Results 71 to 80 of about 234,137 (355)

Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrin β1/FAK/ERK Signaling

Scientific Reports, 2019
Increased Crabp2 levels have been found in various types of cancer, and are associated with poor patients’ survival. Although Crabp2 is found to be overexpressed in lung cancer, its role in metastasis of lung cancer is unclear.
Jun-I. Wu, Yi-Pei Lin, Chien-Wei Tseng, Hui-Jane Chen, Lu‐Hai Wang   +4 more
semanticscholar   +1 more source

Additional file 1: of The small GTPase Rab5c is a key regulator of trafficking of the CD93/Multimerin-2/β1 integrin complex in endothelial cell adhesion and migration

, 2019
Figure S1. Small vesicles containing CD93 colocalize with caveolin-1 in early spreading ECs. Figure S2. Disruption of the actin cytoskeleton impairs CD93 intracellular trafficking. Figure S3. Microtubule cytoskeleton disruption has no effects on CD93 intracellular trafficking. Figure S4.
Barbera, Stefano, Nardi, Federica, Elia, Ines, Realini, Giulia, Lugano, Roberta, Santucci, Annalisa, Tosi, Gian, Dimberg, Anna, Galvagni, Federico, Orlandini, Maurizio   +9 more
openaire   +1 more source

α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. [PDF]

, 2017
Tumors are fibrotic and characterized by abundant, remodeled, and cross-linked collagen that stiffens the extracellular matrix stroma. The stiffened collagenous stroma fosters malignant transformation of the tissue by increasing tumor cell tension to ...
Cassereau, L, García, AJ, Gooch, KJ, Hannachi, E-I, Miroshnikova, YA, Mouw, JK, Ou, G, Pickup, M, Rozenberg, GI, Sarang-Sieminski, AL, Templeman, KL, Weaver, VM   +11 more
core   +2 more sources

Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24, -2 protein secretion

Journal of Experimental & Clinical Cancer Research, 2018
Background Increasing evidence reveals a significant correlation between gamma-synuclein (SNCG) level and tumor invasion and metastasis in various human cancers. Our previous investigation showed that SNCG could secrete into extracellular environment and
Caiyun Liu, Like Qu, Chuanke Zhao, Chengchao Shou   +3 more
doaj   +1 more source

N‐glycosylation by N‐acetylglucosaminyltransferase V enhances the interaction of CD147/basigin with integrin β1 and promotes HCC metastasis

Journal of Pathology, 2018
While the importance of protein N‐glycosylation in cancer cell migration is well appreciated, the precise mechanisms by which N‐acetylglucosaminyltransferase V (GnT‐V) regulates cancer processes remain largely unknown.
J. Cui, Wan Huang, Bo Wu, Jin Jin, Lin Jing, Wen-Pu Shi, Zhen-yu Liu, Lin Yuan, D. Luo, Ling Li, Zhi-Nan Chen, Jian-Li Jiang   +11 more
semanticscholar   +1 more source

Dibutyltin(IV) and Tributyltin(IV) Derivatives of meso-Tetra(4-sulfonatophenyl)porphine Inhibit the Growth and the Migration of Human Melanoma Cells [PDF]

, 2019
Melanoma is the most aggressive and deadly form of skin cancer, which is largely due to its propensity to metastasize. Therefore, with the aim to inhibit the growth and the metastatic dissemination of melanoma cells and to provide a novel treatment ...
Caterina Di Sano, Claudia Pellerito, Fabiana Di Leo, Francesca Costantini, Giovanna Barbieri, Tiziana Fiore   +5 more
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Effects of transforming growth factor β on β1 integrin expression and localization during myogenesis in chicken [PDF]

, 2006
Myoblast-extracellular environment interactions are mediated by the integrin family of cell adhesion receptors. Integrins have been shown to play a pivotal role in skeletal muscle development.
Li, Xuehui
core  

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. [PDF]

, 2003
A considerable body of research indicates that mammary gland branching morphogenesis is dependent, in part, on the extracellular matrix (ECM), ECM-receptors, such as integrins and other ECM receptors, and ECM-degrading enzymes, including matrix ...
A Amour, A Garcia-Gasca, A Lochter, A Lochter, AC Andres, AJ D'Ardenne, AM Belkin, AR Nelson, B Lelongt, BL Hogan, BM Gumbiner, BS Wiseman, C Brisken, C Brisken, CJ Sympson, CS Atwood, CW Daniel, CW Daniel, D Alford, D Alford, DG Stupack, ED Hay, EW Thompson, F Berdichevsky, F Kheradmand, FE Jones, G Bani, G Giannelli, G Shyamala, GB Silberstein, GB Silberstein, GB Silberstein, GB Silberstein, GL Ganser, GW Robinson, GW Robinson, GW Robinson, H Birkedal-Hansen, H Joseph, HJ Hathaway, HY Ha, J Chen, J Lilla, J Muschler, J Russo, J Schlondorff, J Yant, JE Fata, JE Fata, JE Fata, JE Ferguson, JF Wiesen, JJ Wysolmerski, JJ Wysolmerski, JM Bradbury, JM Whitelock, JM Williams, JP Irigoyen, JP Lydon, JP Witty, JT Emerman, K Elenius, K Hotary, K Ito, K Morita, K Wolf, L Hennighausen, LA Rudolph-Owen, LA Rudolph-Owen, LJ van't Veer, LR Lund, M Affolter, M Durbeej, M Egeblad, M Rytomaa, M Simian, MA Arnaout, MD Infeld, MD Sternlicht, MF Horster, MH Barcellos-Hoff, MJ van de Vijver, MM Zutter, MM Zutter, MP Osborne, MR Crowley, MR Warner, MS Wicha, N Koshikawa, N Quarto, NJ Kenney, NK Wessells, OW Petersen, P Bashkin, PR Warfield, PY Desprez, R Lagace, RH Wetzels, RS Talhouk, S Coleman, S Mukherjee, S Selvarajan, S Sinha, S Stahl, SD Banerjee, SD Robinson, SE Baker, SH Barsky, SL Bullock, SM Ellerbroek, T Darribere, T Gudjonsson, T Hayakawa, T Hayakawa, T Hayakawa, TC Klinowska, TC Klinowska, TC Klinowska, TH Vu, TN Seagroves, U Felbor, V Gouon-Evans, V Noe, VM Weaver, W Ruan, W Wang, W Xie, WF Vogel, WF Vogel, WH Yu, WP Bocchinfuso, Y Fukuda, Y Fukuda, Y Hirai, Y Hirai, Y Kadono, Y Nakanishi, YS Kanwar, Z Werb, Z Zhu   +139 more
core   +2 more sources