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The Activation and Regulation of β2 Integrins in Phagocytes and Phagocytosis
Frontiers in Immunology, 2021 Phagocytes, which include neutrophils, monocytes, macrophages, and dendritic cells, protect the body by removing foreign particles, bacteria, and dead or dying cells.
Hao Sun, Liang Hu, Zhichao Fan
exaly +3 more sources
Active elastic dimers: Cells moving on rigid tracks [PDF]
, 2014 Experiments suggest that the migration of some cells in the three-dimensional extra cellular matrix bears strong resemblance to one-dimensional cell migration. Motivated by this observation, we construct and study a minimal one-dimensional model cell made of two beads and an active spring moving along a rigid track.
Das, Moumita +2 more
arxiv +4 more sources
β1 Integrins as Therapeutic Targets to Disrupt Hallmarks of Cancer
Frontiers in Pharmacology, 2015 Integrins belong to a large family of αβ heterodimeric transmembrane proteins first recognized as adhesion molecules that bind to dedicated elements of the extracellular matrix and also to other surrounding cells.
Maxime Lehmann +2 more
exaly +3 more sources
β2 Integrins As Regulators of Dendritic Cell, Monocyte, and Macrophage Function
Frontiers in Immunology, 2017 Emerging evidence suggests that the β2 integrin family of adhesion molecules have an important role in suppressing immune activation and inflammation.
Leonie Schittenhelm +6 more
exaly +3 more sources
Above the Matrix: Functional Roles for Apically Localized Integrins
Frontiers in Cell and Developmental Biology, 2021 Integrins are transmembrane proteins that are most typically thought of as integrating adhesion to the extracellular matrix with intracellular signaling and cell regulation.
Raven J. Peterson +2 more
doaj +1 more source
Integrins in human hepatocellular carcinoma tumorigenesis and therapy
Chinese Medical Journal, 2023 . Integrins are a family of transmembrane receptors that connect the extracellular matrix and actin skeleton, which mediate cell adhesion, migration, signal transduction, and gene transcription.
Qiong Gao +3 more
doaj +1 more source
Integrins in the Immunity of Insects: A Review
Frontiers in Immunology, 2022 Integrins are a large group of cell-surface proteins that are classified as transmembrane proteins. Integrins are classified into different types based on sequence variations, leading to structural and functional diversity.
Saima Kausar +8 more
doaj +1 more source
The relative importance of platelet integrins in hemostasis, thrombosis and beyond
Haematologica, 2023 Integrins are heterodimeric transmembrane receptors composed of α and β chains, with an N-terminal extracellular domain forming a globular head corresponding to the ligand binding site.
Emily Janus-Bell, Pierre H. Mangin
doaj +1 more source
αV-Integrins Are Required for Mechanotransduction in MDCK Epithelial Cells [PDF]
, 2013 The properties of epithelial cells within tissues are regulated by their immediate microenvironment, which consists of neighboring cells and the extracellular matrix (ECM).
Engler, Adam J. +9 more
core +11 more sources
Frontiers in Immunology, 2020 Studies on invertebrate immune receptors can provide insights into characteristics specific to innate immune system. Here, eight α and three β integrins are identified from an invertebrate, the Pacific oyster Crassostrea gigas, and their possible immune ...
Zhao Lv +18 more
doaj +1 more source