Results 31 to 40 of about 317,716 (343)

Interleukin-8 promotes integrin β3 upregulation and cell invasion through PI3K/Akt pathway in hepatocellular carcinoma

Journal of experimental & clinical cancer research : CR, 2019
Interleukin-8 (IL-8) plays a vital role in the invasion and metastasis of hepatocellular carcinoma (HCC), and is closely associated with poor prognosis of HCC patients. Integrin αvβ3, a member of the integrin family, has been reported to be overexpressed
Fengkai Sun, Jianping Wang, Qi Sun, Fanni Li, Heng-rui Gao, Lin Xu, Jiao Zhang, Xiaoyan Sun, Yanan Tian, Qiujie Zhao, Huimin Shen, Kai Zhang, Jun Liu   +12 more
semanticscholar   +1 more source

Integrins, cancer and snake toxins (mini-review)

Journal of Venomous Animals and Toxins including Tropical Diseases, 2005
Integrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM).
G. Rádis-Baptista
doaj   +1 more source

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

Journal of Cell Biology, 1997
In a recently developed human breast cancer model, treatment of tumor cells in a 3-dimensional culture with inhibitory β1-integrin antibody or its Fab fragments led to a striking morphological and functional reversion to a normal phenotype. A stimulatory
V. Weaver, O. Petersen, Fei Wang, C. Larabell, Per Briand, C. Damsky, M. Bissell   +6 more
semanticscholar   +1 more source

Integrin activation [PDF]

Journal of Cell Science, 2004
The ability of cells to regulate dynamically their adhesion to one another and to the extracellular matrix (ECM) that surrounds them is essential in multicellular organisms. The integrin family of transmembrane adhesion receptors mediates both cell-cell and cell-ECM adhesion.
openaire   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Integrins and p53 pathways in glioblastoma resistance to temozolomide

Frontiers in Oncology, 2012
Glioblastoma is the most common malignant primary brain tumor. Surgical resection, postoperative radiotherapy plus concomitant and adjuvant chemotherapy with temozolomide is the standard of care for newly diagnosed glioblastoma.
Monique eDontenwill, Sophie eMartin, Hana eJanouskova   +2 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6

Advanced Science
Inside‐out and outside‐in activations of integrin both play important roles in adhesion formation and cell motility. While such mechanisms of RGD‐binding integrin, including integrin β1 and β3, are well documented, mechanosensitive regulations of ...
Wan Ning Lee, Jiamin Li, Nan‐Peng Chen, Cheng‐han Yu   +3 more
doaj   +1 more source

Periostin-integrin signaling in hepatocellular carcinoma: from biological function to clinical application

Frontiers in Cell and Developmental Biology
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide and the most common primary tumor. Periostin (POSTN) is located in the extracellular matrix (ECM) and triggers tumor growth signals by binding to integrin receptors.
Jun Lei, Yong Liu, Shuai Yuan, Xiaxia Yuan, Qi Yuan   +4 more
doaj   +1 more source

The Role of the Extracellular Matrix in Cancer Stemness

Frontiers in Cell and Developmental Biology, 2019
As our understanding of cancer cell biology progresses, it has become clear that tumors are a heterogenous mixture of different cell populations, some of which contain so called “cancer stem cells” (CSCs).
Sameera Nallanthighal, James Patrick Heiserman, Dong-Joo Cheon   +2 more
doaj   +1 more source