellular events.
Robert S. Ross, Thomas K. Borg
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Structural basis of integrin regulation and signaling.
Annual Review of Immunology, 2007 Integrins are cell adhesion molecules that mediate cell-cell, cell-extracellular matrix, and cell-pathogen interactions. They play critical roles for the immune system in leukocyte trafficking and migration, immunological synapse formation, costimulation,
B. Luo, C. Carman, T. Springer
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STUDY OF THE IMMUNOLOGICAL MARKERS CD49d AND CD38 IN EARLY-STAGE B-CLL PATIENTS [PDF]
Journal of IMAB, 2018 Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of B- lymphocytes into the blood stream, primary and secondary lymphoid organs as a consequence of defect in the apoptosis. Most frequently it affects people aged 67- 72. The greater
Vanya Popova +4 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 BackgroundDevelopment of right ventricular (RV) hypertension eventually contributes to RV and left ventricular (LV) myocardial fibrosis and dysfunction. The molecular mechanisms are not fully elucidated.
Mei Sun +11 more
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Integrins and Integrin-Associated Proteins in the Cardiac Myocyte [PDF]
Circulation Research, 2014 Integrins are heterodimeric, transmembrane receptors that are expressed in all cells, including those in the heart. They participate in multiple critical cellular processes including adhesion, extracellular matrix organization, signaling, survival, and proliferation. Particularly relevant for a contracting muscle cell, integrins are mechanotransducers,
Israeli-Rosenberg, Sharon +3 more
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