Results 41 to 50 of about 317,716 (343)

Regulatory Mechanism of ITGBL1 in the Metastasis of Colorectal Cancer

Frontiers in Oncology, 2020
Integrin, beta-like 1 (ITGBL1) protein is located in the extracellular matrix (ECM) and involved in the development and metastasis of many tumors. However, the regulatory mechanism of ITGBL1 in colorectal cancer (CRC) remains unclear.
Lu Qi, Lu Qi, Lu Qi, Fuyao Song, Fuyao Song, Fuyao Song, Yanqing Ding, Yanqing Ding, Yanqing Ding   +8 more
doaj   +1 more source

Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability

Nature Materials, 2017
Integrin binding to bioengineered hydrogel scaffolds is essential for tissue regrowth and regeneration, yet not all integrin binding can lead to tissue repair. Here, we show that through engineering hydrogel materials to promote α3/α5β1 integrin binding,
Shuoran Li, Lina Nih, Haylee N. Bachman, Peng Fei, Peng Fei, Yilei Li, E. Nam, R. Dimatteo, S. Carmichael, T. Barker, T. Segura   +10 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Hydrogels Derivatized With Cationic Moieties or Functional Peptides as Efficient Supports for Neural Stem Cells

Frontiers in Neuroscience, 2020
The increasing incidence of neurodegenerative diseases such as Alzheimer’s or Parkinson’s disease represents a significant burden for patients and national health systems.
Kristin Glotzbach, Nils Stamm, Ralf Weberskirch, Andreas Faissner   +3 more
doaj   +1 more source

Mechanotransduction of matrix stiffness in regulation of focal adhesion size and number: reciprocal regulation of caveolin-1 and β1 integrin

Scientific Reports, 2017
Focal adhesion (FA) assembly, mediated by integrin activation, responds to matrix stiffness; however, the underlying mechanisms are unclear. Here, we showed that β1 integrin and caveolin-1 (Cav1) levels were decreased with declining matrix stiffness ...
Yi-Chun Yeh, Jinjing Ling, Wan-chun Chen, Hsi-Hui Lin, M. Tang   +4 more
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Experimental Right Ventricular Hypertension Induces Regional β1‐Integrin–Mediated Transduction of Hypertrophic and Profibrotic Right and Left Ventricular Signaling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundDevelopment of right ventricular (RV) hypertension eventually contributes to RV and left ventricular (LV) myocardial fibrosis and dysfunction. The molecular mechanisms are not fully elucidated.
Mei Sun, Ryo Ishii, Kenichi Okumura, Adrienn Krauszman, Siegfried Breitling, Olga Gomez, Aleksander Hinek, Stellar Boo, Boris Hinz, Kim A. Connelly, Wolfgang M. Kuebler, Mark K. Friedberg   +11 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Evaluation of Integrin Glycovariants as Biomarkers of Metastasis, Invasion, and Therapy Stratification in Head and Neck Squamous Cell Carcinoma

Cancer Medicine
Background Integrin glycosylation is one mechanism regulating the invasion and metastasis of malignant tumors. Little information exists about integrin glycosylation in head and neck squamous cell carcinoma (HNSCC).
Erica Routila, Sadie Salminen, Randa Mahran, Mervi Toriseva, Heikki Irjala, Eeva Haapio, Eero Kytö, Sami Ventelä, Kim Pettersson, Johannes Routila, Kamlesh Gidwani, Janne Leivo   +11 more
doaj   +1 more source