Results 141 to 150 of about 35,988 (205)

Targeting Tumor Stroma: Current Challenges and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang, Haofan Hu, Weifeng Zeng, Lu Qin, Xiaoping Chen, Zhibin Liao, Furong Liu, Zhanguo Zhang   +7 more
wiley   +1 more source

Subclinical myocardial dysfunction in treatment naive papillary thyroid carcinoma patients

Scientific Reports
Papillary thyroid carcinoma (PTC) may contribute to cardiovascular (CV) morbidity through pro-inflammatory signaling and endothelial dysfunction, yet subclinical myocardial effects remain poorly characterized.
Safak Akin, Gokhan Giray Akgul, Mehmet Ali Gulcelik, Murat Celik, Uygar Cagdas Yuksel, Cevdet Erdol, Nese Ersoz Gulcelik   +6 more
doaj   +1 more source

Efferocytosis: Signaling Pathways and New Therapeutic Strategies for Diseases

MedComm, Volume 7, Issue 5, May 2026.
1. Efferocytosis coordinates molecular signaling and metabolic reprogramming to resolve inflammation. 2. Efferocytosis dysfunction underlies four conserved pathological hallmarks across diseases. 3. Therapeutic strategies targeting efferocytosis should be context‐dependent: enhance or inhibit based on disease type. ABSTRACT Efferocytosis—the phagocytic
Lei Wang, Jingjing Ge, Zehua Wang, Yihua Fang, Yongxu Jia, Ruyue Zhang, Yanru Qin   +6 more
wiley   +1 more source

External Stimuli‐Activable Single‐Atom Nanozymes for Bioapplications

Small, Volume 22, Issue 29, 22 May 2026.
Stimuli‐activable single‐atom nanozymes (SANs) are reviewed from materials design to biomedical applications. We explain electronic‐structure tuning principles and synthesis strategies that maximize the responsiveness of metal active sites and supports to light, ultrasound, and magnetic fields.
Hyun Ko, Jungsue Choi, Hyeonjeong Noh, Sohyeon Seo, Heedong Kwon, Seungjune Lee, Hyoyoung Lee   +6 more
wiley   +1 more source

The Critical Role of GALNTs‐Regulated O‐GalNAc Glycosylation in Cancer Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Jiahao Liu, Sihan Wu, Ge Zhang, Jiehan Li, Yuhan Yin, Aman Uiiah, Sanfei Peng, Yang Fu   +7 more
wiley   +1 more source

Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF‑κB and MAPK signalling transduction through integrin αVβ3. [PDF]

Int J Mol Med, 2023
Wan J, Li M, Yuan X, Yu X, Chen A, Shao M, Kang H, Cheng P.   +7 more
europepmc   +1 more source

Integrin-αvβ3 as a Therapeutic Target in Glioblastoma: Back to the Future? [PDF]

Pharmaceutics, 2022
Echavidre W, Picco V, Faraggi M, Montemagno C.   +3 more
europepmc   +1 more source

Structural basis for the differential recognition of integrin αvβ3 by rhodostomin and trimucrin. [PDF]

Commun Biol
Wang YT, Chang YT, Huang CH, Liau CT, Chen CY, Chuang WJ.   +5 more
europepmc   +1 more source

Integrin αvβ3 is a Potential Therapeutic Target in Cholangiocarcinoma. [PDF]

Int J Med Sci
Wulandari FS, Wang CY, Crawford DR, Yang YN, Then CK, Kumar S, Suk FM, Huang LY, Yang YS, Li ZL, Shih YJ, Tu HT, Wang K, Phu HD, Lin CM, Xuan DTM, Solomon DD, Lin HY, Whang-Peng J.   +18 more
europepmc   +1 more source

Integrin αVβ3 Signaling in the Progression of Osteoarthritis Induced by Excessive Mechanical Stress. [PDF]

Inflammation, 2023
Song F, Mao X, Dai J, Shan B, Zhou Z, Kang Y.   +5 more
europepmc   +1 more source