Results 31 to 40 of about 304,001 (345)
Frontiers in Cell and Developmental Biology, 2020 Angiogenesis is defined as the formation of new capillaries by sprouting from the pre-existing microvasculature. It occurs in physiological and pathological processes particularly in tumor growth and metastasis.
Alexia Vautrin-Glabik +28 more
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Frontiers in Immunology, 2018 Integrin α5β1 is a crucial adhesion molecule that mediates the adherence of many cell types to the extracellular matrix through recognition of its classic ligand fibronectin as well as to other cells through binding to an alternative counter-receptor ...
Yesenia Machado-Pineda +16 more
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Frontiers in Bioengineering and Biotechnology, 2021 Integrin transmembrane proteins conduct mechanotransduction at the cell–extracellular matrix (ECM) interface. This process is central to cellular homeostasis and therefore is particularly important when designing instructive biomaterials and organoid ...
Zeynep Karagöz +4 more
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Cell Reports, 2021 Summary: Blockade of the inhibitory checkpoint SIRPα-CD47 promotes phagocytosis of cancer cells by macrophages and is a promising avenue in anti-cancer therapy.
Zhenghai Tang +6 more
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Perspectives of Phage–Eukaryotic Cell Interactions to Control Epstein–Barr Virus Infections
Frontiers in Microbiology, 2018 Recently, leading medical journals emphasized the importance of further studies on the potential application of bacterial viruses (phages) for the treatment of antibiotics-resistant infections outlining the present status of the therapy and perspectives ...
Andrzej Górski +10 more
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Frontiers in Pharmacology, 2021 The ongoing COVID-19 pandemic has raised concerns about the risk of SARS-CoV-2 infection in patients with Crohn’s disease (CD) and patients with ulcerative colitis (UC) taking immunosuppressants or biologics.
Irene Marafini +3 more
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Integrins and metastasis [PDF]
Cell Adhesion & Migration, 2013 Metastasis is a combination of biological events that makes the difference between cancer and other diseases. Metastasis requires flow of erroneous but precisely coordinated basic cellular activities like cell migration-invasion, cell survival-apoptosis, cell proliferation, etc. All of these processes require efficient regulation of cell attachment and
Shuvojit Moulik +3 more
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Breaking In: Human Metapneumovirus Fusion and Entry
Viruses, 2013 Human metapneumovirus (HMPV) is a leading cause of respiratory infection that causes upper airway and severe lower respiratory tract infections. HMPV infection is initiated by viral surface glycoproteins that attach to cellular receptors and mediate ...
John V. Williams, Reagan G. Cox
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The biomechanical integrin [PDF]
Journal of Biomechanics, 2010 The integrin lies at the center of our efforts to understand mechanotransduction in the human body. Over the past two decades, a wealth of information has yielded important insights into integrin structure and functioning in biochemical pathways; however, relatively little emphasis has been placed on mechanics.
Muhammad H. Zaman, Erin L. Baker
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Selection and Characterization of an α6β4 Integrin blocking DNA Aptamer
Molecular Therapy: Nucleic Acids, 2016 The heterodimeric laminin receptor α6β4 integrin plays a central role in the promotion of tumor cell growth, invasion, and organotropic metastasis. As an overproduction of the integrin is often linked to a poor prognosis, the inhibition of integrin α6β4 ...
Katharina Berg +4 more
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