Results 91 to 100 of about 234,137 (355)

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

β1 integrin-mediated multicellular resistance in hepatocellular carcinoma through activation of the FAK/Akt pathway

Journal of International Medical Research, 2018
Objective To explore the role and mechanism of β1 integrin in the regulation of multicellular drug resistance in hepatocellular carcinoma (HCC). Methods This in vitro study used a liquid overlay technique to obtain multicellular spheroids of two human ...
Tao Tian, Chun-Li Li, Xiao Fu, Shu-Hong Wang, Jun Lu, Hui Guo, Yu Yao, Ke-Jun Nan, Yu-Juan Yang   +8 more
doaj   +1 more source

Enhancing Therapeutic Efficacy of Oncolytic Herpes Simplex Virus-1 with Integrin β1 Blocking Antibody OS2966

Molecular Cancer Therapeutics, 2019
Integrin β1 receptor, expressed on the surface of tumor cells and macrophages in the tumor microenvironment (TME), has been implicated in both tumor progression and resistance to multiple modalities of therapy.
T. Lee, M. Nair, Yeshavanth Banasavadi-Siddegowda, Yeshavanth Banasavadi-Siddegowda, Joseph Liu, T. Nallanagulagari, T. Nallanagulagari, A. C. Jaime-Ramirez, Jeffrey Yunhua Guo, Jeffrey Yunhua Guo, H. Quadri, Jianying Zhang, K. Bockhorst, M. Aghi, W. S. Carbonell, B. Kaur, J. Yoo   +16 more
semanticscholar   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Integrin β1, Osmosensing, and Chemoresistance in Mouse Ehrlich Carcinoma Cells

Cellular Physiology and Biochemistry, 2015
Background/Aims: Altered expression of the integrin family of cell adhesion receptors has been associated with initiation, progression, and metastasis of solid tumors as well as in the development of chemoresistance.
Belinda Halling Sørensen, Line Jee Hartmann Rasmussen, Bjørn Sindballe Broberg, Thomas Kjær Klausen, Daniel Peter Rafael Sauter, Ian Henry Lambert, Anders Aspberg, Else Kay Hoffmann   +7 more
doaj   +1 more source

The Solute Carrier MFSD1 Decreases the Activation Status of β1 Integrin and Thus Tumor Metastasis

Frontiers in Oncology, 2022
Solute carriers are increasingly recognized as participating in a plethora of pathologies, including cancer. We describe here the involvement of the orphan solute carrier Major Facilitator Superfamily Domain-containing protein 1 (MFSD1) in the regulation
Marko Roblek, Julia Bicher, Merel van Gogh, Attila György, Rita Seeböck, Bozena Szulc, Markus Damme, Mariusz Olczak, Lubor Borsig, Daria E. Siekhaus   +9 more
doaj   +1 more source

Integrin β1 is an essential factor in vasculogenic mimicry of human cancer cells

Cancer Science, 2018
Vasculogenic mimicry (VM) formation by cancer cells is known to play a crucial role in tumor progression, but its detailed mechanism is unclear. In the present study, we focused on integrin β1 (ITGB1) and assessed the role of ITGB1 in VM formation.
R. Kawahara, Y. Niwa, S. Simizu
semanticscholar   +1 more source

Spheroid Cell Aggregation Enhanced by Enzyme‐Free Ultrasound‐Detached Cells

Advanced Biology, EarlyView.
This study demonstrates that ultrasound‐based, enzyme‐free cell detachment accelerates spheroid formation by preserving surface proteins, reducing variability, and enhancing cell aggregation. Comparable engraftment and improved spatial organization in co‐cultured spheroids are observed.
Julien van Delft, Chikahiro Imashiro, Yuta Kurashina, Makoto Hirano, Jun Homma, Shinsuke Mochizuki, Hideharu Shimozawa, Kenjiro Takemura   +7 more
wiley   +1 more source

β1 integrin is essential for blood–brain barrier integrity under stable and vascular remodelling conditions; effects differ with age

Fluids and Barriers of the CNS, 2023
Background Maintaining a tight blood–brain barrier (BBB) is an important prerequisite for the preservation of neurological health, though current evidence suggests it declines with age. While extracellular matrix-integrin interactions play critical roles
Sebok K. Halder, Violaine D. Delorme-Walker, Richard Milner   +2 more
doaj   +1 more source

CHL1 suppresses tumor growth and metastasis in nasopharyngeal carcinoma by repressing PI3K/AKT signaling pathway via interaction with Integrin β1 and Merlin

International Journal on Biological Sciences, 2019
Deletion of Chromosome 3p is one of the most frequently detected genetic alterations in nasopharyngeal carcinoma (NPC). We reported the role of a novel 3p26.3 tumor suppressor gene (TSG) CHL1 in NPC.
Juan Chen, Chen Jiang, L. Fu, Cailei. Zhu, Yan-Qun Xiang, Lingxi Jiang, Qian Chen, Wai Man Liu, Jinna Chen, Li-yi Zhang, Ming Liu, Chao Chen, Hong Tang, Bo Wang, S. Tsao, D. Kwong, X. Guan   +16 more
semanticscholar   +1 more source