Results 51 to 60 of about 234,137 (355)

Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells [PDF]

, 2018
Estrogen receptor α (ERα) is expressed in tissues as diverse as brains and mammary glands. In breast cancer, ERα is a key regulator of tumor progression.
Acconcia, Acconcia, Acerbi, Adlanmerini, Alfredo Cáceres, Ambrose, Andrés M. Toscani, Arjonen, Arnal, Axelrod, Axelrod, Bacia, Bae, Barabas, Bates, Bermudez-Hernandez, Bonifacino, Bradford, Cancer Genome Atlas Network, Caswell, Cerami, Chaumet, Chung, Ciriello, Ciriello, Correia, Cosker, Cosker, Couse, Cox, Dante R. Chialvo, De Franceschi, Debnath, Degasperi, Delcroix, Dozynkiewicz, Dunn, Eirew, Federico Coluccio Leskow, Fernando D. Stefani, Gao, Gao, Ghajar, Gillespie, Gould, Graham, Grant, Han, Han, Hartley, He, Heery, Helleman, Hernández, Hines, Honerkamp-Smith, Ianina L. Violi, Jeselsohn, Johnson, Jonathon N. Lakins, Kate Thi, Kisler, La Rosa, Letoha, Levin, Li, Long, Lu, Lu, Luciano A. Masullo, Luzio, Mak, Marina Simian, Marino, Matthew G. Rubashkin, Mayor, Mayor, Małecki, McDonough, Mina J. Bissell, Moreno-Layseca, Nam, Nardone, Nicovich, Ovesný, Pedram, Pereira, Pietras, Pontiggia, Razandi, Reid, Rocío G. Sampayo, Rust, Savkur, Schindelin, Schlegel, Skliris, Solowska, Su, Sung, Takahashi, Tiwari, Totta, Totta, Upla, Valerie M. Weaver, van de Linde, Vanlandingham, Wang, Waxmonsky, William C. Hines, Yao   +111 more
core   +2 more sources

Osteocyte β1 integrin loss causes low bone mass and impairs bone mechanotransduction in mice

Journal of Orthopaedic Translation, 2022
Background: The key focal adhesion protein β1 integrin plays an essential role in early skeletal development. However, roles of β1 integrin expression in osteocytes during the regulation of bone homeostasis and mechanotransduction are incompletely ...
Lei Qin, Tailin He, Dazhi Yang, Yishu Wang, Zhenjian Li, Qinnan Yan, Peijun Zhang, Zecai Chen, Sixiong Lin, Huanqing Gao, Qing Yao, Zhen Xu, Bin Tang, Weihong Yi, Guozhi Xiao   +14 more
doaj  

Critical role of β1 integrin in postnatal beta-cell function and expansion

Oncotarget, 2017
β1 integrin is essential for pancreatic beta-cell development and maintenance in rodents and humans. However, the effects of a temporal beta-cell specific β1 integrin knockout on adult islet function are unknown. We utilized a mouse insulin 1 promoter driven tamoxifen-inducible Cre-recombinase β1 integrin knockout mouse model (MIPβ1KO) to investigate ...
Peart, Jason, Li, Jinming, Lee, Hojun, Riopel, Matthew, Feng, Zhi Chao, Wang, Rennian   +5 more
openaire   +6 more sources

Integrin β1 Gene Therapy Enhances in Vitro Creation of Tissue-Engineered Cartilage Under Periodic Mechanical Stress

Cellular Physiology and Biochemistry, 2015
Background/Aims: Periodic mechanical stress activates integrin β1-initiated signal pathways to promote chondrocyte proliferation and matrix synthesis. Integrin β1 overexpression has been demonstrated to play important roles in improving the activities ...
Wenwei Liang, Chunhui Zhu, Feng Liu, Weiding Cui, Qing Wang, Zhefeng Chen, Qijia Zhou, Shun Xu, Chenjun Zhai, Weimin Fan   +9 more
doaj   +1 more source

Stability of the tumor suppressor merlin depends on its ability to bind paxillin LD3 and associate with β1 integrin and actin at the plasma membrane [PDF]

Biology Open, 2012
Summary The NF2 gene encodes a tumor suppressor protein known as merlin or schwannomin whose loss of function causes Neurofibromatosis Type 2 (NF2). NF2 is characterized by the development of benign tumors, predominantly schwannomas, in the peripheral nervous system.
Stephen Lambert, Sandra Geden, Maria Elisa Manetti, Nicklaus A. Sparrow, Marga Bott, Cristina Fernandez-Valle   +5 more
openaire   +5 more sources

Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc. [PDF]

, 2013
The extracellular matrix (ECM) of the human intervertebral disc is rich in molecules that interact with cells through integrin-mediated attachments. Porcine nucleus pulposus (NP) cells have been shown to interact with laminin (LM) isoforms LM-111 and LM ...
Bridgen, DT, Brown, CR, Chen, J, Gilchrist, CL, Isaacs, RE, Richardson, WJ, Setton, LA, Yang, KL   +7 more
core   +1 more source

Analysis of the expression and prognostic value of MT1-MMP, β1-integrin and YAP1 in glioma

Open Medicine, 2022
Increased expression of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14) is associated with the development of many cancers. MT1-MMP may promote the entry of yes-associated protein1 (YAP1) into the nucleus by regulating the regulation of β1 ...
Zhai Yangyang, Sang Wei, Su Liping, Shen Yusheng, Hu Yanran, Zhang Wei   +5 more
doaj   +1 more source

β-Adrenergic Receptor-Stimulated Cardiac Myocyte Apoptosis: Role of β1 Integrins [PDF]

Journal of Signal Transduction, 2011
Increased sympathetic nerve activity to the myocardium is a central feature in patients with heart failure. Accumulation of catecholamines plays an important role in the pathogenesis of heart disease. Acting via β-adrenergic receptors (β-AR), catecholamines (norepinephrine and isoproterenol) increase cardiac myocyte apoptosis in vitro and in vivo ...
Amin, Parthiv, Singh, Mahipal, Singh, Krishna   +2 more
openaire   +4 more sources

Regulation of opticin on bioactivity of retinal vascular endothelial cells cultured in collagen [PDF]

International Journal of Ophthalmology, 2020
AIM: To investigate the effects of collagen and opticin on the bioactivity of human retinal vascular endothelial cells (hRVECs), and explore its regulations by integrins and RhoA/ROCK1 signal pathway.
Yue Xing, Xue-Ke Li, Si-Duo Lu, Jin Ma
doaj   +1 more source

SPP1 promotes ovarian cancer progression via Integrin β1/FAK/AKT signaling pathway

OncoTargets and Therapy, 2018
Objectives Ovarian cancer is one of the most lethal malignant tumors in women. Secreted phosphoprotein 1 (SPP1) plays an important role in some cancer types.
B. Zeng, Min Zhou, Huan Wu, Z. Xiong
semanticscholar   +1 more source