Results 41 to 50 of about 388,340 (363)
Frontiers in Immunology, 2019 Beta2-integrins are complex leukocyte-specific adhesion molecules that are essential for leukocyte (e.g., neutrophil, lymphocyte) trafficking, as well as for other immunological processes such as neutrophil phagocytosis and ROS production, and T cell ...
Susanna C. Fagerholm +4 more
doaj +1 more source
Integrins and Integrin-Associated Proteins in the Cardiac Myocyte [PDF]
Circulation Research, 2014 Integrins are heterodimeric, transmembrane receptors that are expressed in all cells, including those in the heart. They participate in multiple critical cellular processes including adhesion, extracellular matrix organization, signaling, survival, and proliferation. Particularly relevant for a contracting muscle cell, integrins are mechanotransducers,
Israeli-Rosenberg, Sharon +3 more
openaire +5 more sources
Recreation of the terminal events in physiological integrin activation. [PDF]
, 2010 Increased affinity of integrins for the extracellular matrix (activation) regulates cell adhesion and migration, extracellular matrix assembly, and mechanotransduction.
Bobkov, Andrey A +8 more
core +3 more sources
CD11b Signaling Prevents Chondrocyte Mineralization and Attenuates the Severity of Osteoarthritis
Frontiers in Cell and Developmental Biology, 2020 Osteoarthritis (OA) is a progressive joint disease that is strongly associated with calcium-containing crystal formation (mineralization) by chondrocytes leading ultimately to cartilage calcification.
Driss Ehirchiou +8 more
doaj +1 more source
Paramagnetic response of muscle-type systems [PDF]
Phys. Rev. E 93, 062407 (2016), 2015 We provide a prototypical description of mechanically-induced collective conformational change (folding), relevant in a variety of biological contexts from muscle contraction to hair cell gating and integrin binding. Our study is inspired by the seminal Huxley-Simmons (HS) model which we reinterpret from the perspective of stochastic dynamics involving
arxiv +2 more sources
Integrin α2β1 in nonactivated conformation can induce focal adhesion kinase signaling. [PDF]
, 2017 Conformational activation of integrins is generally required for ligand binding and cellular signalling. However, we have previously reported that the nonactivated conformation of α2β1 integrin can also bind to large ligands, such as human echovirus 1 ...
Cheng, R Holland +5 more
core +2 more sources
Integrin activation - the importance of a positive feedback [PDF]
, 2005 Integrins mediate cell adhesion and are essential receptors for the development and functioning of multicellular organisms. Integrin activation is known to require both ligand and talin binding and to correlate with cluster formation but the activation mechanism and precise roles of these processes are not yet resolved. Here mathematical modeling, with
arxiv +1 more source
Clustering of lipids driven by integrin [PDF]
arXiv, 2022 Integrin is an important transmembrane receptor protein which remodels the actin network and anchors the cell membrane towards the extracellular matrix via mechanochemical pathways. The clustering of specific lipids and lipid-anchored proteins, which is essential for a certain type of endocytosis process, is facilitated at integrin-mediated active ...
arxiv
Integrins and metastasis [PDF]
Cell Adhesion & Migration, 2013 Metastasis is a combination of biological events that makes the difference between cancer and other diseases. Metastasis requires flow of erroneous but precisely coordinated basic cellular activities like cell migration-invasion, cell survival-apoptosis, cell proliferation, etc. All of these processes require efficient regulation of cell attachment and
Shuvojit Moulik +3 more
openaire +2 more sources
The biomechanical integrin [PDF]
Journal of Biomechanics, 2010 The integrin lies at the center of our efforts to understand mechanotransduction in the human body. Over the past two decades, a wealth of information has yielded important insights into integrin structure and functioning in biochemical pathways; however, relatively little emphasis has been placed on mechanics.
Muhammad H. Zaman, Erin L. Baker
openaire +2 more sources