Results 91 to 100 of about 62,112 (126)

Integrin αIIbβ3 regulation in platelets [PDF]

, 2006
In summary, the studies described in this thesis show that discrete parts of the platelet integrin αIIbβ3 are involved in discrete ligand binding sub processes. A tripeptide sequence in the A3 domain of vWF is involved in preactivation of αIIbβ3, leading
Litjens, P.E.M.H.
core  

Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening

, 2010
The platelet integrin αIIbβ3 is essential for hemostasis and thrombosis through its binding of adhesive plasma proteins. We have determined crystal structures of the αIIbβ3 headpiece in the absence of ligand and after soaking in RUC-1, a novel small ...
Jieqing Zhu, Timothy A. Springer, Ana Negri, Marta Filizola, Jianghai Zhu, Davide Provasi, Barry S. Coller   +6 more
core   +1 more source

Endoplasmic reticulum protein 29 negatively regulates platelet functions and thrombosis in mice

Thrombosis Journal
Background Several members of protein disulfide isomerase (PDI) family with the CXYC active motif such as PDI, ERp57, ERp72, ERp46, ERp5 and TMX1 have important roles in platelet functions and thrombosis.
Xiaofeng Yan, Yishan Lu, Keyu Lv, Miao Jiang, Chao Fang, Yi Wu, Aizhen Yang   +6 more
doaj   +1 more source

Platelet Activation Pathways Controlling Reversible Integrin αIIbβ3 Activation

Background Agonist-induced platelet activation, with the integrin αIIbβ3 conformational change, is required for fibrinogen binding. This is considered reversible under specific conditions, allowing a second phase of platelet aggregation.
Jinmi Zou, de Laat, Bas, Roest, Mark, Bas de Laat, Swieringa, Frauke, De Simone, Ilaria, Philip G. de Groot, Frauke Swieringa, Mark Roest, Zou, Jinmi, de Groot, Philip G, Siyu Sun, Hugo ten Cate, Sun, Siyu, Heemskerk, Johan W M, Ten Cate, Hugo, Ilaria De Simone, Johan W.M. Heemskerk   +17 more
core   +1 more source

Mechanistic Basis for the Binding of RGD- and AGDV-Peptides to the Platelet Integrin αIIbβ3

, 2020
© 2017 American Chemical Society.Binding of soluble fibrinogen to the activated conformation of the integrin αIIbβ3 is required for platelet aggregation and is mediated exclusively by the C-terminal AGDV-containing dodecapeptide (γC-12) sequence of the ...
Weisel J., Klochkov V., Litvinov R., Barsegov V., Kononova O., Bennett J., Blokhin D.   +6 more
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β3 Tyrosine Phosphorylation in αIIbβ3 (Platelet Membrane GP IIb-IIIa) Outside-in Integrin Signaling

, 2001
SummaryThe platelet integrin αIIbβ3 not only binds fibrinogen and von Willebrand factor to mediate platelet aggregation and adhesion, it also serves as a signaling receptor.
K. S. Srinivasa Prasad, David Phillips, Lisa Nannizzi-Alaimo   +2 more
core   +1 more source

Evidence that the Platelet Integrin αIIbβ3 Is Regulated by the Integrin-Linked Kinase, ILK, in a PI3-Kinase Dependent Pathway

, 2002
SummaryPlatelet aggregation is mediated by the integrin αIIbβ3 which is activated by intracellular signals during platelet activation. We have attempted to determine if ILK (“Integrin-Linked Kinase”) is involved in the regulation of αIIbβ3 function.
Jean-Max Pasquet, Malia Noury, Alan Nurden   +2 more
core   +1 more source

WITHDRAWN: "Exogenous carbon monoxide suppresses LPS-induced platelet SNAREs complex assembly and α-granule exocytosis via integrin αIIbβ3-mediated PKCθ/Munc18a pathway"

Oncotarget, 2018
Mingfeng Zhuang, Mingming Song, Dadong Liu, Jiamin Huang, Xiaohan Xu, Weiting Qin, Bingwei Sun   +6 more
openaire   +2 more sources

Extracellular thiol isomerase ERp5 regulates integrin αIIbβ3 activation by inhibition of fibrinogen binding

Platelets
Recent studies have shown that anti-ERp5 antibodies inhibit platelet activation and thrombus formation; Moreover, ERp5-deficient platelets exhibit enhanced platelet reactivity via regulation of endoplasmic reticulum (ER) stress.
Kaifei Sun, Yaqiong Zhang, Aizhen Yang, Yuxin Zhang, Zhenzhen Zhao, Xiaofeng Yan, Yi Lu, Yue Han, Depei Wu, Freda Passam, Jingyu Zhang, Yi Wu   +11 more
doaj   +1 more source

A potential role for α-actinin in inside-out αIIbβ3 signaling

, 2011
Many different biochemical signaling pathways regulate integrin activation through the integrin cytoplasmic tail. Here, we describe a new role for α-actinin in inside-out integrin activation.
Tsuyoshi Kamae, Tsuyoshi Nakazawa, Yoshiaki Tomiyama, Kazunobu Kiyomizu, Yuzuru Kanakura, Hirokazu Kashiwagi, Seiji Tadokoro, Shigenori Honda   +7 more
core   +1 more source