suPAR: An Inflammatory Mediator for Kidneys
Kidney Diseases, 2022 Background: Inflammation is a common feature of many kidney diseases. The implicated inflammatory mediators and their underlying molecular mechanisms however are often not clear.
Yashwanth Reddy Sudhini +2 more
doaj +1 more source
A role for Syk-kinase in the control of the binding cycle of the β2 integrins (CD11/CD18) in human polymorphonuclear neutrophils [PDF]
, 2003 A fine control of β2 integrin (CD11/CD18)-mediated firm adhesion of human neutrophils to the endothelial cell monolayer is required to allow ordered emigration.
Arnaout +47 more
core +1 more source
Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications [PDF]
Science Signaling 12 Jan 2021: Vol. 14, Issue 665, eabd0334, 2020 The primary cell surface receptor for SARS-CoV-2 is the angiotensin-converting enzyme 2 (ACE2). Recently it has been noticed that the viral Spike protein has an RGD motif, suggesting that cell surface integrins may be co-receptors. We examined the sequences of ACE2 and integrins with the Eukaryotic Linear Motif resource, ELM, and were presented with ...
arxiv +1 more source
Integrins in Mechanotransduction [PDF]
Journal of Biological Chemistry, 2004 Mechanical forces are crucial to the regulation of cell and tissue morphology and function. At the cellular level, forces influence cytoskeletal organization, gene expression, proliferation, and survival. Integrin-mediated adhesions are intrinsically mechanosensitive and a large body of data implicates integrins in sensing mechanical forces.
Eleni Tzima +3 more
openaire +3 more sources
Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development. [PDF]
, 2018 Integrin activation regulates adhesion, extracellular matrix assembly, and cell migration, thereby playing an indispensable role in development and in many pathological processes.
Fan, Zhichao +5 more
core +2 more sources
Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability. [PDF]
, 2019 Thrombospondins (Thbs) are a family of five secreted matricellular glycoproteins in vertebrates that broadly affect cell-matrix interaction. While Thbs4 is known to protect striated muscle from disease by enhancing sarcolemmal stability through increased
Brody, Matthew J +11 more
core +3 more sources
IPP Complex Reinforces Adhesion by Relaying Tension-Dependent Signals to Inhibit Integrin Turnover
Cell Reports, 2016 Cytoskeleton-mediated forces regulate the assembly and function of integrin adhesions; however, the underlying mechanisms remain unclear. The tripartite IPP complex, comprising ILK, Parvin, and PINCH, mediates the integrin-actin link at Drosophila embryo
Katerina M. Vakaloglou +2 more
doaj +1 more source
Myosin-X and talin modulate integrin activity at filopodia tips
Cell Reports, 2021 Summary: Filopodia assemble unique integrin-adhesion complexes to sense the extracellular matrix. However, the mechanisms of integrin regulation in filopodia are poorly defined.
Mitro Miihkinen +7 more
doaj
Molecular dynamics simulations of cRGD-conjugated PEGylated TiO$_2$ nanoparticles for targeted photodynamic therapy [PDF]
, 2022 The conjugation of high-affinity cRGD-containing peptides is a promising approach in nanomedicine to efficiently reduce off-targeting effects and enhance the cellular uptake by integrin-overexpressing tumor cells. Herein we utilize atomistic molecular dynamics simulations to evaluate key structural-functional parameters of these targeting ligands for ...
arxiv +1 more source
Engineered microenvironments for synergistic VEGF - integrin signalling during vascularization [PDF]
, 2017 We have engineered polymer-based microenvironments that promote vasculogenesis both in vitro and in vivo through synergistic integrin-growth factor receptor signalling. Poly(ethyl acrylate) (PEA) triggers spontaneous organization of fibronectin (FN) into
Cantini, Marco +9 more
core +2 more sources