Results 81 to 90 of about 86,429 (265)

Interfacial Bioengineering of Dynamic Networks Hybrid Hydrogel for Programmed Intervention in Oral Precancerous Epithelial States

Advanced Healthcare Materials, EarlyView.
This study develops a dual‐bioinspired hydrogel, MSA@PGel (macrophage membrane‐coated and salvianolic acid B/5‐aminolevulinic acid co‐loaded liposomes embedded in a polydopamine‐based gel), that integrates macrophage membrane‐mediated active targeting and mussel‐inspired wet adhesion for programmed intervention in oral precancerous lesions.
Xiaoxian Zhao, Ao Zheng, Zhengyan Zhao, Qilin Li, Tianhao Wan, Tanjun Deng, Ying Zhang, Lingyan Cao, Lan Wu   +8 more
wiley   +1 more source

Tensin links energy metabolism to extracellular matrix assembly. [PDF]

, 2017
The regulation of integrin function is key to fundamental cellular processes, including cell migration and extracellular matrix (ECM) assembly. In this issue, Georgiadou et al. (2017. J. Cell Biol.
Calderwood, Emmanuel Dornier, Hardie, Hardie, Horton, Jim C. Norman, McCleverty, Muranen, Pankov, Rainero, Rantala, Rowe, Schiller, Singh, Van Obberghen-Schilling, Yamada   +15 more
core   +3 more sources

Nano‐Engineered Titanium Implants Loaded With Gingival Fibroblasts‐Derived Microvesicles Enhance Early Osseointegration And Soft Tissue Attachment In Vivo

Advanced Healthcare Materials, EarlyView.
Our study showed that human primary gingival fibroblast–derived microvesicles on nano‐engineered titanium implants promote early osseointegration and soft‐tissue attachment in vivo. ABSTRACT Titanium dental implants require both reliable osseointegration and peri‐implant soft tissue seal formation to ensure long‐term success. While osseointegration has
Pingping Han, Chun Liu, Anjana Jayasree, Kamil Sokolowski, Andrew Liaw, Dingbin Liu, Carlos Salomon, Karan Gulati, Ryan SB Lee, Baoxin Huang, Sašo Ivanovski   +10 more
wiley   +1 more source

PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling

Molecular Cancer, 2009
Background Phosphatase of regenerating liver-3 (PRL-3) plays a causative role in tumor metastasis, but the underlying mechanisms are not well understood. In our previous study, we observed that PRL-3 could decrease tyrosine phosphorylation of integrin β1
Wu Jian, Jiang Beihai, Lian Shenyi, Meng Lin, Qu Like, Li Weijun, Xing Xiaofang, Peng Lirong, Shou Chengchao   +8 more
doaj   +1 more source

Ligand-induced epitope masking. Dissociation of integrin α5β1-fibronectin complexes only by monoclonal antibodies with an allosteric mode of action. [PDF]

, 2016
We previously demonstrated that Arg-Gly-Asp (RGD)-containing ligand-mimetic inhibitors of integrins are unable to dissociate pre-formed integrin-fibronectin complexes (IFCs).
Aota, Askari, Askari, Barton, Beglova, Blandin, Burrows, Byron, Campanero, Campanero, Cherry, Cho, Clark, Coe, Collins, Copié, Crump, Dickreuter, Giordano, Goodman, Heidenreich, Hersey, Humphries, Humphries, Hynes, Irie, Kamata, Kasirer-Friede, Kimura, Lee, Luo, Mahalingam, Mason, Mateo, Mould, Mould, Mould, Mould, Mould, Mould, Mould, Mould, Mould, Mould, Muñoz, Müller, Nagae, Ni, Nishimichi, O'Boyle, Orlando, Park, Parsons, Peerschke, Pike, Reardon, Rice, Shen, Takada, Takagi, Van Agthoven, Wilkins, Xia, Xiao, Xiong, Xiong, Yu, Yu, Zhang, Zhang, Zhu   +70 more
core   +1 more source

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

Advanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello, Fabio Variola, Antonio Nanci   +2 more
wiley   +1 more source

Sculpting the Future of Bone: The Evolution of Absorbable Materials in Orthopedics

Advanced Materials, EarlyView.
This review summarizes the current status of polymeric, ceramic, and metallic absorbable materials in orthopedic applications, and highlights several innovative strategies designed to enhance mechanical performance, control degradation, and promote bioactivity. We also discuss the progress and translational potential of absorbable materials in treating
Zhao Wang, Zehui Lv, Xuejie Cai, Yingjie Wang, Bo Peng, Haojing Xu, Hualuo Pang, Xingdong Yang, Jiawei Xu, Yixin Bian, Bin Feng, Peng Wen, Yufeng Zheng, Xisheng Weng   +13 more
wiley   +1 more source

Beta 1 integrin predicts survival in breast cancer: a clinicopathological and immunohistochemical study

Diagnostic Pathology, 2012
Background The main focus of several studies concerned with cancer progression and metastasis is to analyze the mechanisms that allow cancer cells to interact and quickly adapt with their environment.
dos Santos Petra, Zanetti Juliana S, Ribeiro-Silva Alfredo, Beltrão Eduardo IC   +3 more
doaj   +1 more source

Nanoscale imaging of the adhesion core including integrin β1 on intact living cells using scanning electron-assisted dielectric-impedance microscopy. [PDF]

PLoS ONE, 2018
The integrins are a superfamily of transmembrane proteins composed of α and β subunit dimers involved in cell-cell and cell-extracellular matrix interactions. The largest integrin subgroup is integrin β1, which contributes to several malignant phenotypes.
Tomoko Okada, Toshihiko Ogura
doaj   +1 more source

Induction of endothelial cell proliferation by recombinant and microparticle-tissue factor involves β1-integrin and extracellular signal regulated kinase activation [PDF]

, 2010
Objective: Increased levels of circulating tissue factor (TF) in the form of microparticles increase the risk of thrombosis. However, any direct influence of microparticle-associated TF on vascular endothelial cell proliferation is not known.
Collier, Mary E. W., Ettelaie, Camille
core   +1 more source