The Potential Role of Integrin Signaling in Memory and Cognitive Impairment
Biomolecules, 2023 Dementia currently has no cure and, due to the increased prevalence and associated economic and personal burden of this condition, current research efforts for the development of potential therapies have intensified.
Ifechukwude Joachim Biose +4 more
doaj +1 more source
Integrins regulate stemness in solid tumor: an emerging therapeutic target
Journal of Hematology & Oncology, 2021 Integrins are the adhesion molecules and transmembrane receptors that consist of α and β subunits. After binding to extracellular matrix components, integrins trigger intracellular signaling and regulate a wide spectrum of cellular functions, including ...
Jiangling Xiong +7 more
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Roles of Integrins in Gastrointestinal Cancer Metastasis
Frontiers in Molecular Biosciences, 2021 Integrins are a large family of heterodimeric transmembrane receptors which mediate cell adhesion and transmit signals to the cell interior. The mechanistic roles of integrins have long been an enigma in cancer, given its complexity in regulating ...
Sicong Hou +4 more
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Blocking neutrophil integrin activation prevents ischemia-reperfusion injury. [PDF]
, 2015 Neutrophil recruitment, mediated by β2 integrins, combats pyogenic infections but also plays a key role in ischemia-reperfusion injury and other inflammatory disorders.
Ginsberg, Mark H +6 more
core +2 more sources
Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence?
Frontiers in Cellular and Infection Microbiology, 2021 The RGD motif in the Severe Acute Syndrome Coronavirus 2 (SARS-CoV-2) spike protein has been predicted to bind RGD-recognizing integrins. Recent studies have shown that the spike protein does, indeed, interact with αVβ3 and α5β1 integrins, both of which ...
Christopher A. Beaudoin +5 more
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Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications [PDF]
Science Signaling 12 Jan 2021: Vol. 14, Issue 665, eabd0334, 2020 The primary cell surface receptor for SARS-CoV-2 is the angiotensin-converting enzyme 2 (ACE2). Recently it has been noticed that the viral Spike protein has an RGD motif, suggesting that cell surface integrins may be co-receptors. We examined the sequences of ACE2 and integrins with the Eukaryotic Linear Motif resource, ELM, and were presented with ...
arxiv +1 more source
, 2014 Integrin-mediated cell adhesion is important for development, immune responses, hemostasis and wound healing. Integrins also function as signal transducing receptors that can control intracellular pathways that regulate cell survival, proliferation, and ...
Ginsberg, Mark H
core +1 more source
A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins [PDF]
, 2017 Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation.
Cavalcanti-Adam, Elisabetta Ada +12 more
core +2 more sources
A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration. [PDF]
, 2015 The leading edge of migrating cells contains rapidly translocating activated integrins associated with growing actin filaments that form 'sticky fingers' to sense extracellular matrix and guide cell migration.
Ablack, Jailal N +6 more
core +2 more sources
αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin
Nature Communications, 2017 Interaction of fibronectin with αv-class and α5β1 integrins results in formation of cell adhesion complexes, but the initial events (
Mitasha Bharadwaj +7 more
doaj +1 more source