Results 61 to 70 of about 62,112 (126)

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

The enigmatic nature of the triggering receptor expressed in myeloid cells -1 (TLT- 1)

Platelets, 2021
Receptors are important pharmacological targets on cells. The Triggering Receptor Expressed on Myeloid Cells (TREM) – Like Transcript – 1 is an abundant, yet little understood, platelet receptor.
Siobhan Branfield, A. Valance Washington
doaj   +1 more source

From haemostasis to immunity: The expanding frontiers of platelet biology

British Journal of Haematology, Volume 209, Issue 4, Page 1482-1485, October 2026.
Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley   +1 more source

The importance of N-glycosylation on β3 integrin ligand binding and conformational regulation

Scientific Reports, 2017
N-glycosylations can regulate the adhesive function of integrins. Great variations in both the number and distribution of N-glycosylation sites are found in the 18 α and 8 β integrin subunits.
Xiulei Cai, Aye Myat Myat Thinn, Zhengli Wang, Hu Shan, Jieqing Zhu   +4 more
doaj   +1 more source

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, Volume 4, Issue 3, September 2026.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Integrin αIIbβ3 outside-in signaling activates human platelets through serine 24 phosphorylation of Disabled-2

Cell & Bioscience, 2021
Background Bidirectional integrin αIIbβ3 signaling is essential for platelet activation. The platelet adaptor protein Disabled-2 (Dab2) is a key regulator of integrin signaling and is phosphorylated at serine 24 in eukaryotic cells.
Hui-Ju Tsai, Ju-Chien Cheng, Man-Leng Kao, Hung-Pin Chiu, Yi-Hsuan Chiang, Ding-Ping Chen, Kun-Ming Rau, Hsiang-Ruei Liao, Ching-Ping Tseng   +8 more
doaj   +1 more source

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3)-binder Rasa3 Regulates Phosphoinositide 3-kinase (PI 3-kinase)-dependent Integrin αIIbβ3 Outside-in Signaling [PDF]

, 2017
The class I phosphoinositide 3-kinase (PI 3-kinase) family of lipid kinases plays an important role in integrin αIIbβ3 function, thereby supporting thrombus growth and consolidation.
Battram, Anthony M., Paul, David S., Piatt, Raymond, Heesom, Kate, Durrant, Tom N., Hers, Ingeborg, Battram, Anthony, Agbani, Ejaife, Moore, Samantha, Poole, Alastair, Cullen, Pete, Bergmeier, Wolfgang, Heesom, Kate J., Durrant, Tom, Poole, Alastair W., Moore, Samantha F., Cullen, Peter J., Agbani, Ejaife O.   +17 more
core   +1 more source

Current strategies to enhance the target efficiency of advanced multifunctional ultrasound contrast agents in ischemic diseases

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
The graphical abstract outlines a novel multifunctional ultrasound contrast agent for the diagnosis and treatment of ischemic diseases, along with innovative strategies to enhance its targeting efficiency. Abstract Ischemic diseases, such as myocardial infarction, stroke, and peripheral ischemia, are leading causes of death and disability worldwide ...
Yangyang Zhou, Jing Lin, Yu Chen, Jiaqi Zhao   +3 more
wiley   +1 more source

Integrin αIIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta

Biology Open, 2013
Summary Integrins are transmembrane receptors that play important roles as modulators of cell behaviour through their adhesion properties and the initiation of signaling cascades.
Jean-Charles Boisset, Thomas Clapes, Reinier Van Der Linden, Elaine Dzierzak, Catherine Robin   +4 more
doaj   +1 more source

High-resolution cryo-EM structure of integrin αIIbβ3 bound to disease-causing maternal HPA-1a antibody that blocks integrin activation

Integrins promote immunity, embryonic development, wound healing, and hemostasis, and are activated by ‘bent/closed’ to ‘extended/open’ conformational changes.
Ellen van der Schoot, Junichi Takagi, Marcos Gragera, Wendy Stam, Femke van der Meer, Eleftherios Zarkadas, José M. de Pereda, Francisco J. Chichón, Gestur Vidarsson, Coert Margadant, Gragera, Marcos, van der Meer, Femke, Chichón, Francisco Javier, Zarkadas, Eleftherios, Margadant, Coert, Stam, Wendy, van der Schoot, Ellen, Pereda, José M. de, Takagi, Junichi, Vidarsson, Gestur   +19 more
core   +1 more source