Results 21 to 30 of about 317,716 (343)
Molecular Oncology, 2023 While organ‐confined prostate cancer (PCa) is mostly therapeutically manageable, metastatic progression of PCa remains an unmet clinical challenge.
Anna Aakula +18 more
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Frontiers in Bioengineering and Biotechnology, 2021 Integrin transmembrane proteins conduct mechanotransduction at the cell–extracellular matrix (ECM) interface. This process is central to cellular homeostasis and therefore is particularly important when designing instructive biomaterials and organoid ...
Zeynep Karagöz +4 more
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BMB Reports, 2014 Integrin-mediated cell adhesion is important for development, immune responses, hemostasis and wound healing. Integrins also function as signal transducing receptors that can control intracellular pathways that regulate cell survival, proliferation, and cell fate.
openaire +4 more sources
Glycosynapses: microdomains controlling carbohydrate-dependent cell adhesion and signaling
Anais da Academia Brasileira de Ciências, 2004 The concept of microdomains in plasma membranes was developed over two decades, following observation of polarity of membrane based on clustering of specific membrane components.
Senitiroh Hakomori
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Integrin‐dependent pathologies [PDF]
The Journal of Pathology, 2003 AbstractCell adhesion and migration are essential for embryonic development, tissue regeneration, and immune defence. The physical link between the extracellular substrate and the actin cytoskeleton is mediated by receptors of the integrin family and a large set of adaptor proteins.
Wehrle-Haller, Bernhard, Imhof, Beat
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Selection and Characterization of an α6β4 Integrin blocking DNA Aptamer
Molecular Therapy: Nucleic Acids, 2016 The heterodimeric laminin receptor α6β4 integrin plays a central role in the promotion of tumor cell growth, invasion, and organotropic metastasis. As an overproduction of the integrin is often linked to a poor prognosis, the inhibition of integrin α6β4 ...
Katharina Berg +4 more
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Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection
Virulence, 2020 Leukocyte function-associated antigen 1 (LFA-1) is the most widely expressed member of the β2 integrin family of cell-cell adhesion molecules. Although LFA-1 is thought to regulate multiple aspects of T cell immunity, its role in the response of CD8+ T ...
Mario Perro +3 more
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Frontiers in Immunology, 2018 Integrin α5β1 is a crucial adhesion molecule that mediates the adherence of many cell types to the extracellular matrix through recognition of its classic ligand fibronectin as well as to other cells through binding to an alternative counter-receptor ...
Yesenia Machado-Pineda +16 more
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CD11b Signaling Prevents Chondrocyte Mineralization and Attenuates the Severity of Osteoarthritis
Frontiers in Cell and Developmental Biology, 2020 Osteoarthritis (OA) is a progressive joint disease that is strongly associated with calcium-containing crystal formation (mineralization) by chondrocytes leading ultimately to cartilage calcification.
Driss Ehirchiou +8 more
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Prokaryotic Collagen-Like Proteins as Novel Biomaterials
Frontiers in Bioengineering and Biotechnology, 2022 Collagens are the major structural component in animal extracellular matrices and are critical signaling molecules in various cell-matrix interactions. Its unique triple helical structure is enabled by tripeptide Gly-X-Y repeats.
Jonathan Picker +6 more
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