Results 81 to 90 of about 81,327 (201)

Prostate cancer sheds the αvβ3 integrin in vivo through exosomes.

, 2019
The αvβ3 integrin has been shown to promote aggressive phenotypes in many types of cancers, including prostate cancer. We show that GFP-labeled αvβ3 derived from cancer cells circulates in the blood and is detected in distant lesions in NOD scid gamma ...
Goswami, Chirayu P, Peiper, Stephen C, Wang, Kerith, Hawkins, Adam, Kurtoglu, Senem, Krishn, Shiv Ram, Singh, Amrita, Kelly, William K, Friedman, Andrea, Duffy, Alexander N, Sayeed, Aejaz, Thakur, Madhukar L, Iozzo, Renato V, Bowler, Nicholas, Languino, Lucia R, Tripathi, Sushil K, Fedele, Carmine   +16 more
core   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Glycosylated dendrimer nanoamplifiers hijack DNA damage‐immune crosstalk for enhanced dual‐track therapy of orthotopic glioblastoma

BMEMat, EarlyView.
A glycosylated dendrimer nanoamplifier hijacks DNA damage‐immune crosstalk for enhanced radio‐immunotherapy of glioblastoma. The responsive release of demethylcantharidin simultaneously blocks repair‐mediated resistance by inhibiting DNA repair and overcomes adaptive immune resistance.
Cong Song, Binghan Liu, Junjie Liu, Ce Li, Wenqing Man, Xurui Sun, Chang Yuan, Yanjun Wang, Hong Pan, Shuanglian Wang, Zhiming Zheng   +10 more
wiley   +1 more source

Quantitative evaluation of hepatic integrin αvβ3 expression by positron emission tomography imaging using 18F-FPP-RGD2 in rats with non-alcoholic steatohepatitis

EJNMMI Research, 2020
Background Integrin αvβ3, which are expressed by activated hepatic stellate cells in non-alcoholic steatohepatitis (NASH), play an important role in the fibrosis.
Shuichi Hiroyama, Takemi Rokugawa, Miwa Ito, Hitoshi Iimori, Ippei Morita, Hiroki Maeda, Kae Fujisawa, Keiko Matsunaga, Eku Shimosegawa, Kohji Abe   +9 more
doaj   +1 more source

αVβ3 Integrin regulates astrocyte reactivity

, 2017
Indexación: ScopusBackground: Neuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging αVβ3 Integrin and Syndecan-4.
Alvarez, Alvaro, Quest, Andrew F.G., Burgos-Bravo, Francesca, Herrera-Molina, Rodrigo, Rojas, Fabiola, Pérez-Nuñez, Ramón, Rojas-Mancilla, Edgardo, Leyton, Lisette, Lagos-Cabré, Raúl, Schneider, Pascal, Kong, Milene, van Zundert, Brigitte, Herrera-Marschitz, Mario, Cárdenas, Areli   +13 more
core  

Integrating chemo‐mechanical cues in nano‐microscale environments for stem cell regulation

BMEMat, EarlyView.
Nano/microscale control strategies, including nano/microscale materials, ligand spacings, and cell encapsulating gels, cell mechanics, integrin signaling, and biochemical cues to direct stem cell fate, tissue regeneration, and organoid engineering, enabling advanced biomedical applications through mechanoregulation at cell‐material interfaces ...
Rajendra K. Singh, Varsha Sagar, Amal George Kurian, Shreyas Kumar Jain, Hye Sung Kim, Hae‐Won Kim   +5 more
wiley   +1 more source

Activated tumor cell integrin αVβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream. [PDF]

, 2016
Metastasis is the main cause of death in cancer patients, and understanding mechanisms that control tumor cell dissemination may lead to improved therapy. Tumor cell adhesion receptors contribute to cancer spreading. We noted earlier that tumor cells can
Tschan, Mario, Torbett, Bruce E, Weber, Martin R, Krueger, Joseph S, Quigley, James P, Marchese, Patrizia, Weber, MR, Ruggeri, Zaverio M, Felding, BH, Zuka, M, Zuka, Masahiko, Zijlstra, A, Zijlstra, Andries, Eliceiri, BP, Staflin, Karin, Lorger, Mihaela, Staflin, K, Tschan, M, Krueger, JS, Rugerri, ZM, Lorger, M, Felding, Brunhilde H, Quigley, JP, Marchese, P, Eliceiri, Brian P, Torbett, BE   +25 more
core   +3 more sources

Extracellularly Activatable Conjugates of RGD Peptidomimetics and Cryptophycin for αVβ3‐Targeted Cancer Therapy

Chemistry – A European Journal, EarlyView.
Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt, Henriette Hartung, Jonah Kammer, Norbert Sewald   +3 more
wiley   +1 more source

Synthesis and biological evaluation of RGD and isoDGR peptidomimetic-α-amanitin conjugates for tumor-targeting

Beilstein Journal of Organic Chemistry, 2018
RGD-α-amanitin and isoDGR-α-amanitin conjugates were synthesized by joining integrin ligands to α-amanitin via various linkers and spacers. The conjugates were evaluated for their ability to inhibit biotinylated vitronectin binding to the purified αVβ3 ...
Lizeth Bodero, Paula López Rivas, Barbara Korsak, Torsten Hechler, Andreas Pahl, Christoph Müller, Daniela Arosio, Luca Pignataro, Cesare Gennari, Umberto Piarulli   +9 more
doaj   +1 more source