Results 41 to 50 of about 304,001 (345)

Myeloid Poldip2 Contributes to the Development of Pulmonary Inflammation by Regulating Neutrophil Adhesion in a Murine Model of Acute Respiratory Distress Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Lung injury, a severe adverse outcome of lipopolysaccharide‐induced acute respiratory distress syndrome, is attributed to excessive neutrophil recruitment and effector response.
Ziwei Ou, Elena Dolmatova, Rohan Mandavilli, Hongyan Qu, Georgette Gafford, Taylor White, Alejandra Valdivia, Bernard Lassègue, Marina S. Hernandes, Kathy K. Griendling   +9 more
doaj   +1 more source

Integrin αIIbβ3 outside-in signaling.

Blood, 2017
Integrin αIIbβ3 is a highly abundant heterodimeric platelet receptor that can transmit information bidirectionally across the plasma membrane, and plays a critical role in hemostasis and thrombosis. Upon platelet activation, inside-out signaling pathways
T. N. Durrant, Marion T. J. van den Bosch, I. Hers   +2 more
semanticscholar   +1 more source

Reciprocal discoidin domain receptor signaling strengthens integrin adhesion to connect adjacent tissues

eLife, 2023
Separate tissues connect through adjoining basement membranes to carry out molecular barrier, exchange, and organ support functions. Cell adhesion at these connections must be robust and balanced to withstand independent tissue movement.
Kieop Park, Ranjay Jayadev, Sara G Payne, Isabel W Kenny-Ganzert, Qiuyi Chi, Daniel S Costa, William Ramos-Lewis, Siddharthan B Thendral, David R Sherwood   +8 more
doaj   +1 more source

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

Nature Cell Biology, 2015
Integrin receptor activation initiates the formation of integrin adhesion complexes (IACs) at the cell membrane that transduce adhesion-dependent signals to control a multitude of cellular functions.
Edward R. Horton, Adam Byron, J. Askari, Daniel H. J. Ng, Angélique Millon‐Frémillon, Joseph Robertson, E. Koper, Nikki R Paul, Stacey Warwood, David Knight, J. Humphries, M. Humphries   +11 more
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Cas phosphorylation regulates focal adhesion assembly

eLife, 2023
Integrin-mediated cell attachment rapidly induces tyrosine kinase signaling. Despite years of research, the role of this signaling in integrin activation and focal adhesion assembly is unclear.
Saurav Kumar, Amanda Stainer, Julien Dubrulle, Christopher Simpkins, Jonathan A Cooper   +4 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Integrins and integrin-related proteins in cardiac fibrosis [PDF]

Journal of Molecular and Cellular Cardiology, 2016
Cardiac fibrosis is one of the major components of the healing mechanism following any injury of the heart and as such may contribute to both systolic and diastolic dysfunction in a range of pathophysiologic conditions. Canonically, it can occur as part of the remodeling process that occurs following myocardial infarction or that follows as a response ...
Chao Chen, Chao Chen, Robert S. Ross, Robert S. Ross, Ruixia Li, Ruixia Li, Ana Maria Manso, Ana Maria Manso   +7 more
openaire   +5 more sources

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

Journal of Cell Biology, 1997
In a recently developed human breast cancer model, treatment of tumor cells in a 3-dimensional culture with inhibitory β1-integrin antibody or its Fab fragments led to a striking morphological and functional reversion to a normal phenotype. A stimulatory
V. Weaver, O. Petersen, Fei Wang, C. Larabell, Per Briand, C. Damsky, M. Bissell   +6 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source