Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and b1-integrin activation [PDF]
, 2018 Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Alve, S +17 more
core +1 more source
Bone Research, 2019 Hypertrophic differentiation is not only the terminal process of endochondral ossification in the growth plate but is also an important pathological change in osteoarthritic cartilage.
Chengjie Lian +13 more
semanticscholar +1 more source
Journal of Cellular and Molecular Medicine, 2020 Brain‐derived neurotrophic factor (BDNF) has been reported to participate in fracture healing, whereas the mechanism is still unclear. Since osteoblast migration is important for fracture healing, investigating effects of BDNF on osteoblasts migration ...
Zitao Zhang +4 more
semanticscholar +1 more source
S100A9 promotes prostate cancer cell invasion by activating TLR4/NF-κB/integrin β1/FAK signaling
OncoTargets and Therapy, 2020 Background S100A9, which is expressed in prostate cancer, has been reported in association with prostate cancer progression. However, the role of S100A9 in prostate cancer metastasis is largely unknown. The aim of this study was to investigate the effect
Zhonghua Lv, Wenlin Li, X. Wei
semanticscholar +1 more source
Integrin α3, But Not β1, Regulates Islet Cell Survival and Function via PI3K/Akt Signaling Pathways [PDF]
Endocrinology, 2010 Abstract β1-Integrin is a well-established regulator of β-cell activities; however, the role of its associated α-subunits is relatively unknown. Previously, we have shown that human fetal islet and INS-1 cells highly express α3β1-integrin and that collagens I and IV significantly enhance their survival and function; in addition, blocking
Krishnamurthy, Mansa +5 more
openaire +5 more sources
Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the β1 integrin-RACK1 axis. [PDF]
, 2012 Trop-2 is a transmembrane glycoprotein upregulated in several human carcinomas, including prostate cancer (PrCa). Trop-2 has been suggested to regulate cell-cell adhesion, given its high homology with the other member of the Trop family, Trop-1/EpCAM ...
Alberti, Saverio +3 more
core +2 more sources
RGD-Binding Integrins in Head and Neck Cancers [PDF]
, 2017 YesAlterations in integrin expression and function promote tumour growth, invasion, metastasis and neoangiogenesis. Head and neck cancers are highly vascular tumours with a tendency to metastasise.
Brennan +19 more
core +1 more source
Galectin-3 induces clustering of CD147 and integrin-β1 transmembrane glycoprotein receptors on the RPE cell surface. [PDF]
PLoS ONE, 2013 Proliferative vitreoretinopathy (PVR) is a blinding disease frequently occurring after retinal detachment surgery. Adhesion, migration and matrix remodeling of dedifferentiated retinal pigment epithelial (RPE) cells characterize the onset of the disease.
Claudia S Priglinger +11 more
doaj +1 more source
Activin A increases human trophoblast invasion by upregulating integrin β1 through ALK4
The FASEB Journal, 2020 Activin A promotes human trophoblast invasion during the first trimester of pregnancy and is associated with preeclampsia and pregnancy‐induced hypertension (PE/PIH) in naturally conceived pregnancies.
Shiqin Zhu +6 more
semanticscholar +1 more source
Diet-Induced Muscle Insulin Resistance Is Associated With Extracellular Matrix Remodeling and Interaction With Integrin α2β1 in Mice [PDF]
Diabetes, 2011 OBJECTIVE The hypothesis that high-fat (HF) feeding causes skeletal muscle extracellular matrix (ECM) remodeling in C57BL/6J mice and that this remodeling contributes to diet-induced muscle insulin resistance (IR) through the collagen receptor integrin α2β1 was tested.
Kang, Li +8 more
openaire +4 more sources