Results 21 to 30 of about 416,319 (333)
The Talin Head Domain Reinforces Integrin-Mediated Adhesion by Promoting Adhesion Complex Stability and Clustering [PDF]
, 2014 Talin serves an essential function during integrin-mediated adhesion in linking integrins to actin via the intracellular adhesion complex. In addition, the N-terminal head domain of talin regulates the affinity of integrins for their ECM-ligands, a ...
Bouaouina, Mohamed +7 more
core +4 more sources
Pathophysiological roles of integrins in gliomas from the perspective of glioma stem cells
Frontiers in Cell and Developmental Biology, 2022 Glioblastoma is the most common primary intracranial tumor and is also one of the most malignant central nervous system tumors. Its characteristics, such as high malignancy, abundant tumor vasculature, drug resistance, and recurrence-prone nature, cause ...
Maoyu Wang +3 more
doaj +1 more source
Engineered microenvironments for synergistic VEGF - integrin signalling during vascularization [PDF]
, 2017 We have engineered polymer-based microenvironments that promote vasculogenesis both in vitro and in vivo through synergistic integrin-growth factor receptor signalling. Poly(ethyl acrylate) (PEA) triggers spontaneous organization of fibronectin (FN) into
Cantini, Marco +9 more
core +2 more sources
Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes [PDF]
, 2007 Adhesion molecules of the integrin beta1 family are thought to be involved in the malignant progression renal cell carcinoma (RCC). Still, it is not clear how they contribute to this process.
Achiwa H +10 more
core +1 more source
Molecular Oncology, 2023 While organ‐confined prostate cancer (PCa) is mostly therapeutically manageable, metastatic progression of PCa remains an unmet clinical challenge.
Anna Aakula +18 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2021 Integrin transmembrane proteins conduct mechanotransduction at the cell–extracellular matrix (ECM) interface. This process is central to cellular homeostasis and therefore is particularly important when designing instructive biomaterials and organoid ...
Zeynep Karagöz +4 more
doaj +1 more source
Glycosynapses: microdomains controlling carbohydrate-dependent cell adhesion and signaling
Anais da Academia Brasileira de Ciências, 2004 The concept of microdomains in plasma membranes was developed over two decades, following observation of polarity of membrane based on clustering of specific membrane components.
Senitiroh Hakomori
doaj +1 more source
Integrin‐dependent pathologies [PDF]
The Journal of Pathology, 2003 AbstractCell adhesion and migration are essential for embryonic development, tissue regeneration, and immune defence. The physical link between the extracellular substrate and the actin cytoskeleton is mediated by receptors of the integrin family and a large set of adaptor proteins.
Wehrle-Haller, Bernhard, Imhof, Beat
openaire +3 more sources
Selection and Characterization of an α6β4 Integrin blocking DNA Aptamer
Molecular Therapy: Nucleic Acids, 2016 The heterodimeric laminin receptor α6β4 integrin plays a central role in the promotion of tumor cell growth, invasion, and organotropic metastasis. As an overproduction of the integrin is often linked to a poor prognosis, the inhibition of integrin α6β4 ...
Katharina Berg +4 more
doaj +1 more source
Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection
Virulence, 2020 Leukocyte function-associated antigen 1 (LFA-1) is the most widely expressed member of the β2 integrin family of cell-cell adhesion molecules. Although LFA-1 is thought to regulate multiple aspects of T cell immunity, its role in the response of CD8+ T ...
Mario Perro +3 more
doaj +1 more source