Results 101 to 110 of about 62,112 (126)

Ectopic αIIbβ3 Integrin Signaling Involves 12-Lipoxygenaseand PKC-mediated Serine Phosphorylation Events in Melanoma Cells

, 2001
SummaryMegakaryocytic genes such as αIIbβ3 can be expressed by malignant cells as part of the disturbances in their gene regulation. However, the function of the gene product greatly depends on the interaction of the ectopic protein with the new ...
Sándor Paku, József Tóvári, Mohit Trikha, Erzsébet Rásó, Krisztina Tóth, Kenneth Honn, József Tímár   +6 more
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Autocrine amplification of integrin αIIbβ3 activation and platelet adhesive responses by deoxyribose-1-phosphate

, 2013
Using direct injection mass spectrometry (DIMS) we discovered that deoxyribose-1-phosphate (dRP) is released by platelets upon activation. Interestingly, the addition of exogenous dRP to human platelets significantly increased platelet aggregation and ...
Hirano, M, Vara D. S., Canobbio, I, Dunn, W B, Pula, G, Pula, Giordano, Vara, Dina S, Dunn, Warwick B., Campanella, Michelangelo, Pizzorno, G, Canobbio, Ilaria, Hirano M., Vara, D S, Pizzorno, Giuseppe, Vara, Dina S., Campanella, M, Pizzorno G., Pula G., Dunn W. B., Dunn, Warwick B, Campanella M., Hirano, Michio   +21 more
core   +1 more source

Transmembrane thiol isomerase TMX1 inhibits fibrin formation by down-regulation of platelet phosphatidylserine exposure

Cell Communication and Signaling
Objective Membrane exposure of phosphatidylserine (PS) on platelets is critical for the binding of coagulation factors leading to coagulation activation, however, the mechanism controlling PS exposure remains largely unknown.
Zhenzhen Zhao, Yaqiong Zhang, Yixin Cheng, Xuyang Chen, Yi Lu, Yue Han, Yi Wu, Aizhen Yang   +7 more
doaj   +1 more source

Strong Binding of Platelet Integrin αiIbβ3 to Fibrin Clots: Potential Target to Destabilize Thrombi

, 2020
© 2017 The Author(s). The formation of platelet thrombi is determined by the integrin αIIbβ3-mediated interactions of platelets with fibrinogen and fibrin.
Weisel J., Xu S., Kim O., Litvinov R., Alber M., Xu Z., Bennett J., Höök P.   +7 more
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Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science
Cardiovascular and cerebrovascular diseases, the leading causes of death worldwide, are primarily driven by pathological thrombus formation resulting from uncontrolled platelet aggregation at sites of atherosclerotic plaque rupture.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
doaj   +1 more source

PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signaling and platelet function through up-regulation of protein kinase A activity.

, 2017
Essentials peroxisome proliferator-activated receptor γ (PPARγ) agonists inhibit platelet function. PPARγ agonists negatively regulate outside-in signaling via integrin αIIbβ3. PPARγ agonists disrupt the interaction of Gα13 with integrin β3.
Amanda Unsworth (23881242), JM Gibbins (17179684), AP Bye (24010362), K Naran (24054453), N Kriek (19157284), T Sage (24054456), GD Flora (24054459)   +6 more
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Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions

Nature Reviews Molecular Cell Biology, 2022
Pakorn Kanchanawong, David A Calderwood
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The final steps of integrin activation: the end game

Nature Reviews Molecular Cell Biology, 2010
Mark H Ginsberg, Sanford J Shattil, Chungho Kim   +2 more
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Integrins as biomechanical sensors of the microenvironment

Nature Reviews Molecular Cell Biology, 2019
Pere Roca-cusachs, Jenny Z Kechagia, Johanna Ivaska   +2 more
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The integrin adhesome: from genes and proteins to human disease

Nature Reviews Molecular Cell Biology, 2014
Benjamin Geiger, Reinhard Fässler, Kyle R. Legate   +2 more
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