Results 121 to 130 of about 81,327 (201)

Ligand binding promiscuity of αVβ3 integrin is enlarged in response to mechanical force

, 2017
αVβ3 integrin recognizes multiple extracellular matrix proteins, including vitronectin (Vn) and fibronectin (Fn). However, cell experiments are frequently performed on homogenously coated substrates with only one integrin ligand present.
Vasyl V. Mykuliak, Bernhard Wehrle-Haller, Kai Weißenbruch, Sarah Krübel, Martin Bastmeyer, Marta Ripamonti, Lia Heiser, Michael Bachmann, Vesa P. Hytönen, Markus Schäfer, Clemens M. Franz   +10 more
core   +1 more source

Understanding the Potential of Antibody‐Drug Conjugates Functionalized Engineered Exosomes in Hepatocellular Carcinoma Therapy: A Comprehensive Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Exosomes are naturally secreted nanovesicles with high biocompatibility, low immunogenicity, and the ability to traverse biological barriers, making them attractive theragnostic carriers. When engineered to present tumor‐specific antibodies and to deliver antibody‐drug conjugates (ADCs), they may enhance selective targeting of ...
Subham Sarkar, Avinaba Bose, Jenifer Rajak, Arup Kumar Mitra, Ajoy Kumer, Bikram Dhara   +5 more
wiley   +1 more source

Increased renal integrin αvβ3 expression in anti-GBM disease.

, 2013
(a–c) IHC staining of mouse kidney sections with an anti-integrin αvβ3 antibody (1:500 dilution). (a) Normal control kidney; (b) nephritic kidney subjected to anti-GBM disease; (c) Semi-quantitative analysis of integrin αvβ3 expression (N = 6 for each ...
Xin J. Zhou (305431), Shion An (305429), Chandra Mohan (157054), Li Liu (75607), Yong Du (86188), Ralph P. Mason (131100), Li Li (14993)   +6 more
core   +1 more source

Co‐Optimization of Mechanical Performance and Osseointegration of Titanium‐Based Composites via a Novel Microwave‐Driven Boronization Strategy

Rare Metals, Volume 45, Issue 10, October 2026.
ABSTRACT The use of Ti6Al4V alloy in dental implantation is constrained by its high elastic modulus and biological inertness, which lead to delayed osseointegration and a high failure risk. Additionally, its chemical incompatibility with hydroxyapatite (HA) impedes the development of stable bioactive composites.
Shangyong Zuo, Hengrong Xiong, Xiaojie Chen, Yihong Chen, Xiupeng Zhu, Boyu Liu, Zhiwei Peng, Ailiang Chen, Qian Peng   +8 more
wiley   +1 more source

DNA Origami Uptake in Y‐79 Retinoblastoma Cells Driven by Oligolysine Coating

Small Structures, Volume 7, Issue 10, October 2026.
We show that polymeric coating can enable DNA origami nanoparticle internalization into ocular retinoblastoma cells. Not only are the coated nanoparticles well‐tolerable to the cells, but they also remain mobile in the vitreous of a porcine ex vivo model.
Anna Klose, Zahra Gounani, Sergei Raik, Artturi Koivuniemi, Sonja Korhonen, Mika Reinisalo, Tatu Lajunen, Veikko Linko, Timo Laaksonen   +8 more
wiley   +1 more source

Overcoming Photodynamic Therapy Resistance: GSH‐Responsive AIE Photosensitizer‐Hydroxycamptothecin Nanoliposomes for Extrahepatic Cholangiocarcinoma

Advanced Healthcare Materials, Volume 15, Issue 35, 18 September 2026.
A GSH‐responsive AIE nanoplatform (TSH NPs) with RGD‐mediated tumor targeting co‐delivers a photosensitizer (TPA) and HCPT for extrahepatic cholangiocarcinoma. The system synergistically enhances PDT and chemotherapy by suppressing HIF‐1α/VEGF‐driven hypoxic adaptation, effectively overcoming PDT resistance.
Yong Qu, Tao Peng, Yating Zhang, Juanmei Cao, Birong Wang, Chuxing Chai, Zhiyuan Gao, Yiting Xu, Yifan Jin, Yuqing Wang, Zhuoxia Li, Xu Liu, Tianqi Zhao, Yufan Chen, Weimin Lv, Di Lu, Changzheng Huang, Dan Ding, Jinxiang Zhang, Min Li   +19 more
wiley   +1 more source

Cyclic isoDGR peptidomimetics: biological evaluation as integrin antagonists and synthesis of tumor-homing conjugates

, 2016
Integrins are a large family of cell adhesion receptors composed of two non-covalently bound α and β transmembrane glycoproteins and are involved in important physiological and pathological processes.[1] Several integrins, including αVβ3, αVβ5, α5β1, and
D. Arosio, M. Paolillo, L. Pignataro, L. Belvisi, S. Schinelli, C. Gennari, S. Panzeri, U. Piarulli, S. Zanella, S. Angerani, A. Dal Corso   +10 more
core   +2 more sources

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley   +1 more source

Spatial and Temporal Heterogeneity of Macrophage Efferocytosis in Tumors: Emerging Implications for Immunotherapy Biomarkers and Therapeutic Timing

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Resistance to immune checkpoint blockade (ICB) remains a major barrier in cancer therapy, reflecting the fact that tumor immunity is governed not only by cell type abundance but also by spatial organization and temporal dynamics within the tumor microenvironment (TME).
Shanyi Li, Jilei Li, Zhenyu Zhang, Sizhe Wang, Chunzheng Ma   +4 more
wiley   +1 more source