Results 81 to 90 of about 62,112 (126)
The Platelet Integrin αIIbβ3 Binds to the RGD and AGD Motifs in Fibrinogen
, 2009 SummaryFibrinogen (Fbg) mediates platelet aggregation by binding the αIIbβ3 integrin receptor, but the interaction of the receptor with peptide motifs of Fbg remains unresolved.
Sánchez-Cortés, Juan, Mrksich, Milan
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A Disease Mechanism Underlying Bleeding in Wiskott-Aldrich Syndrome
Clinical Medicine Insights: Blood Disorders, 2008 The Wiskott-Aldrich Syndrome (WAS) is an × chromosome-linked immunodeficiency disorder. The most common symptom in WAS is bleeding. Several clinical investigations indicate that low platelet counts and defective platelet aggregation are the major causes ...
Shigeru Tsuboi
doaj +1 more source
Design und Synthese Neuartiger αIIbβ3 Integrin Antagonisten
, 2013 Inhibition of integrin function is a major challenge in medicinal chemistry. The carboxylic acid group in integrin ligands is the most conserved functionality since it is essential for the coordination of the bivalent metal cation at the metal-ion ...
Bollinger, Markus
core
Kindlin-3 phosphorylation is crucial for thrombosis and hemostasis in vivo
Research and Practice in Thrombosis and HaemostasisBackground: A single phosphorylation in kindlin-3 at S484 (human) or S485 (mouse) has been shown to regulate its function in a variety of cells in vitro.
Elzbieta Pluskota +6 more
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Effect of Lysosomotropic Polyamineoxidase Inhibitor MDL-72527 on Platelet Activation
Cellular Physiology and Biochemistry, 2016 Background/Aims: The polyamine oxidase inhibitor MDL-72527 (N1,N4-bis(2,3-butadienyl)-1,4-butanediamine) were expected to increase the abundance of spermine, a powerful inhibitor of platelet activation.
Guoxing Liu +7 more
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Characterization of a protein: protein interaction between RNF181 and the platelet integrin, αIIbβ3
, 2015 The integrin αIIbβ3 is a heterodimeric protein that exists in an inactive, resting state within the membrane of quiescent platelets. In response to platelet activation within a pro-thrombotic environment, the integrin αIIbβ3 becomes active, serves as a ...
Seamus Allen (384024)
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Primary Megakaryocytes Reveal a Role for Transcription Factor Nf-E2 in Integrin αiibβ3 Signaling [PDF]
, 1999 Platelet integrin αIIbβ3 responds to intracellular signals by binding fibrinogen and triggering cytoskeletal reorganization, but the mechanisms of αIIbβ3 signaling remain poorly understood.
Sanford Shattil +19 more
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BiomoleculesGalectin-3 (Gal3) is one of the most pro-inflammatory proteins and a biomarker of inflammatory diseases and cancer. Previous studies showed that Gal3 binds to αv and β1 integrins, but it is unclear how Gal3 binds to integrins.
Yoko K. Takada +2 more
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Cellular Physiology and Biochemistry, 2017 Background/Aims: The mammalian target of rapamycin (mTOR) inhibitor temsirolimus stimulates apoptosis of tumor cells and is thus therapeutically used for the treatment of diverse malignancies.
Hang Cao +4 more
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Multiple domains of human PSG1 bind the platelet integrin αIIbβ3.
, 2013 a, Integrin αIIbβ3 (2µg purified protein; lanes 1–3) pulls down PSG1 in an in vitro binding assay (lane 1). Negative controls are Protein G agarose beads with (lane 2) and without (lane 4) αIIbβ3, and with rabbit IgG instead of PSG1 (lane 3).
Melanie Ball (384026) +11 more
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